Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response.
about
New insights into an X-traordinary viral proteinRegulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implicationsThe enemy within: endogenous retroelements and autoimmune diseaseThe F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512.Tetherin/BST-2: Restriction Factor or Immunomodulator?Identification of cellular proteins interacting with the retroviral restriction factor SAMHD1Type I interferon in the pathogenesis of lupus.Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization.Mouse knockout models for HIV-1 restriction factors.dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages.SAMHD1 prevents autoimmunity by maintaining genome stability.A continuous enzyme-coupled assay for triphosphohydrolase activity of HIV-1 restriction factor SAMHD1Aicardi-Goutières syndrome and the type I interferonopathies.HERV-K(HML-2), a seemingly silent subtenant - but still waters run deep.Substrates and Inhibitors of SAMHD1.SAMHD1 restricts HIV-1 replication and regulates interferon production in mouse myeloid cells.CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain.Cyclin D3-dependent control of the dNTP pool and HIV-1 replication in human macrophagesPhosphorylation of murine SAMHD1 regulates its antiretroviral activityPhosphorylation of mouse SAMHD1 regulates its restriction of human immunodeficiency virus type 1 infection, but not murine leukemia virus infection.Low dNTP levels are necessary but may not be sufficient for lentiviral restriction by SAMHD1.Heterozygous colon cancer-associated mutations of SAMHD1 have functional significanceRibonuclease H2 mutations induce a cGAS/STING-dependent innate immune response.Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1.Type I interferon-mediated monogenic autoinflammation: The type I interferonopathies, a conceptual overviewIFN-ε protects primary macrophages against HIV infectionHost SAMHD1 protein promotes HIV-1 recombination in macrophages.A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages.Interferon-stimulated genes: roles in viral pathogenesis.Advances in understanding the role of type I interferons in systemic lupus erythematosus.Exogenous expression of SAMHD1 inhibits proliferation and induces apoptosis in cutaneous T-cell lymphoma-derived HuT78 cells.Nucleic acid recognition orchestrates the anti-viral response to retroviruses.A Highly Active Isoform of Lentivirus Restriction Factor SAMHD1 in Mouse.Roles of SAMHD1 in antiviral defense, autoimmunity and cancer.SAMHD1 knockout mice: modeling retrovirus restriction in vivo.Role of Innate Genes in HIV Replication.CD81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levels.A SAMHD1 mutation associated with Aicardi-Goutières syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans.Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity.The Deoxynucleoside Triphosphate Triphosphohydrolase Activity of SAMHD1 Protein Contributes to the Mitochondrial DNA Depletion Associated with Genetic Deficiency of Deoxyguanosine Kinase.
P2860
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P2860
Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Mouse SAMHD1 has antiretrovira ...... -intrinsic antiviral response.
@ast
Mouse SAMHD1 has antiretrovira ...... -intrinsic antiviral response.
@en
type
label
Mouse SAMHD1 has antiretrovira ...... -intrinsic antiviral response.
@ast
Mouse SAMHD1 has antiretrovira ...... -intrinsic antiviral response.
@en
prefLabel
Mouse SAMHD1 has antiretrovira ...... -intrinsic antiviral response.
@ast
Mouse SAMHD1 has antiretrovira ...... -intrinsic antiviral response.
@en
P2093
P2860
P50
P1433
P1476
Mouse SAMHD1 has antiretrovira ...... -intrinsic antiviral response.
@en
P2093
Alexander Gerbaulet
Axel Roers
Dimitra Alexopoulou
Katrin Peschke
Laura A Nguyen
Nadja Schubert
Ronald Naumann
Sabine Wittmann
Siegfried Weiss
P2860
P304
P356
10.1016/J.CELREP.2013.07.037
P577
2013-08-22T00:00:00Z