Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques.
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Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell TypesThe biased nucleotide composition of HIV-1 triggers type I interferon response and correlates with subtype D increased pathogenicityThe Curious Case of Type I IFN and MxA: Tipping the Immune Balance in AIDSNonpathogenic simian immunodeficiency virus infectionsNatural SIV hosts: showing AIDS the doorSimian Immunodeficiency Virus Infection of Chimpanzees (Pan troglodytes) Shares Features of Both Pathogenic and Non-pathogenic Lentiviral InfectionsInnate immune responses and rapid control of inflammation in African green monkeys treated or not with interferon-alpha during primary SIVagm infectionIntact type I Interferon production and IRF7 function in sooty mangabeysBlocking TLR7- and TLR9-mediated IFN-α production by plasmacytoid dendritic cells does not diminish immune activation in early SIV infectionAttenuation of pathogenic immune responses during infection with human and simian immunodeficiency virus (HIV/SIV) by the tetracycline derivative minocyclineImmune restoration after antiretroviral therapy: the pitfalls of hasty or incomplete repairs.Innate and Adaptive Immune Regulation During Chronic Viral InfectionsLoss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression.Innate sensing of HIV-infected cells.Innate immune recognition and activation during HIV infection.Residual immune dysregulation syndrome in treated HIV infection.Neutralizing antibodies inhibit HIV-1 infection of plasmacytoid dendritic cells by an FcγRIIa independent mechanism and do not diminish cytokines production.Acute plasma biomarkers of T cell activation set-point levels and of disease progression in HIV-1 infection.Targeting of type I interferon in systemic autoimmune diseasesCurrent humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis.Systems biology of natural simian immunodeficiency virus infectionsMultiple low-dose challenges in a rhesus macaque AIDS vaccine trial result in an evolving host response that affects protective outcomeInterferon-α is the primary plasma type-I IFN in HIV-1 infection and correlates with immune activation and disease markers.Different plasma markers of inflammation are influenced by immune recovery and cART composition or intensification in treated HIV infected individualsSpatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-α-producing and partially matured phenotypeHIV-associated chronic immune activation.Modulation of type I interferon-associated viral sensing during acute simian immunodeficiency virus infection in African green monkeys.Polymorphisms in interferon regulatory factor 7 reduce interferon-α responses of plasmacytoid dendritic cells to HIV-1.Efficient infection, activation, and impairment of pDCs in the BM and peripheral lymphoid organs during early HIV-1 infection in humanized rag2⁻/⁻γ C⁻/⁻ mice in vivo.Plasmacytoid dendritic cell dynamics tune interferon-alfa production in SIV-infected cynomolgus macaques.Early induction of polyfunctional simian immunodeficiency virus (SIV)-specific T lymphocytes and rapid disappearance of SIV from lymph nodes of sooty mangabeys during primary infection.Differential effects of HIV viral load and CD4 count on proliferation of naive and memory CD4 and CD8 T lymphocytes.Immunodeficiency lentiviral infections in natural and non-natural hosts.Strong viremia control in vaccinated macaques does not prevent gradual Th17 cell loss from central memory.Plasmacytoid dendritic cells are recruited to the colorectum and contribute to immune activation during pathogenic SIV infection in rhesus macaques.Plasmacytoid dendritic cells suppress HIV-1 replication but contribute to HIV-1 induced immunopathogenesis in humanized mice.Blocking type I interferon production: a new therapeutic option to reduce the HIV-1-induced immune activationBlockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infectionLow levels of SIV infection in sooty mangabey central memory CD⁴⁺ T cells are associated with limited CCR5 expression.Generalized immune activation and innate immune responses in simian immunodeficiency virus infection
P2860
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P2860
Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Downregulation of robust acute ...... infection of rhesus macaques.
@ast
Downregulation of robust acute ...... infection of rhesus macaques.
@en
type
label
Downregulation of robust acute ...... infection of rhesus macaques.
@ast
Downregulation of robust acute ...... infection of rhesus macaques.
@en
prefLabel
Downregulation of robust acute ...... infection of rhesus macaques.
@ast
Downregulation of robust acute ...... infection of rhesus macaques.
@en
P2093
P2860
P356
P1433
P1476
Downregulation of robust acute ...... infection of rhesus macaques.
@en
P2093
Brian Tabb
Daniel C Douek
Donald L Sodora
Guido Silvestri
Ivona Vasile-Pandrea
Jacob D Estes
Jason M Brenchley
Jeffrey Lifson
Levelle D Harris
Mirko Paiardini
P2860
P304
P356
10.1128/JVI.02612-09
P407
P577
2010-05-19T00:00:00Z