Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux.
about
The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier diseaseEffect of host cell lipid metabolism on alphavirus replication, virion morphogenesis, and infectivityCathepsin D, a lysosomal protease, regulates ABCA1-mediated lipid effluxLate endosomal cholesterol accumulation leads to impaired intra-endosomal traffickingComparative analysis of acid sphingomyelinase distribution in the CNS of rats and mice following intracerebroventricular deliverySPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporterLoss of ABCG1 influences regulatory T cell differentiation and atherosclerosis.Acid sphingomyelinase activity triggers microparticle release from glial cells.Macrophage sphingomyelin synthase 2 deficiency decreases atherosclerosis in miceMyeloid cell-specific serine palmitoyltransferase subunit 2 haploinsufficiency reduces murine atherosclerosis.Lipid profile in adult patients with Fabry disease - Ten-year follow upHost-directed antimicrobial drugs with broad-spectrum efficacy against intracellular bacterial pathogens.Sphingomyelinases: enzymology and membrane activity.Gene transfer of human acid sphingomyelinase corrects neuropathology and motor deficits in a mouse model of Niemann-Pick type A disease.Transcriptomic signature of Leishmania infected mice macrophages: a metabolic point of view.Improvement in lipid and protein trafficking in Niemann-Pick C1 cells by correction of a secondary enzyme defect.Control of autophagy maturation by acid sphingomyelinase in mouse coronary arterial smooth muscle cells: protective role in atherosclerosisRegulation and mechanisms of macrophage cholesterol effluxConsequences of cellular cholesterol accumulation: basic concepts and physiological implicationsSphingolipid metabolism correlates with cerebrospinal fluid Beta amyloid levels in Alzheimer's diseaseRecent advances in the immunobiology of ceramide.Histone deacetylase inhibitors modulate KATP subunit transcription in HL-1 cardiomyocytes through effects on cholesterol homeostasis.Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2.Absorption and lipoprotein transport of sphingomyelin.Physiological and pathophysiological aspects of ceramide.Lysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy.Anomalous surface distribution of glycosyl phosphatidyl inositol-anchored proteins in neurons lacking acid sphingomyelinase.Inhibition of Acid Sphingomyelinase Depletes Cellular Phosphatidylserine and Mislocalizes K-Ras from the Plasma Membrane.Sphingomyelin in high-density lipoproteins: structural role and biological function.Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progressionAcid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice.Degradation and beyond: the macrophage lysosome as a nexus for nutrient sensing and processing in atherosclerosis.Liver-specific deficiency of serine palmitoyltransferase subunit 2 decreases plasma sphingomyelin and increases apolipoprotein E levels.Elevated endosomal cholesterol levels in Niemann-Pick cells inhibit rab4 and perturb membrane recyclingSterols and sphingolipids: dynamic duo or partners in crime?Acid sphingomyelinase in macrophage biology.Neural stem cell transplantation as a therapeutic approach for treating lysosomal storage diseases.ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full NPC1 activity.Increased ABCA1 activity protects against atherosclerosis.Glycosphingolipid accumulation inhibits cholesterol efflux via the ABCA1/apolipoprotein A-I pathway: 1-phenyl-2-decanoylamino-3-morpholino-1-propanol is a novel cholesterol efflux accelerator.
P2860
Q24306475-E4A1BF00-EFBE-4A7C-AE3B-230368759BDEQ27487100-6132C6E0-80A7-402C-BCB8-1E52486BB33CQ28267787-F7343B88-1ADA-49E3-BF4E-21D66C06362FQ28469288-FE152841-8EF6-4FBB-80B9-AEFF5451746DQ28476819-D1EE60CD-D489-43B8-9BEA-5F2AFA0F6A8FQ28506217-EC9A827F-2FA4-430F-B20F-8AFAE050A985Q30355065-E937AD09-6369-4B8A-8954-05801338B5EDQ30486802-25805FD4-0807-49A4-A5F4-018E4F305A2FQ30490333-9EFF5476-DD12-467B-949B-F1C8A104DDD4Q30538274-2E18C59C-E6E9-42B8-9C94-B7EAD3D745F5Q33904518-D6E486E0-5F87-4A9A-BC79-68C75CE57FC6Q34026297-A2CA20FE-501F-4656-9D76-2D0E49978D02Q34156320-89059E8D-7C58-44B0-9000-59E213B5B87BQ34202095-742A4FE5-6FDB-4DE3-B652-3740075F0BA1Q34396113-E254C3AC-A32F-4C88-A160-76C98D7EE8CAQ34399659-EBBCA059-8CC2-4CAB-8353-5EBE2C49BBB8Q34412400-C27DC4D7-5552-4A71-A783-39831227275FQ34798750-77D9EFF4-69D6-4667-9BAC-647EA94B8A53Q34949033-1AFA1543-043C-46B0-8799-8EEE911D3758Q35566575-138C29C2-1534-490D-A487-F4CA317E4362Q35916828-E216898D-648C-4B2B-8661-72771AC66FFFQ35947882-55D0F41F-6CA2-4886-AB60-9C7D1B40B4F0Q36097195-80E762F2-C853-49D9-A627-C074720CBBBBQ36298122-BF81995E-B30F-44C7-BF55-CDAED86B13C4Q36341274-10CBE87E-3F93-46A4-BC64-15A71CABBCE3Q36363960-8745DAF1-9DC1-46CA-BD61-8ED9F282E66FQ36438776-09A2DB00-A8C2-494A-B779-BE9711370960Q36480870-8257AFC2-4823-4517-84EC-2C41D1C8ED99Q36820504-C972F4CC-0912-4BCE-8A8C-5BE458614326Q36924524-9A0813AD-C911-431B-ADA4-8D6204BE5841Q37136747-A357887C-A711-4049-98BF-584A221013F3Q37265183-6F20B54C-B25F-40E4-8731-220F725B4548Q37446891-3F8FEB4F-9D74-4321-A1CD-ABF1A142025DQ37537956-DC62BAC6-A299-4B02-9E21-DFAB7D7F38BEQ37723587-8E033BB5-68B8-40B4-8531-2D4F6F019C84Q37870853-415EBA02-0FD1-40D1-A11C-EDD74BBC20A8Q37929618-6240A963-7A6B-4D0B-9A32-8D26DD490E66Q38363238-807990A8-B685-4B82-88BF-858EECBFDC7AQ39738088-D0FCDA44-1401-4405-86AA-F0FE44237223Q40423407-A065E843-38A4-4727-BB5A-C3A1707E8921
P2860
Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Acid sphingomyelinase-deficien ...... sterol trafficking and efflux.
@en
Acid sphingomyelinase-deficien ...... sterol trafficking and efflux.
@nl
type
label
Acid sphingomyelinase-deficien ...... sterol trafficking and efflux.
@en
Acid sphingomyelinase-deficien ...... sterol trafficking and efflux.
@nl
prefLabel
Acid sphingomyelinase-deficien ...... sterol trafficking and efflux.
@en
Acid sphingomyelinase-deficien ...... sterol trafficking and efflux.
@nl
P2093
P2860
P356
P1476
Acid sphingomyelinase-deficien ...... sterol trafficking and efflux.
@en
P2093
P2860
P304
44976-44983
P356
10.1074/JBC.M106455200
P407
P577
2001-09-28T00:00:00Z