Tissue-specific transformation by epidermal growth factor receptor: a single point mutation within the ATP-binding pocket of the erbB product increases its intrinsic kinase activity and activates its sarcomagenic potential.
about
Enhanced signaling and morphological transformation by a membrane-localized derivative of the fibroblast growth factor receptor 3 kinase domainDisease specificity of kinase domains: the src-encoded catalytic domain converts erbB into a sarcoma oncogeneInhibiting signal transduction: recent advances in the development of receptor tyrosine kinase and Ras inhibitors.The structural impact of cancer-associated missense mutations in oncogenes and tumor suppressors(124)I-iodopyridopyrimidinone for PET of Abl kinase-expressing tumors in vivo.A minor tyrosine phosphorylation site located within the CAIN domain plays a critical role in regulating tissue-specific transformation by erbB kinaseConstitutive activation of the RON gene promotes invasive growth but not transformation.Analysis of the role of the Shc and Grb2 proteins in signal transduction by the v-ErbB protein.Modulation of erbB kinase activity and oncogenic potential by single point mutations in the glycine loop of the catalytic domain.The amino-terminal 14 amino acids of v-src can functionally replace the extracellular and transmembrane domains of v-erbB.Dissecting the activating mutations in v-erbB of avian erythroblastosis virus strain R.Selection criteria for c-Met-targeted therapies: emerging evidence for biomarkers.An activating mutation in the ATP binding site of the ABL kinase domain.The v-erbB oncogene confers enhanced cellular susceptibility to reovirus infection.Induction of renal adenocarcinoma by a nonmutated erbB oncogene.Transforming properties and substrate specificities of the protein tyrosine kinase oncogenes ros and src and their recombinants.Protein tyrosine kinase activities of the epidermal growth factor receptor and ErbB proteins: correlation of oncogenic activation with altered kinetics.Characterization of an activated mutant of focal adhesion kinase: 'SuperFAK'
P2860
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P2860
Tissue-specific transformation by epidermal growth factor receptor: a single point mutation within the ATP-binding pocket of the erbB product increases its intrinsic kinase activity and activates its sarcomagenic potential.
description
1990 nî lūn-bûn
@nan
1990 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年学术文章
@wuu
1990年学术文章
@zh-cn
1990年学术文章
@zh-hans
1990年学术文章
@zh-my
1990年学术文章
@zh-sg
1990年學術文章
@yue
name
Tissue-specific transformation ...... es its sarcomagenic potential.
@ast
Tissue-specific transformation ...... es its sarcomagenic potential.
@en
type
label
Tissue-specific transformation ...... es its sarcomagenic potential.
@ast
Tissue-specific transformation ...... es its sarcomagenic potential.
@en
prefLabel
Tissue-specific transformation ...... es its sarcomagenic potential.
@ast
Tissue-specific transformation ...... es its sarcomagenic potential.
@en
P2093
P2860
P356
P1476
Tissue-specific transformation ...... es its sarcomagenic potential.
@en
P2093
P2860
P304
P356
10.1073/PNAS.87.23.9103
P407
P577
1990-12-01T00:00:00Z