Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models. - Wikidata - awgldk - TriplyDB

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.

http://www.wikidata.org/entity/Q33930825

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Impaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron Degeneration Autophagy and neurodegeneration Cell-based screening: extracting meaning from complex data.A perspective on stem cell modeling of amyotrophic lateral sclerosis TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets.Autophagy in neurodegenerative diseases: from mechanism to therapeutic approach Autophagosome dynamics in neurodegeneration at a glance Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?Downregulation of MicroRNA-193b-3p Promotes Autophagy and Cell Survival by Targeting TSC1/mTOR Signaling in NSC-34 Cells.RNA metabolism in neurodegenerative disease.Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis.Formation and spreading of TDP-43 aggregates in cultured neuronal and glial cells demonstrated by time-lapse imaging.Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms.The biology of proteostasis in aging and disease.Aberrant RNA homeostasis in amyotrophic lateral sclerosis: potential for new therapeutic targets?Intrinsically disordered proteins and their (disordered) proteomes in neurodegenerative disorders Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathology Linking RNA Dysfunction and Neurodegeneration in Amyotrophic Lateral Sclerosis.Valproate Attenuates 25-kDa C-Terminal Fragment of TDP-43-Induced Neuronal Toxicity via Suppressing Endoplasmic Reticulum Stress and Activating Autophagy.Probing disorders of the nervous system using reprogramming approaches.Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1.PABPN1 suppresses TDP-43 toxicity in ALS disease models.Activation of ER Stress and Autophagy Induced by TDP-43 A315T as Pathogenic Mechanism and the Corresponding Histological Changes in Skin as Potential Biomarker for ALS with the Mutation Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain.Altered localization and functionality of TAR DNA Binding Protein 43 (TDP-43) in niemann- pick disease type C In vivo kinetic approach reveals slow SOD1 turnover in the CNS.Distinct C9orf72-Associated Dipeptide Repeat Structures Correlate with Neuronal Toxicity.Compartment-dependent mitochondrial alterations in experimental ALS, the effects of mitophagy and mitochondriogenesis Modulation of p-eIF2α cellular levels and stress granule assembly/disassembly by trehalose.Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance Clinical Trials in a Dish: The Potential of Pluripotent Stem Cells to Develop Therapies for Neurodegenerative Diseases.Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD.Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43.The Proline/Arginine Dipeptide from Hexanucleotide Repeat Expanded C9ORF72 Inhibits the Proteasome Combating neurodegenerative disease with chemical probes and model systems.ER stress and unfolded protein response in amyotrophic lateral sclerosis-a controversial role of protein disulphide isomerase.Toward stem cell-based phenotypic screens for neurodegenerative diseases.Dysfunction of autophagy as the pathological mechanism of motor neuron disease based on a patient-specific disease model.

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P2860

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.

http://www.wikidata.org/entity/Q33930825

description

2014 nî lūn-bûn

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2014 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2014 թվականի հունիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.

@ast

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.

@en

type

label

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.

@ast

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.

@en

prefLabel

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.

@ast

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.

@en

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Nature Chemical Biology

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Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models

@en

P2093

Aaron Daub

http://www.w3.org/2001/XMLSchema#string

Andrey Tsvetkov

http://www.w3.org/2001/XMLSchema#string

Arpana Arjun

http://www.w3.org/2001/XMLSchema#string

Bilada Bilican

http://www.w3.org/2001/XMLSchema#string

Daniel Peisach

http://www.w3.org/2001/XMLSchema#string

Michael Pleiss

http://www.w3.org/2001/XMLSchema#string

Sami J Barmada

http://www.w3.org/2001/XMLSchema#string

Steven Finkbeiner

http://www.w3.org/2001/XMLSchema#string

Xingli Li

http://www.w3.org/2001/XMLSchema#string

P2860

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

mTOR signaling in growth control and disease

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

Mouse models of frontotemporal dementia

Apg7p/Cvt2p is required for the cytoplasm-to-vacuole targeting, macroautophagy, and peroxisome degradation pathways.

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

ALS: a disease of motor neurons and their nonneuronal neighbors

Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy.

Quantitative relationships between huntingtin levels, polyglutamine length, inclusion body formation, and neuronal death provide novel insight into huntington's disease molecular pathogenesis.

P2888

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677-685

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scholarly article

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10.1038/NCHEMBIO.1563

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8

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10

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Siddharthan Chandran

Dale Michael Ando

P577

2014-06-29T00:00:00Z

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263514811

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24974230

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P921

amyotrophic lateral sclerosis

P932

4106236

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