A targeted dominant negative mutation of the thyroid hormone alpha 1 receptor causes increased mortality, infertility, and dwarfism in mice.
about
Molecular aspects of thyroid hormone actionsResistance to thyroid hormone due to defective thyroid receptor alphaClinical Consequences of Mutations in Thyroid Hormone Receptor-α1Role and Mechanisms of Actions of Thyroid Hormone on the Skeletal DevelopmentThe syndromes of reduced sensitivity to thyroid hormoneA thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in miceA dominant-negative thyroid hormone receptor blocks amphibian metamorphosis by retaining corepressors at target genes.Thyroid hormone receptors control developmental maturation of the middle ear and the size of the ossicular bonesAn unliganded thyroid hormone beta receptor activates the cyclin D1/cyclin-dependent kinase/retinoblastoma/E2F pathway and induces pituitary tumorigenesisThe thyroid hormone receptor alpha1 protein is expressed in embryonic postmitotic neurons and persists in most adult neurons.Luteal expression of thyroid hormone receptors during gestation and postpartum in the rat.Anxiety, memory impairment, and locomotor dysfunction caused by a mutant thyroid hormone receptor alpha1 can be ameliorated by T3 treatment.Thyroid hormone receptor α mutation causes a severe and thyroxine-resistant skeletal dysplasia in female mice.Retardation of post-natal development caused by a negatively acting thyroid hormone receptor alpha1Characterization of skeletal phenotypes of TRalpha1 and TRbeta mutant mice: implications for tissue thyroid status and T3 target gene expressionGlobal expression profiling reveals gain-of-function oncogenic activity of a mutated thyroid hormone receptor in thyroid carcinogenesis.Differential recruitment of nuclear coregulators directs the isoform-dependent action of mutant thyroid hormone receptors.Nutritionally-induced catch-up growthThyroid hormone receptor mutations in cancer and resistance to thyroid hormone: perspective and prognosisImpaired adipogenesis caused by a mutated thyroid hormone alpha1 receptor.Nongenomic activation of phosphatidylinositol 3-kinase signaling by thyroid hormone receptors.Advanced bone formation in mice with a dominant-negative mutation in the thyroid hormone receptor β gene due to activation of Wnt/β-catenin protein signaling.Thyroid hormone receptors and resistance to thyroid hormone disorders.New insights into regulation of lipid metabolism by thyroid hormone.NCoR1 regulates thyroid hormone receptor isoform-dependent adipogenesisThyroid hormone receptors regulate adipogenesis and carcinogenesis via crosstalk signaling with peroxisome proliferator-activated receptors.Adipogenesis is differentially impaired by thyroid hormone receptor mutant isoforms.Thyroid Hormone Receptor α Plays an Essential Role in Male Skeletal Muscle Myoblast Proliferation, Differentiation, and Response to InjuryA heartfelt response: new thyroid hormone-sensitive neurons in the hypothalamus.Role of Thyroid Hormones in Skeletal Development and Bone Maintenance.Nuclear receptor corepressor (NCOR1) regulates in vivo actions of a mutated thyroid hormone receptor αDistinct dysregulation of lipid metabolism by unliganded thyroid hormone receptor isoforms.Recruitment of N-CoR/SMRT-TBLR1 corepressor complex by unliganded thyroid hormone receptor for gene repression during frog development.Transgenic analysis reveals that thyroid hormone receptor is sufficient to mediate the thyroid hormone signal in frog metamorphosisA histone deacetylase inhibitor improves hypothyroidism caused by a TRα1 mutant.New insights into the role of thyroid hormone in cardiac remodeling: time to reconsider?Thyroid hormone action in metabolic regulation.Thyroid hormone actions in liver cancer.Different causes of reduced sensitivity to thyroid hormone: diagnosis and clinical management.The multiple effects of thyroid disorders on bone and mineral metabolism.
P2860
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P2860
A targeted dominant negative mutation of the thyroid hormone alpha 1 receptor causes increased mortality, infertility, and dwarfism in mice.
description
2001 nî lūn-bûn
@nan
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
A targeted dominant negative m ...... rtility, and dwarfism in mice.
@ast
A targeted dominant negative m ...... rtility, and dwarfism in mice.
@en
type
label
A targeted dominant negative m ...... rtility, and dwarfism in mice.
@ast
A targeted dominant negative m ...... rtility, and dwarfism in mice.
@en
prefLabel
A targeted dominant negative m ...... rtility, and dwarfism in mice.
@ast
A targeted dominant negative m ...... rtility, and dwarfism in mice.
@en
P2093
P2860
P356
P1476
A targeted dominant negative m ...... rtility, and dwarfism in mice.
@en
P2093
K Kaneshige
M C Willingham
M Kaneshige
P2860
P304
15095-15100
P356
10.1073/PNAS.261565798
P407
P577
2001-12-04T00:00:00Z