Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells
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Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1Dynamic structural flexibility of α-synucleinThe contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's diseasePreclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-MitoxyIncreased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synucleinMorphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal systemAlpha-synuclein overexpression increases dopamine toxicity in BE2-M17 cellsAlpha-synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans.DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity.Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo.Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family.The effect of environmental enrichment on substantia nigra gene expression after traumatic brain injury in rats.14-3-3zeta contributes to tyrosine hydroxylase activity in MN9D cells: localization of dopamine regulatory proteins to mitochondria.Calpain-mediated signaling mechanisms in neuronal injury and neurodegenerationFTY720/Fingolimod Reduces Synucleinopathy and Improves Gut Motility in A53T Mice: CONTRIBUTIONS OF PRO-BRAIN-DERIVED NEUROTROPHIC FACTOR (PRO-BDNF) AND MATURE BDNF.α-Synuclein and dopamine at the crossroads of Parkinson's diseaseLeucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson's disease?Loss of functional alpha-synuclein: a toxic event in Parkinson's disease?Models of α-synuclein aggregation in Parkinson's disease.Insights on the interaction of alpha-synuclein and metals in the pathophysiology of Parkinson's disease.Effect of amyloids on the vesicular machinery: implications for somatic neurotransmission.Recombinant α- β- and γ-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free Assays.Effects of methylmercury on dopamine release in MN9D neuronal cells.Alpha-synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: lessons from viral transduction of knockout mice.Protein phosphatase 2A is involved in the tyrosine hydroxylase phosphorylation regulated by α-synuclein.Ceftriaxone attenuates acute cocaine-evoked dopaminergic neurotransmission in the nucleus accumbens of the rat.Aromatic L-amino acid decarboxylase phosphorylation and activation by PKGIalpha in vitro.Non-motor parkinsonian pathology in aging A53T α-synuclein mice is associated with progressive synucleinopathy and altered enzymatic function.Evidence of oxidative stress in young and aged DJ-1-deficient mice.Longitudinal evolution of compensatory changes in striatal dopamine processing in Parkinson's disease.Exogenous α-Synuclein Monomers Alter Dopamine Metabolism in Murine Brain.Dopaminergic lesioning impairs adult hippocampal neurogenesis by distinct modification of α-synuclein.Phosphorylation of pyridoxal 5'-phosphate enzymes: an intriguing and neglected topic.A Focus on the Beneficial Effects of Alpha Synuclein and a Re-appraisal of Synucleinopathies.Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity.Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease.Can Interactions Between α-Synuclein, Dopamine and Calcium Explain Selective Neurodegeneration in Parkinson's Disease?
P2860
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P2860
Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells
description
2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
scientific journal article
@en
vedecký článok (publikovaný 2006/11/01)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/11/01)
@nl
наукова стаття, опублікована в листопаді 2006
@uk
مقالة علمية (نشرت في نوفمبر 2006)
@ar
name
Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells
@ast
Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells
@en
Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells
@nl
type
label
Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells
@ast
Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells
@en
Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells
@nl
prefLabel
Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells
@ast
Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells
@en
Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells
@nl
P2093
P2860
P3181
P1476
Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells
@en
P2093
Amber D. Van Laar
Roya Tehranian
Ruth G. Perez
Susana E. Montoya
Teresa G. Hastings
P2860
P304
P3181
P356
10.1111/J.1471-4159.2006.04146.X
P407
P577
2006-11-01T00:00:00Z