The US3 protein kinase of herpes simplex virus 1 mediates the posttranslational modification of BAD and prevents BAD-induced programmed cell death in the absence of other viral proteins.
about
BAD is a pro-survival factor prior to activation of its pro-apoptotic functionMapping of key functions of the herpes simplex virus 1 U(S)3 protein kinase: the U(S)3 protein can form functional heteromultimeric structures derived from overlapping truncated polypeptidesThe interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathwaysRole of ND10 nuclear bodies in the chromatin repression of HSV-1Bovine Herpes Virus 1 (BHV-1) and Herpes Simplex Virus Type 1 (HSV-1) Promote Survival of Latently Infected Sensory Neurons, in Part by Inhibiting ApoptosisSubversion of Cell Signaling Pathways by Hepatitis C Virus Nonstructural 5A Protein via Interaction with Grb2 and P85 Phosphatidylinositol 3-KinaseNecroptosis: The Trojan horse in cell autonomous antiviral host defenseNucleocytoplasmic shuttling of the HSV-2 serine/threonine kinase Us3Phosphorylation of cytokeratin 17 by herpes simplex virus type 2 US3 protein kinase.Effects of phosphorylation of herpes simplex virus 1 envelope glycoprotein B by Us3 kinase in vivo and in vitroTowards an understanding of the herpes simplex virus type 1 latency-reactivation cycleHerpes simplex virus protein kinases US3 and UL13 modulate VP11/12 phosphorylation, virion packaging, and phosphatidylinositol 3-kinase/Akt signaling activityThe suppression of apoptosis by α-herpesvirus.Herpes simplex virus 1 ICP22 regulates the accumulation of a shorter mRNA and of a truncated US3 protein kinase that exhibits altered functionsHerpes simplex virus 1 protein kinase US3 hyperphosphorylates p65/RelA and dampens NF-κB activation.T-cell tropism and the role of ORF66 protein in pathogenesis of varicella-zoster virus infectionHerpes simplex virus 1-encoded protein kinase UL13 phosphorylates viral Us3 protein kinase and regulates nuclear localization of viral envelopment factors UL34 and UL31Roles for herpes simplex virus type 1 UL34 and US3 proteins in disrupting the nuclear lamina during herpes simplex virus type 1 egress.U(S)3 protein kinase of herpes simplex virus 1 blocks caspase 3 activation induced by the products of U(S)1.5 and U(L)13 genes and modulates expression of transduced U(S)1.5 open reading frame in a cell type-specific manner.Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replicationProtein kinase B/Akt is present in activated form throughout the entire replicative cycle of deltaU(S)3 mutant virus but only at early times after infection with wild-type herpes simplex virus 1U(S)3 and U(S)3.5 protein kinases of herpes simplex virus 1 differ with respect to their functions in blocking apoptosis and in virion maturation and egress.ICP0 and the US3 protein kinase of herpes simplex virus 1 independently block histone deacetylation to enable gene expression.Infection of cattle with a bovine herpesvirus 1 strain that contains a mutation in the latency-related gene leads to increased apoptosis in trigeminal ganglia during the transition from acute infection to latency.Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cellsThe herpes simplex virus 1 US3 protein kinase blocks caspase-dependent double cleavage and activation of the proapoptotic protein BADHerpes simplex virus 1 precludes replenishment of the short-lived receptor of tumor necrosis factor alpha by virion host shutoff-dependent degradation of its mRNA.Herpes simplex virus type 1 and bovine herpesvirus 1 latency.Herpes simplex virus 1 protein kinase Us3 and major tegument protein UL47 reciprocally regulate their subcellular localization in infected cells.Herpes simplex virus protein kinase US3 activates and functionally overlaps protein kinase A to block apoptosisHerpes simplex virus infection and apoptosis.Phylogenetically Distant Viruses Use the Same BH3-Only Protein Puma to Trigger Bax/Bak-Dependent Apoptosis of Infected Mouse and Human Cells.The UL13 and US3 Protein Kinases of Herpes Simplex Virus 1 Cooperate to Promote the Assembly and Release of Mature, Infectious Virions.Bcl-2 blocks accretion or depletion of stored calcium but has no effect on the redistribution of IP3 receptor I mediated by glycoprotein E of herpes simplex virus 1.Ocular and neuronal cell apoptosis during HSV-1 infection: a review.Virulence genes in herpes simplex virus type 1 corneal infection.In transduced cells, the US3 protein kinase of herpes simplex virus 1 precludes activation and induction of apoptosis by transfected procaspase 3.Role of group A p21-activated kinases in the anti-apoptotic activity of the pseudorabies virus US3 protein kinase.Characterization of a Herpes Simplex Virus 1 (HSV-1) Chimera in Which the Us3 Protein Kinase Gene Is Replaced with the HSV-2 Us3 Gene.Identification of a physiological phosphorylation site of the herpes simplex virus 1-encoded protein kinase Us3 which regulates its optimal catalytic activity in vitro and influences its function in infected cells.
P2860
Q24298421-4FBA2A3D-9789-45C9-B0E9-87E325CED35EQ24675678-3FF7F10D-48C6-46EC-ACD4-56D294D28685Q26751441-970AADDA-5F46-4243-9574-986C2F53671CQ26751443-D9704EF9-72D2-49AE-AC02-308742DFD45DQ26864175-1D37DA19-A65E-43BA-8BA1-BB11FB789926Q27472897-3B2085D6-028B-4AD6-95EE-4D25F631B7A2Q28087723-C88A4D80-3727-47EA-A4C5-12933D65AA16Q30503332-96802CFB-C7D3-4370-BB78-745AF5338F06Q31121143-1308BA92-0AA9-4ED0-AC64-CCF47895B22DQ33558633-052B4E59-E0E8-4309-B6CD-CCDC67773CECQ33654414-F9236C4F-5C28-4BD1-8E72-C56BBA9F3144Q33743987-01E8C500-8DE9-4857-AB48-3134C1901D2DQ33815866-535EDDF0-42D4-474D-BDBE-2818A8BDACA8Q33843248-2C6EE52E-9750-4ECE-A561-FB96FA0DBB72Q33900418-796617B9-B0C8-410C-9621-F20DFC658F9AQ34045556-39BFF32F-7097-4433-90B0-47F68FB80A07Q34302174-2C7F6037-EA84-4B48-9607-881D37794AB7Q34357194-6FE48713-7FC6-4B71-B404-60AD1D63EFA8Q34358090-5867B0AA-B556-4694-9E6C-455D2CC2D549Q34362395-C11DC845-C5A3-426E-B151-0AE152E84375Q34545781-DA579620-1B51-4CF7-A7FD-31245F06AAE2Q34545887-162911B5-4C05-4B8F-9D24-A828054ACCEFQ34773141-A3818AC4-FCF4-48DD-AFEF-11D2E66D8658Q34860529-7B55E352-CF7C-4373-8D28-881BD99E1EC7Q34951110-CD4E6741-F843-4E13-B0FE-5D11E41404A7Q34997331-764C5057-9FF3-46B3-A272-3A4E26F182AEQ35023681-CA37EC39-34B3-4A64-8F18-357D6F403ACCQ35044114-50D38D59-CAA1-44B1-A3C4-CFA29BEF9878Q35192686-749B270F-5254-416C-A508-C243FEC44015Q35320264-38CB2C3F-62FE-4A8B-B4F3-B2E66B5F9408Q35613809-8318D7D8-95FF-450E-AE79-28A90F3AC5E0Q35648476-0D20FD69-0F2B-4301-8D0A-0777DE9D149CQ35675713-4847F250-B37B-4146-A6A4-C3265F8BBAB4Q35857308-8B2B4B7D-6322-4029-A935-B14CDD5289E8Q35932186-785BBE1B-BCA8-4AEB-A7D8-3511B7E111B1Q35932197-10F2D471-455F-4C5E-AAC1-A27B76BC2F55Q36099157-CBDA3310-B2E1-4195-B700-53A15622B690Q36336975-3CD5D352-1308-428A-A7F9-B7739E9CB9FBQ36433841-775EA64E-DDD6-4B71-B102-290D44BB215EQ36748068-A62F9C0D-F097-4E4E-A709-9442CB1B6937
P2860
The US3 protein kinase of herpes simplex virus 1 mediates the posttranslational modification of BAD and prevents BAD-induced programmed cell death in the absence of other viral proteins.
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The US3 protein kinase of herp ...... sence of other viral proteins.
@ast
The US3 protein kinase of herp ...... sence of other viral proteins.
@en
type
label
The US3 protein kinase of herp ...... sence of other viral proteins.
@ast
The US3 protein kinase of herp ...... sence of other viral proteins.
@en
prefLabel
The US3 protein kinase of herp ...... sence of other viral proteins.
@ast
The US3 protein kinase of herp ...... sence of other viral proteins.
@en
P2860
P356
P1476
The US3 protein kinase of herp ...... sence of other viral proteins.
@en
P2093
P2860
P304
10410-10415
P356
10.1073/PNAS.181344498
P407
P577
2001-08-21T00:00:00Z