Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization.
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The plasminogen activator inhibitor-2 gene is not required for normal murine development or survivalSerpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systemsThe plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategiesDistal hinge of plasminogen activator inhibitor-1 involves its latency transition and specificities toward serine proteasesRemodeling of the vessel wall after copper-induced injury is highly attenuated in mice with a total deficiency of plasminogen activator inhibitor-1Laser-induced noninvasive vascular injury models in mice generate platelet- and coagulation-dependent thrombiMice lacking factor VII develop normally but suffer fatal perinatal bleedingTransient reduction of placental angiogenesis in PAI-1-deficient miceGlobal gene expression profiling in PAI-1 knockout murine heart and kidney: molecular basis of cardiac-selective fibrosisA specific plasminogen activator inhibitor-1 antagonist derived from inactivated urokinase.Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammationGenetic background determines response to hemostasis and thrombosis.Testosterone suppresses protective responses of the liver to blood-stage malaria.The antifibrinolytic drug tranexamic acid reduces liver injury and fibrosis in a mouse model of chronic bile duct injuryVitronectin is not essential for normal mammalian development and fertility.Ovulation efficiency is reduced in mice that lack plasminogen activator gene function: functional redundancy among physiological plasminogen activators.Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture.Hemostasis and alterations of the central nervous systemA slice of PAIKnockout of plasminogen activator inhibitor 1 gene reduces amyloid beta peptide burden in a mouse model of Alzheimer's disease.Plasminogen activator inhibitor-1 and the kidney.Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium.Potent antitumor activity of a urokinase-activated engineered anthrax toxin.Hypoxia-ischemia or excitotoxin-induced tissue plasminogen activator- dependent gelatinase activation in mice neonate brain microvessels.Fibrinolysis and the control of blood coagulation.Components of the plasminogen activation system promote engraftment of porous polyethylene biomaterial via common and distinct effects.Increased expression of plasminogen activator inhibitor-1 in cardiomyocytes contributes to cardiac fibrosis after myocardial infarction.The vitronectin-binding function of PAI-1 exacerbates lung fibrosis in mice.Plasmin overcomes resistance to prostaglandin E2 in fibrotic lung fibroblasts by reorganizing protein kinase A signalingAbrogation of plasminogen activator inhibitor-1-vitronectin interaction ameliorates acute kidney injury in murine endotoxemia.PAI-1-regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy.Accelerated skin wound healing in plasminogen activator inhibitor-1-deficient miceReduction in fibrotic tissue formation in mice genetically deficient in plasminogen activator inhibitor-1.Bevacizumab promotes venous thromboembolism through the induction of PAI-1 in a mouse xenograft model of human lung carcinoma.Inhibitory Monoclonal Antibodies against Mouse Proteases Raised in Gene-Deficient Mice Block Proteolytic Functions in vivo.Dissecting the urokinase activation pathway using urokinase-activated anthrax toxin.Polyoma middle T-induced vascular tumor formation: the role of the plasminogen activator/plasmin system.Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarction.Plasminogen activation: a mediator of vascular smooth muscle cell apoptosis in atherosclerotic plaquesPAI-1 promotes the accumulation of exudate macrophages and worsens pulmonary fibrosis following type II alveolar epithelial cell injury.
P2860
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P2860
Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization.
description
1993 nî lūn-bûn
@nan
1993 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Plasminogen activator inhibito ...... bination and characterization.
@ast
Plasminogen activator inhibito ...... bination and characterization.
@en
type
label
Plasminogen activator inhibito ...... bination and characterization.
@ast
Plasminogen activator inhibito ...... bination and characterization.
@en
prefLabel
Plasminogen activator inhibito ...... bination and characterization.
@ast
Plasminogen activator inhibito ...... bination and characterization.
@en
P2093
P2860
P356
P1476
Plasminogen activator inhibito ...... bination and characterization.
@en
P2093
Carmeliet P
Kieckens L
Mulligan RC
Prendergast G
Schoonjans L
van Nuffelen A
P2860
P304
P356
10.1172/JCI116892
P407
P577
1993-12-01T00:00:00Z