Internalization and sequestration of the human prostacyclin receptor. - Wikidata - awgldk - TriplyDB

Internalization and sequestration of the human prostacyclin receptor.

Internalization and sequestration of the human prostacyclin receptor.

http://www.wikidata.org/entity/Q33908973

about

Selexipag in the treatment of pulmonary arterial hypertension: design, development, and therapy Genetic and pharmacological analysis of prostanoid receptor function Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs A Ser/Thr cluster within the C-terminal domain of the rat prostaglandin receptor EP3alpha is essential for agonist-induced phosphorylation, desensitization and internalization Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling.Internalization and recycling of the human prostacyclin receptor is modulated through its isoprenylation-dependent interaction with the delta subunit of cGMP phosphodiesterase 6.Role of prostacyclin in pulmonary hypertension.Non-steroid anti-inflammatory drugs, prostaglandins, and cancer.Biased suppression of TP homodimerization and signaling through disruption of a TM GxxxGxxxL helical interaction motif.Prostacyclin receptor regulation--from transcription to trafficking.Regulation of CB1 cannabinoid receptor internalization by a promiscuous phosphorylation-dependent mechanism.Immature and mature species of the human Prostacyclin Receptor are ubiquitinated and targeted to the 26S proteasomal or lysosomal degradation pathways, respectively.Pharmacokinetic evaluation of continuous intravenous epoprostenol.Selexipag for the treatment of pulmonary arterial hypertension.Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor.Clinical pharmacology, efficacy, and safety of selexipag for the treatment of pulmonary arterial hypertension.Agonist-dependent internalization and trafficking of the human prostacyclin receptor: a direct role for Rab5a GTPase Uncoupling and endocytosis of 5-hydroxytryptamine 4 receptors. Distinct molecular events with different GRK2 requirements.The effect of the farnesyl protein transferase inhibitor SCH66336 on isoprenylation and signalling by the prostacyclin receptor.Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation.Interaction of the human prostacyclin receptor with Rab11: characterization of a novel Rab11 binding domain within alpha-helix 8 that is regulated by palmitoylation G protein-coupled receptor kinase 6 (GRK6) selectively regulates endogenous secretin receptor responsiveness in NG108-15 cells.Mechanism of cicaprost-induced desensitization in rat pulmonary artery smooth muscle cells involves a PKA-mediated inhibition of adenylyl cyclase.Impaired receptor binding and activation associated with a human prostacyclin receptor polymorphism.

P2860

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P2860

Internalization and sequestration of the human prostacyclin receptor.

http://www.wikidata.org/entity/Q33908973

description

2000 nî lūn-bûn

@nan

2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2000年の論文

@ja

2000年論文

@yue

2000年論文

@zh-hant

2000年論文

@zh-hk

2000年論文

@zh-mo

2000年論文

@zh-tw

2000年论文

@wuu

name

Internalization and sequestration of the human prostacyclin receptor.

@ast

Internalization and sequestration of the human prostacyclin receptor.

@en

type

label

Internalization and sequestration of the human prostacyclin receptor.

@ast

Internalization and sequestration of the human prostacyclin receptor.

@en

prefLabel

Internalization and sequestration of the human prostacyclin receptor.

@ast

Internalization and sequestration of the human prostacyclin receptor.

@en

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P1433

Journal of Biological Chemistry

P1476

Internalization and sequestration of the human prostacyclin receptor.

@en

P2093

E M Smyth

http://www.w3.org/2001/XMLSchema#string

G A FitzGerald

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M P Reilly

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S C Austin

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P2860

Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo

Phosphorylation of human m1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 and protein kinase C

Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C

Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension

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32037-32045

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scholarly article

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10.1074/JBC.M003873200

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41

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275

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2000-10-01T00:00:00Z

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10889200

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