Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
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The effect of oxythioquinox exposure on normal human mammary epithelial cell gene expression: a microarray analysis studyGenetic polymorphisms of CYP2A13 and its relationship to nasopharyngeal carcinoma in the Cantonese populationCharacterization of CYP2A13*2, a variant cytochrome P450 allele previously found to be associated with decreased incidences of lung adenocarcinoma in smokersKey Residues Controlling Phenacetin Metabolism by Human Cytochrome P450 2A EnzymesStructural comparison of cytochromes P450 2A6, 2A13, and 2E1 with pilocarpineNicotine and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Binding and Access Channel in Human Cytochrome P450 2A6 and 2A13 EnzymesGenetic vulnerability and susceptibility to substance dependence.Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritantsBioactivation of the nasal toxicant 2,6-dichlorobenzonitrile: an assessment of metabolic activity in human nasal mucosa and identification of indicators of exposure and potential toxicityCurrent understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessmentContributions of human enzymes in carcinogen metabolismSmoking-Related Gene Expression in Laser Capture-Microdissected Human Lung.The LeFE algorithm: embracing the complexity of gene expression in the interpretation of microarray dataInhibition of Carcinogen-Activating Cytochrome P450 Enzymes by Xenobiotic Chemicals in Relation to Antimutagenicity and Anticarcinogenicity.Binding of diverse environmental chemicals with human cytochromes P450 2A13, 2A6, and 1B1 and enzyme inhibition.Technologies in the Whole-Genome Age: MALDI-TOF-Based Genotyping.Mechanisms of differential expression of the CYP2A13 7520C and 7520G alleles in human lung: allelic expression analysis for CYP2A13 heterogeneous nuclear RNA, and evidence for the involvement of multiple cis-regulatory single nucleotide polymorphismGeneration and characterization of a novel CYP2A13--transgenic mouse model.Conversion events in gene clustersBiomonitoring of urinary cotinine concentrations associated with plasma levels of nicotine metabolites after daily cigarette smoking in a male Japanese population.RNA-Seq quantification of the human small airway epithelium transcriptomeMechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation.Potent mutagenicity of 3-methylindole requires pulmonary cytochrome P450-mediated bioactivation: a comparison to the prototype cigarette smoke mutagens B(a)P and NNK.Identification of cytochrome P450 enzymes critical for lung tumorigenesis by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): insights from a novel Cyp2abfgs-null mousep-dimethylaminocinnamaldehyde derivatization for colorimetric detection and HPLC-UV/vis-MS/MS identification of indolesA Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice.Elucidating Organ-Specific Metabolic Toxicity Chemistry from Electrochemiluminescent Enzyme/DNA Arrays and Bioreactor Bead-LC-MS/MS.Suppression of pulmonary CYP2A13 expression by carcinogen-induced lung tumorigenesis in a CYP2A13-humanized mouse model.Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models.Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.Revealing mammalian evolutionary relationships by comparative analysis of gene clustersInhibition and inactivation of cytochrome P450 2A6 and cytochrome P450 2A13 by menthofuran, β-nicotyrine and mentholGeneration and characterization of a CYP2A13/2B6/2F1-transgenic mouse modelEvaluation of inhibition selectivity for human cytochrome P450 2A enzymesSelective expression of CYP2A13 in human pancreatic α-islet cells.CYP2A6- and CYP2A13-catalyzed metabolism of the nicotine Δ5'(1')iminium ionHuman cyt P450 mediated metabolic toxicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) evaluated using electrochemiluminescent arrays.Hypothesis-based weight-of-evidence evaluation and risk assessment for naphthalene carcinogenesis.Expression of cytochrome P450 2A13 in human non-small cell lung cancer and its clinical significance.Novel Transgenic Mouse Model for Studying Human Serum Albumin as a Biomarker of Carcinogenic Exposure
P2860
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P2860
Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
description
2000 nî lūn-bûn
@nan
2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Human cytochrome P450 CYP2A13: ...... ino)-1-(3-pyridyl)-1-butanone.
@ast
Human cytochrome P450 CYP2A13: ...... ino)-1-(3-pyridyl)-1-butanone.
@en
type
label
Human cytochrome P450 CYP2A13: ...... ino)-1-(3-pyridyl)-1-butanone.
@ast
Human cytochrome P450 CYP2A13: ...... ino)-1-(3-pyridyl)-1-butanone.
@en
prefLabel
Human cytochrome P450 CYP2A13: ...... ino)-1-(3-pyridyl)-1-butanone.
@ast
Human cytochrome P450 CYP2A13: ...... ino)-1-(3-pyridyl)-1-butanone.
@en
P2093
P1433
P1476
Human cytochrome P450 CYP2A13: ...... ino)-1-(3-pyridyl)-1-butanone.
@en
P2093
P304
P407
P577
2000-09-01T00:00:00Z