Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization. - Wikidata - awgldk - TriplyDB

Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization.

Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization.

http://www.wikidata.org/entity/Q33926415

about

SAMHD1 protects cancer cells from various nucleoside-based antimetabolites.Substrates and Inhibitors of SAMHD1.A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase.SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity Two Scaffolds from Two Flips: (α,β)/(β,γ) CH2/NH "Met-Im" Analogues of dTTP Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer.The druggability of intracellular nucleotide-degrading enzymes.The Dynamic Interplay between HIV-1, SAMHD1, and the Innate Antiviral Response.Structural and dynamical correlations in PfHGXPRT oligomers: A molecular dynamics simulation study.SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity.Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism

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P2860

Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization.

http://www.wikidata.org/entity/Q33926415

description

2014 nî lūn-bûn

@nan

2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization.

@ast

Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization.

@en

type

label

Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization.

@ast

Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization.

@en

prefLabel

Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization.

@ast

Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization.

@en

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P1433

Journal of the American Chemical Society

P1476

Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization.

@en

P2093

Anastasia P Kadina

http://www.w3.org/2001/XMLSchema#string

Boris A Kashemirov

http://www.w3.org/2001/XMLSchema#string

Charles E McKenna

http://www.w3.org/2001/XMLSchema#string

Erik C Hansen

http://www.w3.org/2001/XMLSchema#string

James T Stivers

http://www.w3.org/2001/XMLSchema#string

Kyle J Seamon

http://www.w3.org/2001/XMLSchema#string

Namandjé N Bumpus

http://www.w3.org/2001/XMLSchema#string

P2860

Mechanism of allosteric activation of SAMHD1 by dGTP

Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

( R )-β,γ-Fluoromethylene-dGTP-DNA Ternary Complex with DNA Polymerase β

α,β-Difluoromethylene Deoxynucleoside 5′-Triphosphates: A Convenient Synthesis of Useful Probes for DNA Polymerase β Structure and Function

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

Stereospecific Formation of a Ternary Complex of (S)-α,β-Fluoromethylene-dATP with DNA Pol β

GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells.

Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response.

P304

9822-9825

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scholarly article

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10.1021/JA5035717

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28

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136

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24983818

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