Brain-enriched hyaluronan binding (BEHAB)/brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family member.
about
Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeatsADAMTS-12 associates with and degrades cartilage oligomeric matrix proteinCharacterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1Versican degradation and vascular diseaseThe proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motilityExpression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumoursAggrecanases and cartilage matrix degradationEvidence for proteolytic cleavage of brevican by the ADAMTSs in the dentate gyrus after excitotoxic lesion of the mouse entorhinal cortexPathophysiological Function of ADAMTS Enzymes on Molecular Mechanism of Alzheimer's DiseaseBrevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sitesVersican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4Discovery and characterization of a novel, widely expressed metalloprotease, ADAMTS10, and its proteolytic activationADAMTS7B, the full-length product of the ADAMTS7 gene, is a chondroitin sulfate proteoglycan containing a mucin domainIdentification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domainThe ADAMTS metalloproteinasesExpression and activity of ADAMTS-5 in synovium.Discordant localization of WFA reactivity and brevican/ADAMTS-derived fragment in rodent brainThe C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3.Abnormal post-translational and extracellular processing of brevican in plaque-bearing mice over-expressing APPsw.Interstitial guidance of cancer invasion.Relevance of IGFBP2 proteolysis in glioma and contribution of the extracellular protease ADAMTS1Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation.ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis.Brevican knockdown reduces late-stage glioma tumor aggressiveness.Determinants of versican-V1 proteoglycan processing by the metalloproteinase ADAMTS5Glial tumor invasion: a role for the upregulation and cleavage of BEHAB/brevican.Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells.ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix proteinProprotein convertases in tumor progression and malignancy: novel targets in cancer therapy.Metzincin proteases and their inhibitors: foes or friends in nervous system physiology?Cell-specific and developmental expression of lectican-cleaving proteases in mouse hippocampus and neocortex.Metalloproteinases: their role in arthritis and potential as therapeutic targets.Quantitative proteomic analysis of oligodendrogliomas with and without 1p/19q deletionAdamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor β1 (TGFβ1) signaling.Extracellular proteases as targets for drug developmentADAMTS expression in colorectal cancerThe endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury.Deconstructing the perineuronal net: cellular contributions and molecular composition of the neuronal extracellular matrix.Extracellular proteolysis in structural and functional plasticity of mossy fiber synapses in hippocampusInvolvement of perineuronal and perisynaptic extracellular matrix in Alzheimer's disease neuropathology
P2860
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P2860
Brain-enriched hyaluronan binding (BEHAB)/brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family member.
description
2000 nî lūn-bûn
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2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Brain-enriched hyaluronan bind ...... motifs (ADAMTS) family member.
@ast
Brain-enriched hyaluronan bind ...... motifs (ADAMTS) family member.
@en
type
label
Brain-enriched hyaluronan bind ...... motifs (ADAMTS) family member.
@ast
Brain-enriched hyaluronan bind ...... motifs (ADAMTS) family member.
@en
prefLabel
Brain-enriched hyaluronan bind ...... motifs (ADAMTS) family member.
@ast
Brain-enriched hyaluronan bind ...... motifs (ADAMTS) family member.
@en
P2093
P2860
P356
P1476
Brain-enriched hyaluronan bind ...... motifs (ADAMTS) family member.
@en
P2093
R T Matthews
S Hockfield
P2860
P304
22695-22703
P356
10.1074/JBC.M909764199
P407
P577
2000-07-01T00:00:00Z