T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes.
about
The mechanism of release of P-TEFb and HEXIM1 from the 7SK snRNP by viral and cellular activators includes a conformational change in 7SKPhosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytesLimited redundancy in genes regulated by Cyclin T2 and Cyclin T1.T-cell receptor signaling enhances transcriptional elongation from latent HIV proviruses by activating P-TEFb through an ERK-dependent pathway.Phosphorylation of HEXIM1 at Tyr271 and Tyr274 Promotes Release of P-TEFb from the 7SK snRNP Complex and Enhances Proviral HIV Gene Expression.Retroviral cyclin enhances cyclin-dependent kinase-8 activity.P-TEFb Kinase Activity Is Essential for Global Transcription, Resumption of Meiosis and Embryonic Genome Activation in Pig.Effects of Cyclin Dependent Kinase 9 inhibition on zebrafish larvaeComparative drug screening in NUT midline carcinoma.Control of HIV latency by epigenetic and non-epigenetic mechanisms.Cyclin-dependent kinases as therapeutic targets for HIV-1 infection.Short communication: SAHA (vorinostat) induces CDK9 Thr-186 (T-loop) phosphorylation in resting CD4+ T cells: implications for reactivation of latent HIV.The bromodomain protein BRD4 regulates splicing during heat shock.Identification of novel CDK9 and Cyclin T1-associated protein complexes (CCAPs) whose siRNA depletion enhances HIV-1 Tat function.Nuclear speckles: molecular organization, biological function and role in disease.Cyclin T1 and CDK9 T-loop phosphorylation are downregulated during establishment of HIV-1 latency in primary resting memory CD4+ T cells.Phosphatase PPM1A negatively regulates P-TEFb function in resting CD4(+) T cells and inhibits HIV-1 gene expression.Cdk9 T-loop phosphorylation is regulated by the calcium signaling pathway.Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation.
P2860
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P2860
T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
T-loop phosphorylated Cdk9 loc ...... K/HEXIM1 regulatory complexes.
@ast
T-loop phosphorylated Cdk9 loc ...... K/HEXIM1 regulatory complexes.
@en
type
label
T-loop phosphorylated Cdk9 loc ...... K/HEXIM1 regulatory complexes.
@ast
T-loop phosphorylated Cdk9 loc ...... K/HEXIM1 regulatory complexes.
@en
prefLabel
T-loop phosphorylated Cdk9 loc ...... K/HEXIM1 regulatory complexes.
@ast
T-loop phosphorylated Cdk9 loc ...... K/HEXIM1 regulatory complexes.
@en
P2860
P356
P1476
T-loop phosphorylated Cdk9 loc ...... SK/HEXIM1 regulatory complexes
@en
P2093
Eugene C Dow
Hongbing Liu
P2860
P356
10.1002/JCP.22096
P577
2010-07-01T00:00:00Z