Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance.
about
Conserved residues of human XPG protein important for nuclease activity and function in nucleotide excision repairInteraction of p53 with the human Rad51 proteinp53 Binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice.Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53Trans-4-hydroxy-2-nonenal inhibits nucleotide excision repair in human cells: a possible mechanism for lipid peroxidation-induced carcinogenesisp53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent mannerEnhancement of DNA repair in human skin cells by thymidine dinucleotides: evidence for a p53-mediated mammalian SOS responseThe novel PIAS-like protein hZimp10 is a transcriptional co-activator of the p53 tumor suppressorGenetic Stabilization by p53 Involves Growth Regulatory and Repair PathwaysArsenic Disruption of DNA Damage Responses-Potential Role in Carcinogenesis and ChemotherapyTranscription Blockage Leads to New Beginningsp53 in the DNA-Damage-Repair ProcessThe ATR-p53 pathway is suppressed in noncycling normal and malignant lymphocytesActivation and activities of the p53 tumour suppressor proteinInteraction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner.Xeroderma pigmentosum complementation group E protein (XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and putative DNA repair properties.Recognition of helical kinks by xeroderma pigmentosum group A protein triggers DNA excision repair.A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumorsUltraviolet radiation-induced p53 responses in the epidermis are differentiation-dependent.Induction of the SOS response increases the efficiency of global nucleotide excision repair of cyclobutane pyrimidine dimers, but not 6-4 photoproducts, in UV-irradiated Escherichia coli.Limited importance of the dominant-negative effect of TP53 missense mutationsTerminally differentiated human neurons repair transcribed genes but display attenuated global DNA repair and modulation of repair gene expression.p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes.Enhanced sensitivity to cisplatin and gemcitabine in Brca1-deficient murine mammary epithelial cells.Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stressThe DNA damage-binding protein XPC is a frequent target for inactivation in squamous cell carcinomasXPA-mediated regulation of global nucleotide excision repair by ATR Is p53-dependent and occurs primarily in S-phase.Discovery and characterization of DNA excision repair pathways: the work of Philip Courtland Hanawaltp53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene.Interaction between the Cockayne syndrome B and p53 proteins: implications for agingDisruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses.Li-Fraumeni syndrome--a molecular and clinical review.Revisiting the rodent repairadox.The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes.Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence.Role of transcription-coupled DNA repair in susceptibility to environmental carcinogenesisThe tumor suppressor p53 can both stimulate and inhibit ultraviolet light-induced apoptosisExpression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repairThe p53 network in lung carcinogenesis.
P2860
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P2860
Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance.
description
1995 nî lūn-bûn
@nan
1995 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Li-Fraumeni syndrome fibroblas ...... ir and enhanced UV resistance.
@ast
Li-Fraumeni syndrome fibroblas ...... ir and enhanced UV resistance.
@en
type
label
Li-Fraumeni syndrome fibroblas ...... ir and enhanced UV resistance.
@ast
Li-Fraumeni syndrome fibroblas ...... ir and enhanced UV resistance.
@en
prefLabel
Li-Fraumeni syndrome fibroblas ...... ir and enhanced UV resistance.
@ast
Li-Fraumeni syndrome fibroblas ...... ir and enhanced UV resistance.
@en
P2860
P356
P1476
Li-Fraumeni syndrome fibroblas ...... ir and enhanced UV resistance.
@en
P2093
P C Hanawalt
P2860
P304
P356
10.1073/PNAS.92.19.8876
P407
P577
1995-09-01T00:00:00Z