An insertional mutant of epidermal growth factor receptor allows dissection of diverse receptor functions
about
Mechanism of kinase activation in the receptor for colony-stimulating factor 1Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptorReplacement of insulin receptor tyrosine residues 1162 and 1163 does not alter the mitogenic effect of the hormone.Ligand-induced stimulation of epidermal growth factor receptor mutants with altered transmembrane regionsTyrosine phosphorylation of the insulin receptor is not required for receptor internalization: studies in 2,4-dinitrophenol-treated cells.Epidermal growth factor receptor defects in leprechaunism. A multiple growth factor-resistant syndromeEpidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity.Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family--oncogenic activation of v-kit involves deletion of extracellular domain and C terminus.Insulin receptor function in fibroblasts from patients with leprechaunism. Differential alterations in binding, autophosphorylation, kinase activity, and receptor-mediated internalization.Epidermal growth factor (EGF) stimulates association and kinase activity of Raf-1 with the EGF receptor.Release of a phorbol ester-induced mitogenic block by mutation at Thr-654 of the epidermal growth factor receptor.Human epidermal growth factor receptor residue covalently cross-linked to epidermal growth factor.Protein kinase C as a tumor suppressor.Epidermal growth factor (EGF) modulation of feline sarcoma virus fms tyrosine kinase activity, internalization, degradation, and transforming potential in an EGF receptor/v-fms chimera.Domain deletion in the extracellular portion of the EGF-receptor reduces ligand binding and impairs cell surface expression.Synthesis of an enzymatically active FLP recombinase in vitro: search for a DNA-binding domainFunctional analysis of the ligand binding site of EGF-receptor utilizing chimeric chicken/human receptor molecules.Biological activities of EGF-receptor mutants with individually altered autophosphorylation sites.Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3Phorbol esters inhibit insulin-induced receptor down-regulation in cultured human lymphocytes: association with diminished insulin receptor autophosphorylation.Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells.Separate endocytic pathways of kinase-defective and -active EGF receptor mutants expressed in same cells.Protein kinase C: perfectly balanced.
P2860
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P2860
An insertional mutant of epidermal growth factor receptor allows dissection of diverse receptor functions
description
1987 nî lūn-bûn
@nan
1987 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1987 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
name
An insertional mutant of epide ...... of diverse receptor functions
@ast
An insertional mutant of epide ...... of diverse receptor functions
@en
type
label
An insertional mutant of epide ...... of diverse receptor functions
@ast
An insertional mutant of epide ...... of diverse receptor functions
@en
prefLabel
An insertional mutant of epide ...... of diverse receptor functions
@ast
An insertional mutant of epide ...... of diverse receptor functions
@en
P2093
P2860
P1433
P1476
An insertional mutant of epide ...... of diverse receptor functions
@en
P2093
P2860
P304
P407
P577
1987-09-01T00:00:00Z