The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens. - Wikidata - awgldk - TriplyDB

The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens.

The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens.

http://www.wikidata.org/entity/Q33940781

about

Use and abuse of dendritic cells by Toxoplasma gondii The gut mucosal immune response to Toxoplasma gondii Identification of the microsporidian Encephalitozoon cuniculi as a new target of the IFNγ-inducible IRG resistance system The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18 Modulation of inflammation by autophagy: Consequences for human disease A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteins Strain- and Dose-Dependent Reduction of Toxoplasma gondii Burden in Pigs Is Associated with Interferon-Gamma Production by CD8+ Lymphocytes in a Heterologous Challenge Model.Interferon-γ-dependent control of Anaplasma phagocytophilum by murine neutrophil granulocytes.Interferon-inducible effector mechanisms in cell-autonomous immunity.Toxoplasma gondii clonal strains all inhibit STAT1 transcriptional activity but polymorphic effectors differentially modulate IFNγ induced gene expression and STAT1 phosphorylation Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes.Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii.Border maneuvers: deployment of mucosal immune defenses against Toxoplasma gondii.Palmitoylation of the immunity related GTPase, Irgm1: impact on membrane localization and ability to promote mitochondrial fission IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8+ T cells in experimental cerebral malaria RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection.The possible association between Toxoplasma gondii infection and risk of anxiety and cognitive disorders in BALB/c mice.Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse The Toxoplasma gondii rhoptry protein ROP18 is an Irga6-specific kinase and regulated by the dense granule protein GRA7.Toxoplasma gondii and the blood-brain barrier.Autophagy in inflammation, infection, neurodegeneration and cancer Genomics of apicomplexan parasites.Irgm1 (LRG-47), a regulator of cell-autonomous immunity, does not localize to mycobacterial or listerial phagosomes in IFN-γ-induced mouse cells.Toxoplasma gondii Infection Promotes Neuroinflammation Through Cytokine Networks and Induced Hyperalgesia in BALB/c Mice.Toxoplasma gondii Infection Potentiates Cognitive Impairments of Alzheimer's Disease in the BALB/c Mice.Proteomic analysis of the lungs of mice infected with different pathotypes of H5N1 avian influenza viruses.Recombinant IFN-γ from the bank vole Myodes glareolus: a novel tool for research on rodent reservoirs of zoonotic pathogens.Mechanisms of interferon-beta-induced inhibition of Toxoplasma gondii growth in murine macrophages and embryonic fibroblasts: role of immunity-related GTPase M1.Antimicrobial effects of murine mesenchymal stromal cells directed against Toxoplasma gondii and Neospora caninum: role of immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs)In astrocytes the accumulation of the immunity-related GTPases Irga6 and Irgb6 at the vacuole of Toxoplasma gondii is dependent on the parasite virulence

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P2860

The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens.

http://www.wikidata.org/entity/Q33940781

description

2011 nî lūn-bûn

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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2011 թվականի հունիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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The IFN-γ-inducible GTPase, Ir ...... other intracellular pathogens.

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Esther von Stebut

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Frank Kaiser

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Frederik Heinrich

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Melba Muñoz

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Michael Saeftel

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P2860

A dedicated promoter drives constitutive expression of the cell-autonomous immune resistance GTPase, Irga6 (IIGP1) in mouse liver

The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage.

Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell death

IFN-gamma-inducible Irga6 mediates host resistance against Chlamydia trachomatis via autophagy

Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases.

Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole

Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence

Toxoplasma gondii: from animals to humans

Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP

How cells respond to interferons

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Stefan Kaufmann

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21698150

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Toxoplasma gondii

Plasmodium berghei

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3117789

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