Intracellular cholesterol trafficking: role of the NPC1 protein.
about
Niemann-Pick C1 disease: correlations between NPC1 mutations, levels of NPC1 protein, and phenotypes emphasize the functional significance of the putative sterol-sensing domain and of the cysteine-rich luminal loop.Intracellular cholesterol transportDRABAL: novel method to mine large high-throughput screening assays using Bayesian active learningActivation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cellsInteraction of hormone-sensitive lipase with steroidogenic acute regulatory protein: facilitation of cholesterol transfer in adrenalReceptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors.Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells.Multiple roles for sphingolipids in steroid hormone biosynthesisNiemann-Pick disease type C: spectrum of HE1 mutations and genotype/phenotype correlations in the NPC2 group.Insights into the mechanisms of sterol transport between organelles.GM2/GD2 and GM3 gangliosides have no effect on cellular cholesterol pools or turnover in normal or NPC1 mice.Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse.Macrophage cholesterol transport: a critical player in foam cell formation.Cessation of rapid late endosomal tubulovesicular trafficking in Niemann-Pick type C1 disease.Host but not parasite cholesterol controls Toxoplasma cell entry by modulating organelle discharge.ACAT1 regulates the dynamics of free cholesterols in plasma membrane which leads to the APP-α-processing alteration.Role of the steroidogenic acute regulatory protein in health and disease.Cholesterol reporter molecules.Aberrant promoter methylation profile of Niemann-pick type C1 gene in cardiovascular diseaseIntracellular sterol dynamicsPatched1 and Patched2 inhibit Smoothened non-cell autonomously.Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids.Visualization of cholesterol deposits in lysosomes of Niemann-Pick type C fibroblasts using recombinant perfringolysin O.Hexadecylphosphocholine interferes with the intracellular transport of cholesterol in HepG2 cells.Changes to cholesterol trafficking in macrophages by Leishmania parasites infection.Large-scale gene expression analysis of cholesterol dependence in NS0 cells.Post-translational processing of beta-secretase in Alzheimer's disease.Recycling compartments and the internal vesicles of multivesicular bodies harbor most of the cholesterol found in the endocytic pathway.Association between the rs1805081 polymorphism of Niemann-Pick type C1 gene and cardiovascular disease in a sample of an Iranian population.NPC1 late endosomes contain elevated levels of non-esterified ('free') fatty acids and an abnormally glycosylated form of the NPC2 protein.Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux.Vesicular and non-vesicular sterol transport in living cells. The endocytic recycling compartment is a major sterol storage organelle.Niemann-Pick type C disease: mutations of NPC1 gene and evidence of abnormal expression of some mutant alleles in fibroblasts.Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration.Cholesterol substrate pools and steroid hormone levels are normal in the face of mutational inactivation of NPC1 protein.Coxiella burnetii inhabits a cholesterol-rich vacuole and influences cellular cholesterol metabolism.Utility of rapid whole-exome sequencing in the diagnosis of Niemann-Pick disease type C presenting with fetal hydrops and acute liver failure.Receptor-mediated and bulk-phase endocytosis cause macrophage and cholesterol accumulation in Niemann-Pick C disease.Optimization of process parameters for supercritical fluid extraction of cholesterol from whole milk powder using ethanol as co-solvent.
P2860
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P2860
Intracellular cholesterol trafficking: role of the NPC1 protein.
description
2000 nî lūn-bûn
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2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Intracellular cholesterol trafficking: role of the NPC1 protein.
@ast
Intracellular cholesterol trafficking: role of the NPC1 protein.
@en
type
label
Intracellular cholesterol trafficking: role of the NPC1 protein.
@ast
Intracellular cholesterol trafficking: role of the NPC1 protein.
@en
prefLabel
Intracellular cholesterol trafficking: role of the NPC1 protein.
@ast
Intracellular cholesterol trafficking: role of the NPC1 protein.
@en
P1476
Intracellular cholesterol trafficking: role of the NPC1 protein.
@en
P2093
E J Blanchette-Mackie
P304
P356
10.1016/S1388-1981(00)00055-X
P407
P577
2000-06-01T00:00:00Z