Structure of AMA1 from Plasmodium falciparum reveals a clustering of polymorphisms that surround a conserved hydrophobic pocket. - Wikidata - awgldk - TriplyDB

Structure of AMA1 from Plasmodium falciparum reveals a clustering of polymorphisms that surround a conserved hydrophobic pocket.

Structure of AMA1 from Plasmodium falciparum reveals a clustering of polymorphisms that surround a conserved hydrophobic pocket.

http://www.wikidata.org/entity/Q33943794

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Applications of (19)F-NMR in Fragment-Based Drug Discovery Conditional expression of apical membrane antigen 1 in Plasmodium falciparum shows it is required for erythrocyte invasion by merozoites Protein kinase a dependent phosphorylation of apical membrane antigen 1 plays an important role in erythrocyte invasion by the malaria parasite Structure of the Malaria Antigen AMA1 in Complex with a Growth-Inhibitory Antibody The Structure of a Chondroitin Sulfate-binding Domain Important in Placental Malaria Structural Characterization of Apical Membrane Antigen 1 (AMA1) from Toxoplasma gondii Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide Babesia divergensandNeospora caninumapical membrane antigen 1 structures reveal selectivity and plasticity in apicomplexan parasite host cell invasion PAN-modular structure of microneme protein SML-2 from the parasite Sarcocystis muris at 1.95 Å resolution and its complex with 1-thio-β-D-galactose Toxoplasma gondii Sporozoites Invade Host Cells Using Two Novel Paralogues of RON2 and AMA1 Structural and Functional Insights into the Malaria Parasite Moving Junction Complex Effectiveness of a serological tool to predict malaria transmission intensity in an elimination setting Molecular insights into the interaction between Plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide Humoral immune responses to a single allele PfAMA1 vaccine in healthy malaria-naïve adults The RON2-AMA1 interaction is a critical step in moving junction-dependent invasion by apicomplexan parasites High antibody titer against apical membrane antigen-1 is required to protect against malaria in the Aotus model Insights into the Immunological Properties of Intrinsically Disordered Malaria Proteins Using Proteome Scale Predictions.Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion.Humoral immune response to mixed PfAMA1 alleles; multivalent PfAMA1 vaccines induce broad specificity.Transcriptome of Aphanomyces euteiches: new oomycete putative pathogenicity factors and metabolic pathways Mimotopes of apical membrane antigen 1: Structures of phage-derived peptides recognized by the inhibitory monoclonal antibody 4G2dc1 and design of a more active analogue Protection of rhesus monkeys by a DNA prime/poxvirus boost malaria vaccine depends on optimal DNA priming and inclusion of blood stage antigens.Identification and characterization of the Plasmodium yoelii PyP140/RON4 protein, an orthologue of Toxoplasma gondii RON4, whose cysteine-rich domain does not protect against lethal parasite challenge infection An inhibitory antibody blocks interactions between components of the malarial invasion machinery.Sequence conservation in Plasmodium falciparum alpha-helical coiled coil domains proposed for vaccine development.Extreme polymorphism in a vaccine antigen and risk of clinical malaria: implications for vaccine development.Mapping epitopes of the Plasmodium vivax Duffy binding protein with naturally acquired inhibitory antibodies.Peptide inhibitors of the malaria surface protein, apical membrane antigen 1: identification of key binding residues Immunization with the Malaria Diversity-Covering Blood-Stage Vaccine Candidate Plasmodium falciparum Apical Membrane Antigen 1 DiCo in Complex with Its Natural Ligand PfRon2 Does Not Improve the In Vitro Efficacy.Distinct patterns of diversity, population structure and evolution in the AMA1 genes of sympatric Plasmodium falciparum and Plasmodium vivax populations of Papua New Guinea from an area of similarly high transmission Determination of the molecular basis for a limited dimorphism, N417K, in the Plasmodium vivax Duffy-binding protein.Strategies for designing and monitoring malaria vaccines targeting diverse antigens Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein High affinity antibodies to Plasmodium falciparum merozoite antigens are associated with protection from malaria.Transcriptome sequencing and analysis of Plasmodium gallinaceum reveals polymorphisms and selection on the apical membrane antigen-1.Allelic diversity and naturally acquired allele-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 in Kenya Genetic variability and natural selection at the ligand domain of the Duffy binding protein in Brazilian Plasmodium vivax populations.Cheminformatics Based Machine Learning Models for AMA1-RON2 Abrogators for Inhibiting Plasmodium falciparum Erythrocyte Invasion.Use of immunodampening to overcome diversity in the malarial vaccine candidate apical membrane antigen 1.

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P2860

Structure of AMA1 from Plasmodium falciparum reveals a clustering of polymorphisms that surround a conserved hydrophobic pocket.

http://www.wikidata.org/entity/Q33943794

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Structure of AMA1 from Plasmod ...... conserved hydrophobic pocket.

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Structure of AMA1 from Plasmod ...... conserved hydrophobic pocket.

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Proceedings of the National Academy of Sciences of the United States of America

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Structure of AMA1 from Plasmod ...... conserved hydrophobic pocket.

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Aditi Gupta

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Adrian H Batchelor

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Michael Becker

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Phillip Strike

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Tao Bai

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Vince J Murphy

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P2860

The economic and social burden of malaria

Genome sequence of the human malaria parasite Plasmodium falciparum

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

PROCHECK: a program to check the stereochemical quality of protein structures

Processing of X-ray diffraction data collected in oscillation mode

The atomic-resolution structure of a novel bacterial esterase

The structure of leech anti-platelet protein, an inhibitor of haemostasis

Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor.

Structure of domain III of the blood-stage malaria vaccine candidate, Plasmodium falciparum apical membrane antigen 1 (AMA1)

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12736-12741

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36

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102

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Robin Fredric Anders

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7630776

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Plasmodium falciparum

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1200259

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