Phenylbutyrate therapy for pyruvate dehydrogenase complex deficiency and lactic acidosis. - Wikidata - awgldk - TriplyDB

Phenylbutyrate therapy for pyruvate dehydrogenase complex deficiency and lactic acidosis.

Phenylbutyrate therapy for pyruvate dehydrogenase complex deficiency and lactic acidosis.

http://www.wikidata.org/entity/Q33918023

about

Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?Essential roles of four-carbon backbone chemicals in the control of metabolism Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket Disulfide isomerase-like protein AtPDIL1-2 is a good candidate for trichlorophenol phytodetoxification Pyruvate dehydrogenase kinase as a potential therapeutic target for malignant gliomas.Phenylbutyrate increases pyruvate dehydrogenase complex activity in cells harboring a variety of defects.One Year Experience of Pheburane(®) (Sodium Phenylbutyrate) Treatment in a Patient with Argininosuccinate Lyase Deficiency.Differential inhibition of PDKs by phenylbutyrate and enhancement of pyruvate dehydrogenase complex activity by combination with dichloroacetate Beneficial effect of feeding a ketogenic diet to mothers on brain development in their progeny with a murine model of pyruvate dehydrogenase complex deficiency.E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity The spectrum of pyruvate oxidation defects in the diagnosis of mitochondrial disorders.Treatment options for lactic acidosis and metabolic crisis in children with mitochondrial disease.The pyruvate dehydrogenase complex in cancer: An old metabolic gatekeeper regulated by new pathways and pharmacological agents.Progress toward improved therapies for inborn errors of metabolism.Pyruvate dehydrogenase as a therapeutic target for obesity cardiomyopathy.Small molecules as therapeutic agents for inborn errors of metabolism.Protein misfolding diseases: prospects of pharmacological treatment.Profile of sodium phenylbutyrate granules for the treatment of urea-cycle disorders: patient perspectives.Identification of enzymes involved in oxidation of phenylbutyrate.Increasing Pyruvate Dehydrogenase Flux as a Treatment for Diabetic Cardiomyopathy: A Combined 13C Hyperpolarized Magnetic Resonance and Echocardiography Study.DDA: A Novel Network-Based Scoring Method to Identify Disease-Disease Associations.Evaluation of Metabolic and Synaptic Dysfunction Hypotheses of Alzheimer's Disease (AD): A Meta-Analysis of CSF Markers.Pyruvate dehydrogenase complex and lactate dehydrogenase as targets for therapy of acute liver failure.Pyruvate is a prospective alkalizer to correct hypoxic lactic acidosis.PDK1: a new therapeutic target for glioblastoma?

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Phenylbutyrate therapy for pyruvate dehydrogenase complex deficiency and lactic acidosis.

http://www.wikidata.org/entity/Q33918023

description

2013 nî lūn-bûn

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2013 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի մարտին հրատարակված գիտական հոդված

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2013年の論文

@ja

2013年論文

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2013年論文

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2013年論文

@zh-hk

2013年論文

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2013年論文

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2013年论文

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name

Phenylbutyrate therapy for pyruvate dehydrogenase complex deficiency and lactic acidosis.

@ast

Phenylbutyrate therapy for pyruvate dehydrogenase complex deficiency and lactic acidosis.

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type

label

Phenylbutyrate therapy for pyruvate dehydrogenase complex deficiency and lactic acidosis.

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Phenylbutyrate therapy for pyruvate dehydrogenase complex deficiency and lactic acidosis.

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prefLabel

Phenylbutyrate therapy for pyruvate dehydrogenase complex deficiency and lactic acidosis.

@ast

Phenylbutyrate therapy for pyruvate dehydrogenase complex deficiency and lactic acidosis.

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SCITRANSLMED.3004986

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Science Translational Medicine

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Phenylbutyrate therapy for pyruvate dehydrogenase complex deficiency and lactic acidosis.

@en

P2093

Brendan Lee

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Edoardo Nusco

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Eleonora Lamantea

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Giuseppe Manco

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Maria I Ferrante

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Nicola Brunetti-Pierri

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Paolo Sordino

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Peter W Stacpoole

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Rosa Ferriero

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P2860

Marked differences between two isoforms of human pyruvate dehydrogenase kinase

Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase

Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism

Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops

Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex

Structure of rat BCKD kinase: Nucleotide-induced domain communication in a mitochondrial protein kinase

Structural basis for flip-flop action of thiamin pyrophosphate-dependent enzymes revealed by human pyruvate dehydrogenase

Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation

Tetrameric assembly and conservation in the ATP-binding domain of rat branched-chain alpha-ketoacid dehydrogenase kinase

Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children

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175ra31

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scholarly article

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10.1126/SCITRANSLMED.3004986

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175

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5

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Massimo Zeviani

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2013-03-01T00:00:00Z

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23467562

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4102924

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