Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis.
about
Redistribution of DAT/α-synuclein complexes visualized by "in situ" proximity ligation assay in transgenic mice modelling early Parkinson's diseaseDopamine transporter cell surface localization facilitated by a direct interaction with the dopamine D2 receptorIdentification of Heat Shock Protein 60 as a Regulator of Neutral Sphingomyelinase 2 and Its Role in Dopamine UptakeThe role of oxidative stress in Parkinson's diseaseGenetics of Parkinson diseaseMechanisms of dopamine transporter regulation in normal and disease statesSynucleins antagonize endoplasmic reticulum function to modulate dopamine transporter traffickingAge-dependent effects of A53T alpha-synuclein on behavior and dopaminergic functionThe Synaptic Function of α-SynucleinThe contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's diseaseAlpha-synuclein structure, functions, and interactionsTetraspanin (TSP-17) protects dopaminergic neurons against 6-OHDA-induced neurodegeneration in C. elegansRegulation of dopamine transporter activity by carboxypeptidase EAlpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cellsIncreased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synucleinCerebrospinal fluid α-synuclein predicts cognitive decline in Parkinson disease progression in the DATATOP cohort.From QTL to candidate gene: a genetic approach to alcoholism researchNeurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans.Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice.GPR37 associates with the dopamine transporter to modulate dopamine uptake and behavioral responses to dopaminergic drugs.Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.Forward genetic analysis to identify determinants of dopamine signaling in Caenorhabditis elegans using swimming-induced paralysisModulation of alpha-synuclein aggregation by dopamine analogs.Alpha-synuclein overexpression increases dopamine toxicity in BE2-M17 cellsCaenorhabditis elegans: a model to investigate oxidative stress and metal dyshomeostasis in Parkinson's diseaseThe chaperone-like activity of α-synuclein attenuates aggregation of its alternatively spliced isoform, 112-synuclein in vitro: plausible cross-talk between isoforms in protein aggregation.Decreased Expression of α-Synuclein, Nogo-A and UCH-L1 in Patients with Schizophrenia: A Preliminary Serum Study.Convergent evidence for abnormal striatal synaptic plasticity in dystonia.The neurotoxicity of DOPAL: behavioral and stereological evidence for its role in Parkinson disease pathogenesis.Mice expressing the A53T mutant form of human alpha-synuclein exhibit hyperactivity and reduced anxiety-like behaviorKinase-dependent Regulation of Monoamine Neurotransmitter Transporters.Parkin and alpha-synuclein: opponent actions in the pathogenesis of Parkinson's disease.Discovery of 3-Arylcoumarin-tetracyclic Tacrine Hybrids as Multifunctional Agents against Parkinson's Diseasealpha-Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease.Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.Quantification of alpha-synuclein binding to lipid vesicles using fluorescence correlation spectroscopyRegulation of the Dopamine and Vesicular Monoamine Transporters: Pharmacological Targets and Implications for Disease.Novel therapeutic approaches in multiple system atrophyBiochemical and morphological consequences of human α-synuclein expression in a mouse α-synuclein null background.Alpha-synuclein function and dysfunction on cellular membranes.
P2860
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P2860
Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis.
description
2001 nî lūn-bûn
@nan
2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Direct binding and functional ...... te dopamine-induced apoptosis.
@ast
Direct binding and functional ...... te dopamine-induced apoptosis.
@en
type
label
Direct binding and functional ...... te dopamine-induced apoptosis.
@ast
Direct binding and functional ...... te dopamine-induced apoptosis.
@en
prefLabel
Direct binding and functional ...... te dopamine-induced apoptosis.
@ast
Direct binding and functional ...... te dopamine-induced apoptosis.
@en
P2093
P356
P1433
P1476
Direct binding and functional ...... ate dopamine-induced apoptosis
@en
P2093
P304
P356
10.1096/FJ.00-0334COM
P407
P50
P577
2001-04-01T00:00:00Z