Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome.
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p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loopMutant p53 attenuates the SMAD-dependent transforming growth factor beta1 (TGF-beta1) signaling pathway by repressing the expression of TGF-beta receptor type IIMutant p53 proteins bind DNA in a DNA structure-selective modeThe p53 pathway in breast cancerOncogenic Intra-p53 Family Member Interactions in Human CancersCircadian disruption and breast cancer: an epigenetic link?Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancerThe role of BH3-mimetic drugs in the treatment of pediatric hepatoblastomaLinks between mutant p53 and genomic instabilityClinical utility of anti-p53 auto-antibody: systematic review and focus on colorectal cancerSmall molecule compounds targeting the p53 pathway: are we finally making progress?The Double Role of p53 in Cancer and Autoimmunity and Its Potential as Therapeutic TargetThe role of p53 in cancer drug resistance and targeted chemotherapyEmerging Non-Canonical Functions and Regulation by p53: p53 and StemnessRas inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosisIntegrity of the N-terminal transcription domain of p53 is required for mutant p53 interference with drug-induced apoptosisTime-Dependent Regulation of Apoptosis by AEN and BAX in Response to 2-Aminoanthracene Dietary ConsumptionDual-faced SH3BGRL: oncogenic in mice, tumor suppressive in humansMutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers.PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations.A novel PTEN/mutant p53/c-Myc/Bcl-XL axis mediates context-dependent oncogenic effects of PTEN with implications for cancer prognosis and therapyMuSiC: identifying mutational significance in cancer genomes.Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion.More targets, more pathways and more clues for mutant p53.Models incorporating chromatin modification data identify functionally important p53 binding sitesTP53 status and taxane-platinum versus platinum-based therapy in ovarian cancer patients: a non-randomized retrospective study.Musashi1 modulates cell proliferation genes in the medulloblastoma cell line DaoyMutant p53 gain-of-function in cancer.Clinical outcomes and correlates of TP53 mutations and cancer.Ataxin-3 expression correlates with the clinicopathologic features of gastric cancerAcetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function.Effects of Terminalia arjuna bark extract on apoptosis of human hepatoma cell line HepG2Genetic mutation analysis of human gastric adenocarcinomas using ion torrent sequencing platform.Germline p53 mutations in a cohort with childhood sarcoma: sex differences in cancer riskLimited importance of the dominant-negative effect of TP53 missense mutationsp53 Interacts with RNA polymerase II through its core domain and impairs Pol II processivity in vivo.Nitric oxide-induced genotoxicity, mitochondrial damage, and apoptosis in human lymphoblastoid cells expressing wild-type and mutant p53.Topical delivery of DNA oligonucleotide to induce p53 generation in the skin via thymidine dinucleotide (pTT)-encapsulated liposomal carrier.Synthetic small inhibiting RNAs: efficient tools to inactivate oncogenic mutations and restore p53 pathways.PIN3 duplication may be partially responsible for TP53 haploinsufficiency
P2860
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P2860
Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome.
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2000 nî lūn-bûn
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2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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Oncogenic mutations of the p53 ...... of the guardian of the genome.
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Oncogenic mutations of the p53 ...... of the guardian of the genome.
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Oncogenic mutations of the p53 ...... of the guardian of the genome.
@ast
Oncogenic mutations of the p53 ...... of the guardian of the genome.
@en
prefLabel
Oncogenic mutations of the p53 ...... of the guardian of the genome.
@ast
Oncogenic mutations of the p53 ...... of the guardian of the genome.
@en
P1433
P1476
Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome
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P2093
P304
P407
P577
2000-12-01T00:00:00Z