Promoter methylation and age-related downregulation of Klotho in rhesus monkey - Wikidata - awgldk - TriplyDB

Promoter methylation and age-related downregulation of Klotho in rhesus monkey

Promoter methylation and age-related downregulation of Klotho in rhesus monkey

http://www.wikidata.org/entity/Q36483066

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The anti-aging and tumor suppressor protein Klotho enhances differentiation of a human oligodendrocytic hybrid cell line The neuroprotective effect of Klotho is mediated via regulation of members of the redox system.Small-molecule Klotho enhancers as novel treatment of neurodegeneration.Age-associated decrease in global DNA methylation in patients with major depression.Knowledge-based compact disease models identify new molecular players contributing to early-stage Alzheimer's disease.Molecular basis of Klotho: from gene to function in aging Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression Promoter methylation confers kidney-specific expression of the Klotho gene The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS.Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthood.Bisulfite oligonucleotide-capture sequencing for targeted base- and strand-specific absolute 5-methylcytosine quantitation.Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk.MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro Guidelines for diagnosis and management of the cobalamin-related remethylation disorders cblC, cblD, cblE, cblF, cblG, cblJ and MTHFR deficiency.Klotho as a potential biomarker and therapy for acute kidney injury.Identification of cleavage sites leading to the shed form of the anti-aging protein klotho Knowledge-Based Compact Disease Models: A Rapid Path from High-Throughput Data to Understanding Causative Mechanisms for a Complex Disease.Vitamin D: a custodian of cell signalling stability in health and disease.Klotho regulates postnatal neurogenesis and protects against age-related spatial memory loss.Vitamin D, reactive oxygen species and calcium signalling in ageing and disease.Potential application of klotho in human chronic kidney disease.αKlotho and Chronic Kidney Disease.Induction of anti-aging gene klotho with a small chemical compound that demethylates CpG islands.Glucose Oxidase Induces Cellular Senescence in Immortal Renal Cells through ILK by Downregulating Klotho Gene Expression.Hypothesis: cell signalling influences age-related risk of colorectal cancer.Vitamin D deficiency accelerates ageing and age-related diseases: a novel hypothesis.Human alternative Klotho mRNA is a nonsense-mediated mRNA decay target inefficiently spliced in renal disease.The Anti-Aging Protein Klotho Enhances Remyelination Following Cuprizone-Induced Demyelination.Protective Effect of Klotho against Ischemic Brain Injury Is Associated with Inhibition of RIG-I/NF-κB Signaling.Analysis of DNA modifications in aging research.Klotho, the Key to Healthy Brain Aging?

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Promoter methylation and age-related downregulation of Klotho in rhesus monkey

http://www.wikidata.org/entity/Q36483066

description

2011 nî lūn-bûn

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2011年の論文

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2011年学术文章

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2011年学术文章

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2011年学术文章

@zh-hans

2011年学术文章

@zh-my

2011年学术文章

@zh-sg

2011年學術文章

@yue

2011年學術文章

@zh

2011年學術文章

@zh-hant

name

Promoter methylation and age-related downregulation of Klotho in rhesus monkey

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Promoter methylation and age-related downregulation of Klotho in rhesus monkey

@en

type

label

Promoter methylation and age-related downregulation of Klotho in rhesus monkey

@ast

Promoter methylation and age-related downregulation of Klotho in rhesus monkey

@en

prefLabel

Promoter methylation and age-related downregulation of Klotho in rhesus monkey

@ast

Promoter methylation and age-related downregulation of Klotho in rhesus monkey

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Promoter methylation and age-related downregulation of Klotho in rhesus monkey

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P2093

Carmela R Abraham

http://www.w3.org/2001/XMLSchema#string

Douglas L Rosene

http://www.w3.org/2001/XMLSchema#string

Gwendalyn D King

http://www.w3.org/2001/XMLSchema#string

P2860

Association of human aging with a functional variant of klotho.

Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Distinct DNA methylation changes highly correlated with chronological age in the human brain

Suppression of aging in mice by the hormone Klotho

Klotho and aging

The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect

Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin

Transcriptional activation of the human Klotho gene by epidermal growth factor in HEK293 cells; role of Egr-1

Augmented Wnt signaling in a mammalian model of accelerated aging

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1405-1419

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scholarly article

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10.1007/S11357-011-9315-4

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6

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34

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2011-09-16T00:00:00Z

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51646954

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21922250

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