p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.
about
S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's diseaseDiscovery and optimization of small-molecule ligands for the CBP/p300 bromodomainsp53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibitionPathologies associated with the p53 response.p53 at a glance.Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: cross-talk with alpha-synuclein and implication for Parkinson's disease.Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damageOxidative stress, redox signalling and endothelial dysfunction in ageing-related neurodegenerative diseases: a role of NADPH oxidase 2.Genetic analysis of the FBXO42 gene in Chinese Han patients with Parkinson's disease.Cognitive impairments accompanying rodent mild traumatic brain injury involve p53-dependent neuronal cell death and are ameliorated by the tetrahydrobenzothiazole PFT-α.Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65Regulation of p53 function by lysine methylation.Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disordersImpact of exercise on mitochondrial transcription factor expression and damage in the striatum of a chronic mouse model of Parkinson's diseaseTwo molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease.Ageing and neuronal vulnerability.p53 and disease: when the guardian angel fails.Calcium-dependent intracellular signal pathways in primary cultured adipocytes and ANK3 gene variation in patients with bipolar disorder and healthy controls.MPP+-induces PUMA- and p53-dependent, but ATF3-independent cell death.Dangerous habits of a security guard: the two faces of p53 as a drug target.GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism.Enhanced survival of dopaminergic neuronal transplants in hemiparkinsonian rats by the p53 inactivator PFT-αDelayed treatment with a p53 inhibitor enhances recovery in stroke brainCell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps.Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6.Post-trauma administration of the pifithrin-α oxygen analog improves histological and functional outcomes after experimental traumatic brain injury.The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's diseasep53-targeted cancer pharmacotherapy: move towards small molecule compounds.Programmed cell death in Parkinson's diseaseAtractylenolide-I Protects Human SH-SY5Y Cells from 1-Methyl-4-Phenylpyridinium-Induced Apoptotic Cell Death.SIRT1 Protects Human Lens Epithelial Cells Against Oxidative Stress by Inhibiting p53-Dependent Apoptosis.Pifithrin-α provides neuroprotective effects at the level of mitochondria independently of p53 inhibition.The pharmacological regulation of cellular mitophagy.Upregulation of sestrin-2 expression via P53 protects against 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity.Parkinson's disease: genetics and beyond.Post-traumatic administration of the p53 inactivator pifithrin-α oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury.p38(MAPK)/p53 signalling axis mediates neuronal apoptosis in response to tetrahydrobiopterin-induced oxidative stress and glucose uptake inhibition: implication for neurodegeneration.Anti-apoptotic effect of Mao-B inhibitor PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is mediated by p53 pathway inhibition in MPP+-treated SH-SY5Y human dopaminergic cells.Paraquat-induced apoptosis in human neuroblastoma SH-SY5Y cells: involvement of p53 and mitochondria.6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA.
P2860
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P2860
p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.
@en
p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.
@nl
type
label
p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.
@en
p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.
@nl
prefLabel
p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.
@en
p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.
@nl
P2093
P2860
P356
P1433
P1476
p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.
@en
P2093
Bruce Ladenheim
Jean Lud Cadet
Nigel H Greig
Qian-sheng Yu
Roy G Cutler
Wenzhen Duan
Xiaoxiang Zhu
Zhihong Guo
P2860
P304
P356
10.1002/ANA.10350
P50
P577
2002-11-01T00:00:00Z