Functionally important conformations of the Met20 loop in dihydrofolate reductase are populated by rapid thermal fluctuations
about
Molecular dynamics simulations of biological membranes and membrane proteins using enhanced conformational sampling algorithmsDiscovering conformational sub-states relevant to protein functionEffects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reactionChemical Ligation and Isotope Labeling to Locate Dynamic Effects during Catalysis by Dihydrofolate ReductaseData-driven approach to decomposing complex enzyme kinetics with surrogate models.Hydrogen tunneling links protein dynamics to enzyme catalysisUpdate 1 of: Tunneling and dynamics in enzymatic hydride transfer.Hexameric helicase deconstructed: interplay of conformational changes and substrate couplingTemperature dependence of protein motions in a thermophilic dihydrofolate reductase and its relationship to catalytic efficiencyEvidence that a 'dynamic knockout' in Escherichia coli dihydrofolate reductase does not affect the chemical step of catalysis.Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactorsMultiple intermediates, diverse conformations, and cooperative conformational changes underlie the catalytic hydride transfer reaction of dihydrofolate reductase.Barrier Crossing in Dihydrofolate Reductasedoes not involve a rate-promoting vibration.Active site hydrophobic residues impact hydrogen tunneling differently in a thermophilic alcohol dehydrogenase at optimal versus nonoptimal temperatures.Perspective: pre-chemistry conformational changes in DNA polymerase mechanismsThe role of large-scale motions in catalysis by dihydrofolate reductase.Linking protein motion to enzyme catalysis.Extension and limits of the network of coupled motions correlated to hydride transfer in dihydrofolate reductase.Effects of isoleucine 135 side chain length on the cofactor donor-acceptor distance within F420H2:NADP+ oxidoreductase: A kinetic analysis.Examinations of the Chemical Step in Enzyme Catalysis.Direct detection of structurally resolved dynamics in a multiconformation receptor-ligand complexThe effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer.Mechanism of the αβ conformational change in F1-ATPase after ATP hydrolysis: free-energy simulations.Structural and Dynamics Perspectives on the Binding of Substrate and Inhibitors in Mycobacterium tuberculosis DHFRMultiscale molecular dynamics simulations of rotary motor proteins.Protein motions and dynamic effects in enzyme catalysis.High-pressure protein crystal structure analysis of Escherichia coli dihydrofolate reductase complexed with folate and NADP
P2860
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P2860
Functionally important conformations of the Met20 loop in dihydrofolate reductase are populated by rapid thermal fluctuations
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Functionally important conform ...... by rapid thermal fluctuations
@ast
Functionally important conform ...... by rapid thermal fluctuations
@en
type
label
Functionally important conform ...... by rapid thermal fluctuations
@ast
Functionally important conform ...... by rapid thermal fluctuations
@en
prefLabel
Functionally important conform ...... by rapid thermal fluctuations
@ast
Functionally important conform ...... by rapid thermal fluctuations
@en
P2860
P356
P1476
Functionally important conform ...... by rapid thermal fluctuations
@en
P2093
Charles L Brooks Iii
Karunesh Arora
P2860
P304
P356
10.1021/JA9000135
P407
P577
2009-04-01T00:00:00Z