Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC.
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The in vitro characterization of polyene glycosyltransferases AmphDI and NysDIPost-PKS tailoring steps of a disaccharide-containing polyene NPP in Pseudonocardia autotrophicaSelvamicin, an atypical antifungal polyene from two alternative genomic contextsStructure elucidation of degradation products of the antibiotic amoxicillin with ion trap MS(n) and accurate mass determination by ESI TOF.Insights into the biosynthesis of 12-membered resorcylic acid lactones from heterologous production in Saccharomyces cerevisiae.Nystatin induces secretion of interleukin (IL)-1beta, IL-8, and tumor necrosis factor alpha by a toll-like receptor-dependent mechanism.Structure-antifungal activity relationships of polyene antibiotics of the amphotericin B group.Novel Nystatin A₁ derivatives exhibiting low host cell toxicity and antifungal activity in an in vitro model of oral candidosis.Biosynthesis and pathway engineering of antifungal polyene macrolides in actinomycetes.Initiation of polyene macrolide biosynthesis: interplay between polyketide synthase domains and modules as revealed via domain swapping, mutagenesis, and heterologous complementation.New nystatin-related antifungal polyene macrolides with altered polyol region generated via biosynthetic engineering of Streptomyces noursei.Polyene macrolide biosynthesis in streptomycetes and related bacteria: recent advances from genome sequencing and experimental studies.New polyene macrolide family produced by submerged culture of Streptomyces durmitorensis.Nystatin biosynthesis and transport: nysH and nysG genes encoding a putative ABC transporter system in Streptomyces noursei ATCC 11455 are required for efficient conversion of 10-deoxynystatin to nystatin.Intracellular Metabolite Pool Changes in Response to Nutrient Depletion Induced Metabolic Switching in Streptomyces coelicolor.Insights into the evolution of macrolactam biosynthesis through cloning and comparative analysis of the biosynthetic gene cluster for a novel macrocyclic lactam, ML-449Characterization of the P450 monooxygenase NysL, responsible for C-10 hydroxylation during biosynthesis of the polyene macrolide antibiotic nystatin in Streptomyces noursei.Analysis of the mycosamine biosynthesis and attachment genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455.Synthesis and study of the antifungal activity of new mono- and disubstituted derivatives of a genetically engineered polyene antibiotic 28,29-didehydronystatin A1 (S44HP).Carboxyl-terminal domain characterization of polyene-specific P450 hydroxylase in Pseudonocardia autotrophica.Improved antibiotic production and silent gene activation in Streptomyces diastatochromogenes by ribosome engineering.Structural analysis and biosynthetic engineering of a solubility-improved and less-hemolytic nystatin-like polyene in Pseudonocardia autotrophica.Nystatin-like Pseudonocardia polyene B1, a novel disaccharide-containing antifungal heptaene antibiotic
P2860
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P2860
Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Chemical diversity of polyene ...... ered polyketide synthase NysC.
@en
type
label
Chemical diversity of polyene ...... ered polyketide synthase NysC.
@en
prefLabel
Chemical diversity of polyene ...... ered polyketide synthase NysC.
@en
P2093
P2860
P1476
Chemical diversity of polyene ...... tered polyketide synthase NysC
@en
P2093
Håvard Sletta
Jean-Marc Lancelin
Pascale Tsan
Per Bruheim
Sven E F Borgos
Trond E Ellingsen
P2860
P304
P356
10.1128/AAC.48.11.4120-4129.2004
P407
P577
2004-11-01T00:00:00Z