The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma - Wikidata - awgldk - TriplyDB

The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma

The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma

http://www.wikidata.org/entity/Q33911922

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EMT-Inducing Molecular Factors in Gynecological Cancers Klotho: a tumor suppressor and modulator of the Wnt/β-catenin pathway in human hepatocellular carcinoma Beta-catenin accelerates human papilloma virus type-16 mediated cervical carcinogenesis in transgenic mice Klotho: a humeral mediator in CSF and plasma that influences longevity and susceptibility to multiple complex disorders, including depression Klotho sensitizes human lung cancer cell line to cisplatin via PI3k/Akt pathway The anti-aging and tumor suppressor protein Klotho enhances differentiation of a human oligodendrocytic hybrid cell line α-Klotho expression determines nitric oxide synthesis in response to FGF-23 in human aortic endothelial cells A global profile of gene promoter methylation in treatment-naïve urothelial cancer Overexpression of candidate tumor suppressor ECRG4 inhibits glioma proliferation and invasion.Short hairpin RNA screen indicates that Klotho beta/FGF19 protein overcomes stasis in human colonic epithelial cells The anti-aging factor α-klotho during human pregnancy and its expression in pregnancies complicated by small-for-gestational-age neonates and/or preeclampsia.Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility.Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice Up-regulated miR-199a-5p in gastric cancer functions as an oncogene and targets klotho.Klotho is silenced through promoter hypermethylation in gastric cancer.Molecular basis of Klotho: from gene to function in aging Global DNA methylation in old subjects is correlated with frailty.Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation.Klotho gene polymorphisms are related to colorectal cancer susceptibility.Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity.Promoter methylation confers kidney-specific expression of the Klotho gene Inhibition of lung cancer cells growth, motility and induction of apoptosis by Klotho, a novel secreted Wnt antagonist, in a dose-dependent manner Promoter methylation and age-related downregulation of Klotho in rhesus monkey γKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancers Klotho plays a critical role in clear cell renal cell carcinoma progression and clinical outcome Identification of novel small molecules that elevate Klotho expression.Soluble Serum αKlotho Is a Potential Predictive Marker of Disease Progression in Clear Cell Renal Cell Carcinoma Promoter hypermethylation of KLOTHO; an anti-senescence related gene in colorectal cancer patients of Kashmir valley.Rhein reversal of DNA hypermethylation-associated Klotho suppression ameliorates renal fibrosis in mice Epigenetic reactivation of p21CIP1/WAF1 and KLOTHO by a combination of bioactive dietary supplements is partially ERα-dependent in ERα-negative human breast cancer cells.MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro Klotho gene silencing promotes pathology in the mdx mouse model of Duchenne muscular dystrophy.Klotho, an anti-aging gene, acts as a tumor suppressor and inhibitor of IGF-1R signaling in diffuse large B cell lymphoma.Physiological inhibitors of Wnt signaling.Klotho acts as a tumor suppressor in cancers.Significance of the anti-aging protein Klotho.Klotho: a novel biomarker for cancer.Frequent methylation of the KLOTHO gene and overexpression of the FGFR4 receptor in invasive ductal carcinoma of the breast.microRNA miR-10b inhibition reduces cell proliferation and promotes apoptosis in non-small cell lung cancer (NSCLC) cells.Vitamin D, reactive oxygen species and calcium signalling in ageing and disease.

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The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma

http://www.wikidata.org/entity/Q33911922

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Molecular Cancer

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Inchul Yang

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Lisha Yi

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Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Suppression of aging in mice by the hormone Klotho

Epigenetics of cervical cancer. An overview and therapeutic perspectives

The Wnt signaling pathway in development and disease

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection

Augmented Wnt signaling in a mammalian model of accelerated aging

Papillomaviruses and cancer: from basic studies to clinical application

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