An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease.
about
The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy.Striatal overexpression of DeltaFosB reproduces chronic levodopa-induced involuntary movementsMitochondrial biology and Parkinson's diseaseApaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicityEffect of zinc and paraquat co-exposure on neurodegeneration: Modulation of oxidative stress and expression of metallothioneins, toxicant responsive and transporter genes in ratsHuman gene therapy and imaging in neurological diseases.Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis.Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig's disease in rats via TDP-43 overexpression.Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damageTransduction profiles of recombinant adeno-associated virus vectors derived from serotypes 2 and 5 in the nigrostriatal system of rats.Advances in gene therapy for movement disorders.Neuroprotective gene therapy against acute neurological insults.Physiological and pathological roles of Apaf1 and the apoptosome.Gene therapy progress and prospects: Parkinson's disease.Gene therapy for Parkinson's disease using recombinant adeno-associated viral vectors.Adeno-associated virus vectors: potential applications for cancer gene therapy.Altered gene expression profiles reveal similarities and differences between Parkinson disease and model systems.Immunology of neurological gene therapy: how T cells modulate viral vector-mediated therapeutic transgene expression through immunological synapsesPromotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults.Molecular pathways of programmed cell death in experimental Parkinson's disease.Adeno-associated virus-2 and its primary cellular receptor--Cryo-EM structure of a heparin complex.Innate and adaptive immunity for the pathobiology of Parkinson's diseaseMolecules that modulate Apaf-1 activity.MPTP mouse models of Parkinson's disease: an update.Polypharmacology of small molecules targeting the ubiquitin-proteasome and ubiquitin-like systems.Glycoprotein NMB: an Emerging Role in Neurodegenerative Disease.Apaf1 inhibition promotes cell recovery from apoptosis.The role of the MYD88-dependent pathway in MPTP-induced brain dopaminergic degenerationGene therapy targeting mitochondrial pathway in Parkinson's disease.BAG1 is neuroprotective in in vivo and in vitro models of Parkinson's disease.p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.Minocycline inhibits cell death and decreases mutant Huntingtin aggregation by targeting Apaf-1.Apocytochrome c blocks caspase-9 activation and Bax-induced apoptosis.Hepatocyte growth factor receptor is a coreceptor for adeno-associated virus type 2 infection.Expression of BCL-2 via adeno-associated virus vectors rescues thalamic neurons after visual cortex lesion in the adult rat.Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta, and expression of caspase-11 in mice.Recombinant human granulocyte colony-stimulating factor protects against MPTP-induced dopaminergic cell death in mice by altering Bcl-2/Bax expression levels.Attenuation of MPTP-induced neurotoxicity and locomotor dysfunction in Nucling-deficient mice via suppression of the apoptosome pathway.Loss of collapsin response mediator protein 4 suppresses dopaminergic neuron death in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease.Withania somnifera alleviates parkinsonian phenotypes by inhibiting apoptotic pathways in dopaminergic neurons.
P2860
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P2860
An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease.
description
2001 nî lūn-bûn
@nan
2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
An AAV-derived Apaf-1 dominant ...... erapy for Parkinson's disease.
@ast
An AAV-derived Apaf-1 dominant ...... erapy for Parkinson's disease.
@en
type
label
An AAV-derived Apaf-1 dominant ...... erapy for Parkinson's disease.
@ast
An AAV-derived Apaf-1 dominant ...... erapy for Parkinson's disease.
@en
prefLabel
An AAV-derived Apaf-1 dominant ...... erapy for Parkinson's disease.
@ast
An AAV-derived Apaf-1 dominant ...... erapy for Parkinson's disease.
@en
P2093
P2860
P356
P1476
An AAV-derived Apaf-1 dominant ...... erapy for Parkinson's disease.
@en
P2093
Hayakawa H
Mochizuki H
Shimo-Nakanishi Y
Tamayose K
P2860
P304
10918-10923
P356
10.1073/PNAS.191107398
P407
P577
2001-09-04T00:00:00Z