Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses. - Wikidata - awgldk - TriplyDB

Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses.

Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses.

http://www.wikidata.org/entity/Q33916487

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Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila Systematic Aβ Analysis in Drosophila Reveals High Toxicity for the 1-42, 3-42 and 11-42 Peptides, and Emphasizes N- and C-Terminal Residues Nondestructive, real-time determination and visualization of cellulose, hemicellulose and lignin by luminescent oligothiophenes.Localization of cholesterol, amyloid and glia in Alzheimer's disease transgenic mouse brain tissue using time-of-flight secondary ion mass spectrometry (ToF-SIMS) and immunofluorescence imaging.Structural typing of systemic amyloidoses by luminescent-conjugated polymer spectroscopy.Real-time optotracing of curli and cellulose in live Salmonella biofilms using luminescent oligothiophenes.Drosophila melanogaster as a model system for studies of islet amyloid polypeptide aggregation.Probing small molecule binding to amyloid fibrils.Synthesis of a library of oligothiophenes and their utilization as fluorescent ligands for spectral assignment of protein aggregates.The structural basis for optimal performance of oligothiophene-based fluorescent amyloid ligands: conformational flexibility is essential for spectral assignment of a diversity of protein aggregates.Lymphotoxin, but not TNF, is required for prion invasion of lymph nodes.Sensitive and rapid assessment of amyloid by oligothiophene fluorescence in subcutaneous fat tissue.Distinct Spacing Between Anionic Groups: An Essential Chemical Determinant for Achieving Thiophene-Based Ligands to Distinguish β-Amyloid or Tau Polymorphic Aggregates Structure-based drug design identifies polythiophenes as antiprion compounds.Observations in APP bitransgenic mice suggest that diffuse and compact plaques form via independent processes in Alzheimer's disease.Insight into amyloid structure using chemical probes.Cell type related differences in staining with pentameric thiophene derivatives.Contact-mediated intracellular delivery of hydrophobic drugs from polymeric nanoparticles Tracking protein aggregate interactions.Pentameric thiophene-based ligands that spectrally discriminate amyloid-β and tau aggregates display distinct solvatochromism and viscosity-induced spectral shifts.The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice.Polythiophenes inhibit prion propagation by stabilizing prion protein (PrP) aggregates.Cellular uptake and intracellular degradation of poly(alkyl cyanoacrylate) nanoparticles.pFTAA: a high affinity oligothiophene probe that detects filamentous tau in vivo and in cultured neurons Prions and lymphoid organs: solved and remaining mysteries.Superresolution imaging of amyloid fibrils with binding-activated probes AβPP processing results in greater toxicity per amount of Aβ1-42 than individually expressed and secreted Aβ1-42 in Drosophila melanogaster.Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model.Amyloid oligomers: spectroscopic characterization of amyloidogenic protein states.Luminescent conjugated poly- and oligo-thiophenes: optical ligands for spectral assignment of a plethora of protein aggregates.Fluorescence bioimaging with conjugated polyelectrolytes.Highly fluorescent semiconducting polymer dots for biology and medicine Pathology and function of nuclear amyloid. Protein homeostasis matters.Synthesis, characterization, and biological affinity of a near-infrared-emitting conjugated oligoelectrolyte.The Luminescent Oligothiophene p-FTAA Converts Toxic Aβ1-42 Species into Nontoxic Amyloid Fibers with Altered Properties.Differential vital staining of normal fibroblasts and melanoma cells by an anionic conjugated polyelectrolyte.Organic bioelectronics in medicine.Quantitative feature extraction reveals the status quo of protein fibrillation in the cell nucleus.(11)C and (18)F Radiolabeling of Tetra- and Pentathiophenes as PET-Ligands for Amyloid Protein Aggregates.Anionic Oligothiophenes Compete for Binding of X-34 but not PIB to Recombinant Aβ Amyloid Fibrils and Alzheimer's Disease Brain-Derived Aβ.

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P2860

Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses.

http://www.wikidata.org/entity/Q33916487

description

2009 nî lūn-bûn

@nan

2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի օգոստոսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

@zh-tw

2009年论文

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name

Novel pentameric thiophene der ...... gates in cerebral amyloidoses.

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Novel pentameric thiophene der ...... gates in cerebral amyloidoses.

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type

label

Novel pentameric thiophene der ...... gates in cerebral amyloidoses.

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Novel pentameric thiophene der ...... gates in cerebral amyloidoses.

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prefLabel

Novel pentameric thiophene der ...... gates in cerebral amyloidoses.

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Novel pentameric thiophene der ...... gates in cerebral amyloidoses.

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ACS Chemical Biology

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Novel pentameric thiophene der ...... gates in cerebral amyloidoses.

@en

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Andreas Aslund

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Christina J Sigurdson

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Dara L Dickstein

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Eirik Glimsdal

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Frank L Heppner

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K Peter R Nilsson

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Mikael Lindgren

http://www.w3.org/2001/XMLSchema#string

Patrick R Hof

http://www.w3.org/2001/XMLSchema#string

Per Hammarström

http://www.w3.org/2001/XMLSchema#string

Peter Konradsson

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P2860

Protein fibrils in nature can enhance amyloid protein A amyloidosis in mice: Cross-seeding as a disease mechanism

Protein misfolding, functional amyloid, and human disease

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

Two-photon laser scanning fluorescence microscopy

A specific amyloid-beta protein assembly in the brain impairs memory

Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis

Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

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673-684

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10.1021/CB900112V

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8

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4

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David M. Holtzman

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2009-08-01T00:00:00Z

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26687629

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19624097

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2886514

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