Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes.
about
Penicillium nalgiovense Laxa isolated from Antarctica is a new source of the antifungal metabolite amphotericin B.Reactive oxygen species-inducing antifungal agents and their activity against fungal biofilmsThe 1.92-A structure of Streptomyces coelicolor A3(2) CYP154C1. A new monooxygenase that functionalizes macrolide ring systemsStructural Studies of an A2-Type Modular Polyketide Synthase Ketoreductase Reveal Features Controlling α-Substituent StereochemistryEnzymatic methods for glyco(diversification/randomization) of drugs and small moleculesThe in vitro characterization of polyene glycosyltransferases AmphDI and NysDIA labile point in mutant amphotericin polyketide synthasesVariations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamilyPost-PKS tailoring steps of a disaccharide-containing polyene NPP in Pseudonocardia autotrophicaSelvamicin, an atypical antifungal polyene from two alternative genomic contextsStreptomyces muensis sp. nov.Availability of specific reductases controls the temporal activity of the cytochrome P450 complement of Streptomyces coelicolor A3(2).ASMPKS: an analysis system for modular polyketide synthasesIn situ detection of antibiotic amphotericin B produced in Streptomyces nodosus using Raman microspectroscopy.Investigation of cytochromes P450 in myxobacteria: excavation of cytochromes P450 from the genome of Sorangium cellulosum So ce56.Streptomyces hundungensis sp. nov., a novel actinomycete with antifungal activity and plant growth promoting traits.Role of active site water molecules and substrate hydroxyl groups in oxygen activation by cytochrome P450 158A2: a new mechanism of proton transfer.Biosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin.Biosynthetic mechanism for sunscreens of the biocontrol agent Lysobacter enzymogenes.Polyene antibiotic biosynthesis gene clusters.The enzymology of combinatorial biosynthesis.A systematic computational analysis of biosynthetic gene cluster evolution: lessons for engineering biosynthesisNew Rimocidin/CE-108 Derivatives Obtained by a Crotonyl-CoA Carboxylase/Reductase Gene Disruption in Streptomyces diastaticus var. 108: Substrates for the Polyene Carboxamide Synthase PcsA.The biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites.Exploiting Streptomyces coelicolor A3(2) P450s as a model for application in drug discovery.Tailoring the P450 monooxygenase gene for FR-008/candicidin biosynthesis.Community structure and antibiotic production of Streptomyces nodosus bioreactors cultured in liquid environments.Inactivation of an ABC transporter gene, mcyH, results in loss of microcystin production in the cyanobacterium Microcystis aeruginosa PCC 7806.Biosynthetic origin of butyrolactol A, an antifungal polyketide produced by a marine-derived Streptomyces.Probing the biology of natural products: molecular editing by diverted total synthesis.Biosynthesis and pathway engineering of antifungal polyene macrolides in actinomycetes.Clinical pharmacokinetics of inhaled antimicrobials.Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes.Genome Engineering and Modification Toward Synthetic Biology for the Production of Antibiotics.Vinylogous Dehydration by a Polyketide Dehydratase Domain in Curacin Biosynthesis.Nystatin biosynthesis and transport: nysH and nysG genes encoding a putative ABC transporter system in Streptomyces noursei ATCC 11455 are required for efficient conversion of 10-deoxynystatin to nystatin.Antifungal resistance and new strategies to control fungal infections.Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC.Identification of PimR as a positive regulator of pimaricin biosynthesis in Streptomyces natalensis.Characterization of the polyene macrolide P450 epoxidase from Streptomyces natalensis that converts de-epoxypimaricin into pimaricin.
P2860
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P2860
Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Amphotericin biosynthesis in S ...... etide synthase and late genes.
@ast
Amphotericin biosynthesis in S ...... etide synthase and late genes.
@en
type
label
Amphotericin biosynthesis in S ...... etide synthase and late genes.
@ast
Amphotericin biosynthesis in S ...... etide synthase and late genes.
@en
prefLabel
Amphotericin biosynthesis in S ...... etide synthase and late genes.
@ast
Amphotericin biosynthesis in S ...... etide synthase and late genes.
@en
P2093
P1476
Amphotericin biosynthesis in S ...... etide synthase and late genes.
@en
P2093
P304
P356
10.1016/S1074-5521(01)00046-1
P577
2001-07-01T00:00:00Z