Bortezomib sensitizes human esophageal squamous cell carcinoma cells to TRAIL-mediated apoptosis via activation of both extrinsic and intrinsic apoptosis pathways
about
Trailing TRAIL Resistance: Novel Targets for TRAIL Sensitization in Cancer CellsThe ubiquitin-proteasome system: opportunities for therapeutic intervention in solid tumorsThe TRAIL of oncogenes to apoptosis.Advances in Viral Vector-Based TRAIL Gene Therapy for Cancer.Combination of TRAIL with bortezomib shifted apoptotic signaling from DR4 to DR5 death receptor by selective internalization and degradation of DR4.Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy.A selective inhibitor of the immunoproteasome subunit LMP2 induces apoptosis in PC-3 cells and suppresses tumour growth in nude mice.Therapeutic applications of TRAIL receptor agonists in cancer and beyond.Low-dose bortezomib increases the expression of NKG2D and DNAM-1 ligands and enhances induced NK and γδ T cell-mediated lysis in multiple myeloma.Targeting the extrinsic apoptosis signaling pathway for cancer therapy.Potential usage of proteasome inhibitor bortezomib (Velcade, PS-341) in the treatment of metastatic melanoma: basic and clinical aspectsTargeting c-FLICE-like inhibitory protein (CFLAR) in cancer.Development of Proteasome Inhibitors as Therapeutic Drugs.Combination Treatment with Sublethal Ionizing Radiation and the Proteasome Inhibitor, Bortezomib, Enhances Death-Receptor Mediated Apoptosis and Anti-Tumor Immune Attack.Bortezomib sensitises TRAIL-resistant HPV-positive head and neck cancer cells to TRAIL through a caspase-dependent, E6-independent mechanism.Human mesenchymal stem cells with adenovirus-mediated TRAIL gene transduction have antitumor effects on esophageal cancer cell line Eca-109.Cap-dependent mRNA translation and the ubiquitin-proteasome system cooperate to promote ERBB2-dependent esophageal cancer phenotype.Tricin inhibits proliferation of human hepatic stellate cells in vitro by blocking tyrosine phosphorylation of PDGF receptor and its signaling pathways.Histone deacetylase inhibitor-mediated sensitization to TRAIL-induced apoptosis in childhood malignancies is not associated with upregulation of TRAIL receptor expression, but with potentiated caspase-8 activation.Targeted treatments for metastatic esophageal squamous cell cancer
P2860
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P1343
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P2860
Bortezomib sensitizes human esophageal squamous cell carcinoma cells to TRAIL-mediated apoptosis via activation of both extrinsic and intrinsic apoptosis pathways
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Bortezomib sensitizes human es ...... d intrinsic apoptosis pathways
@ast
Bortezomib sensitizes human es ...... d intrinsic apoptosis pathways
@en
type
label
Bortezomib sensitizes human es ...... d intrinsic apoptosis pathways
@ast
Bortezomib sensitizes human es ...... d intrinsic apoptosis pathways
@en
prefLabel
Bortezomib sensitizes human es ...... d intrinsic apoptosis pathways
@ast
Bortezomib sensitizes human es ...... d intrinsic apoptosis pathways
@en
P2093
P2860
P1476
Bortezomib sensitizes human es ...... d intrinsic apoptosis pathways
@en
P2093
Hideaki Yamana
Jingo Kusukawa
Kazuo Shirouzu
Masayoshi Kage
Motoshi Miyagi
Naoko Seki
Teruhiko Fujii
Thomas J Sayers
Yoshito Akagi
P2860
P304
P356
10.1158/1535-7163.MCT-09-0918
P577
2010-06-01T00:00:00Z