Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription.
about
A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell deathNovel nuclear shuttle proteins, HDBP1 and HDBP2, bind to neuronal cell-specific cis-regulatory element in the promoter for the human Huntington's disease geneLive-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis.Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review seriesInteraction of Huntington disease protein with transcriptional activator Sp1The coactivator dTAF(II)110/hTAF(II)135 is sufficient to recruit a polymerase complex and activate basal transcription mediated by CREBMultiple Aspects of Gene Dysregulation in Huntington's DiseaseThe Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesisInteraction between neuronal intranuclear inclusions and promyelocytic leukemia protein nuclear and coiled bodies in CAG repeat diseasesAntithetic effects of MBD2a on gene regulationCoordinate regulation of RARgamma2, TBP, and TAFII135 by targeted proteolysis during retinoic acid-induced differentiation of F9 embryonal carcinoma cellsCell biology of spinocerebellar ataxiaMouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Developing treatment for spinal and bulbar muscular atrophyThe promise and perils of HDAC inhibitors in neurodegenerationHuntingtin: alive and well and working in middle managementFunctional analysis of the TFIID-specific yeast TAF4 (yTAF(II)48) reveals an unexpected organization of its histone-fold domainSleep and circadian dysfunction in neurodegenerative disorders: insights from a mouse model of Huntington's diseaseTwo novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signalingFunctional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's diseaseMitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survivalNuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicityTandem amino acid repeats in the green anole (Anolis carolinensis) and other squamates may have a role in increasing genetic variabilityPhosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson diseaseTrinucleotide repeats: a structural perspectiveEffects of aging and sensory loss on glial cells in mouse visual and auditory cortices.Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1.CAG-encoded polyglutamine length polymorphism in the human genomePrions, amyloids, and RNA: Pieces of a puzzle.The carboxy-terminal fragment of alpha(1A) calcium channel preferentially aggregates in the cytoplasm of human spinocerebellar ataxia type 6 Purkinje cells.Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysisNatural selection drives the accumulation of amino acid tandem repeats in human proteins.cAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity in DrosophilaTAF4 inactivation in embryonic fibroblasts activates TGF beta signalling and autocrine growth.Altered transcription in yeast expressing expanded polyglutamine.Histone deacetylase inhibitors reduce polyglutamine toxicityValosin-containing protein (VCP) in novel feedback machinery between abnormal protein accumulation and transcriptional suppressionChromatin-dependent cooperativity between constitutive and inducible activation domains in CREB.Pathology of CAG repeat diseases.Interaction of expanded polyglutamine stretches with nuclear transcription factors leads to aberrant transcriptional regulation in polyglutamine diseases.
P2860
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P2860
Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription.
description
2000 nî lūn-bûn
@nan
2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年學術文章
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name
Expanded polyglutamine stretch ...... CREB-dependent transcription.
@ast
Expanded polyglutamine stretch ...... CREB-dependent transcription.
@en
type
label
Expanded polyglutamine stretch ...... CREB-dependent transcription.
@ast
Expanded polyglutamine stretch ...... CREB-dependent transcription.
@en
prefLabel
Expanded polyglutamine stretch ...... CREB-dependent transcription.
@ast
Expanded polyglutamine stretch ...... CREB-dependent transcription.
@en
P2093
P356
P1433
P1476
Expanded polyglutamine stretch ...... CREB-dependent transcription.
@en
P2093
Davidson I
Ishiguro H
Kanazawa I
P2888
P356
10.1038/79139
P407
P577
2000-09-01T00:00:00Z