Forward genetic analysis reveals multiple gating mechanisms of TRPV4
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TRPV1 structures in distinct conformations reveal activation mechanismsFunction and regulation of TRPP2 ion channel revealed by a gain-of-function mutantGain-of-function mutation in TRPV4 identified in patients with osteonecrosis of the femoral headIncreased basal activity is a key determinant in the severity of human skeletal dysplasia caused by TRPV4 mutationsWild-type and brachyolmia-causing mutant TRPV4 channels respond directly to stretch force.The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cellsL596-W733 bond between the start of the S4-S5 linker and the TRP box stabilizes the closed state of TRPV4 channel.The effect of type-2-diabetes-related vascular endothelial dysfunction on skin physiology and activities of daily living.A channelopathy mechanism revealed by direct calmodulin activation of TrpV4.Human skeletal dysplasia caused by a constitutive activated transient receptor potential vanilloid 4 (TRPV4) cation channel mutation.A competing hydrophobic tug on L596 to the membrane core unlatches S4-S5 linker elbow from TRP helix and allows TRPV4 channel to open.Functional and structural studies of TRP channels heterologously expressed in budding yeast.Yeast luminometric and Xenopus oocyte electrophysiological examinations of the molecular mechanosensitivity of TRPV4.The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1.TRPV4 (Transient Receptor Potential Vanilloid 4) Channel-Dependent Negative Feedback Mechanism Regulates Gq Protein-Coupled Receptor-Induced Vasoconstriction.When size matters: transient receptor potential vanilloid 4 channel as a volume-sensor rather than an osmo-sensor.Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase.Investigating Potassium Channels in Budding Yeast: A Genetic Sandbox
P2860
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P2860
Forward genetic analysis reveals multiple gating mechanisms of TRPV4
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2010 nî lūn-bûn
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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
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2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
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Forward genetic analysis reveals multiple gating mechanisms of TRPV4
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Forward genetic analysis reveals multiple gating mechanisms of TRPV4
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type
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Forward genetic analysis reveals multiple gating mechanisms of TRPV4
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Forward genetic analysis reveals multiple gating mechanisms of TRPV4
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Forward genetic analysis reveals multiple gating mechanisms of TRPV4
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Forward genetic analysis reveals multiple gating mechanisms of TRPV4
@en
P2093
P2860
P356
P1476
Forward genetic analysis reveals multiple gating mechanisms of TRPV4
@en
P2093
Ching Kung
Stephen Loukin
Xinliang Zhou
P2860
P304
19884-19890
P356
10.1074/JBC.M110.113936
P407
P50
P577
2010-04-27T00:00:00Z