p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism. - Wikidata - awgldk - TriplyDB

p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.

p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.

http://www.wikidata.org/entity/Q39401687

about

S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's disease Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition Pathologies associated with the p53 response.p53 at a glance.Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: cross-talk with alpha-synuclein and implication for Parkinson's disease.Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage Oxidative stress, redox signalling and endothelial dysfunction in ageing-related neurodegenerative diseases: a role of NADPH oxidase 2.Genetic analysis of the FBXO42 gene in Chinese Han patients with Parkinson's disease.Cognitive impairments accompanying rodent mild traumatic brain injury involve p53-dependent neuronal cell death and are ameliorated by the tetrahydrobenzothiazole PFT-α.Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65 Regulation of p53 function by lysine methylation.Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders Impact of exercise on mitochondrial transcription factor expression and damage in the striatum of a chronic mouse model of Parkinson's disease Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease.Ageing and neuronal vulnerability.p53 and disease: when the guardian angel fails.Calcium-dependent intracellular signal pathways in primary cultured adipocytes and ANK3 gene variation in patients with bipolar disorder and healthy controls.MPP+-induces PUMA- and p53-dependent, but ATF3-independent cell death.Dangerous habits of a security guard: the two faces of p53 as a drug target.GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism.Enhanced survival of dopaminergic neuronal transplants in hemiparkinsonian rats by the p53 inactivator PFT-α Delayed treatment with a p53 inhibitor enhances recovery in stroke brain Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps.Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6.Post-trauma administration of the pifithrin-α oxygen analog improves histological and functional outcomes after experimental traumatic brain injury.The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease p53-targeted cancer pharmacotherapy: move towards small molecule compounds.Programmed cell death in Parkinson's disease Atractylenolide-I Protects Human SH-SY5Y Cells from 1-Methyl-4-Phenylpyridinium-Induced Apoptotic Cell Death.SIRT1 Protects Human Lens Epithelial Cells Against Oxidative Stress by Inhibiting p53-Dependent Apoptosis.Pifithrin-α provides neuroprotective effects at the level of mitochondria independently of p53 inhibition.The pharmacological regulation of cellular mitophagy.Upregulation of sestrin-2 expression via P53 protects against 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity.Parkinson's disease: genetics and beyond.Post-traumatic administration of the p53 inactivator pifithrin-α oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury.p38(MAPK)/p53 signalling axis mediates neuronal apoptosis in response to tetrahydrobiopterin-induced oxidative stress and glucose uptake inhibition: implication for neurodegeneration.Anti-apoptotic effect of Mao-B inhibitor PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is mediated by p53 pathway inhibition in MPP+-treated SH-SY5Y human dopaminergic cells.Paraquat-induced apoptosis in human neuroblastoma SH-SY5Y cells: involvement of p53 and mitochondria.6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA.

P2860

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P2860

p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.

http://www.wikidata.org/entity/Q39401687

description

2002 nî lūn-bûn

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

@zh-tw

2002年论文

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2002年论文

@zh

2002年论文

@zh-cn

name

p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.

@en

p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.

@nl

type

label

p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.

@en

p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.

@nl

prefLabel

p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.

@en

p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.

@nl

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P1433

Annals of Neurology

P1476

p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.

@en

P2093

Bruce Ladenheim

http://www.w3.org/2001/XMLSchema#string

Jean Lud Cadet

http://www.w3.org/2001/XMLSchema#string

Jon Oyler

http://www.w3.org/2001/XMLSchema#string

Nigel H Greig

http://www.w3.org/2001/XMLSchema#string

Qian-sheng Yu

http://www.w3.org/2001/XMLSchema#string

Roy G Cutler

http://www.w3.org/2001/XMLSchema#string

Wenzhen Duan

http://www.w3.org/2001/XMLSchema#string

Xiaoxiang Zhu

http://www.w3.org/2001/XMLSchema#string

Zhihong Guo

http://www.w3.org/2001/XMLSchema#string

P2860

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity.

The role of p53 in tumour suppression: lessons from mouse models.

Role of p53 family members in apoptosis.

Regulation of the G2/M transition by p53.

An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease.

P304

597-606

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scholarly article

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10.1002/ANA.10350

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5

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52

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P50

P577

2002-11-01T00:00:00Z

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P698

12402257

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P921

Parkinson's disease