Establishment of irreversible growth arrest in myogenic differentiation requires the RB LXCXE-binding function.
about
RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrestNucleocytoplasmic shuttling of p130/RBL2: novel regulatory mechanism.Transcriptional repression by the retinoblastoma protein through the recruitment of a histone methyltransferaseCritical role of the Rb family in myoblast survival and fusionMolecular determinants for the complex formation between the retinoblastoma protein and LXCXE sequencesJumonji regulates cardiomyocyte proliferation via interaction with retinoblastoma proteinSeparation of anti-proliferation and anti-apoptotic functions of retinoblastoma protein through targeted mutations of its A/B domain.A SCARECROW-RETINOBLASTOMA protein network controls protective quiescence in the Arabidopsis root stem cell organizer.Cyclin D activates the Rb tumor suppressor by mono-phosphorylationcAMP-mediated inhibition of DNA replication and S phase progression: involvement of Rb, p21Cip1, and PCNA.Retinoblastoma protein and MyoD function together to effect the repression of Fra-1 and in turn cyclin D1 during terminal cell cycle arrest associated with myogenesis.Rescue of myogenic defects in Rb-deficient cells by inhibition of autophagy or by hypoxia-induced glycolytic shift.Rb-mediated chromatin structure regulation and transcriptional repression.Three regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteins.Active repression and E2F inhibition by pRB are biochemically distinguishable.Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytesMolecular Determinants for the Inactivation of the Retinoblastoma Tumor Suppressor by the Viral Cyclin-dependent Kinase UL97.Histone deacetylation of RB-responsive promoters: requisite for specific gene repression but dispensable for cell cycle inhibition.Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?Distinct mechanisms for repression of RNA polymerase III transcription by the retinoblastoma tumor suppressor protein.Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts.Low-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant rasHistone deacetylase-dependent transcriptional repression by pRB in yeast occurs independently of interaction through the LXCXE binding cleft.Opposing roles for DNA replication initiator proteins ORC1 and CDC6 in control of Cyclin E gene transcription.A functional connection between pRB and transforming growth factor beta in growth inhibition and mammary gland developmentAcetylation regulates the differentiation-specific functions of the retinoblastoma protein.Roles of pRB in the Regulation of Nucleosome and Chromatin Structures.RB restricts DNA damage-initiated tumorigenesis through an LXCXE-dependent mechanism of transcriptional control.Human cytomegalovirus-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins.Rb inhibits E2F-1-induced cell death in a LXCXE-dependent manner by active repression.Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4.Role of LXCXE motif-dependent interactions in the activity of the retinoblastoma protein.Retinoblastoma protein-mediated apoptosis after gamma-irradiation.Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes.
P2860
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P2860
Establishment of irreversible growth arrest in myogenic differentiation requires the RB LXCXE-binding function.
description
2000 nî lūn-bûn
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2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Establishment of irreversible ...... the RB LXCXE-binding function.
@ast
Establishment of irreversible ...... the RB LXCXE-binding function.
@en
type
label
Establishment of irreversible ...... the RB LXCXE-binding function.
@ast
Establishment of irreversible ...... the RB LXCXE-binding function.
@en
prefLabel
Establishment of irreversible ...... the RB LXCXE-binding function.
@ast
Establishment of irreversible ...... the RB LXCXE-binding function.
@en
P2860
P1476
Establishment of irreversible ...... the RB LXCXE-binding function.
@en
P2093
P2860
P304
P356
10.1128/MCB.20.15.5571-5580.2000
P407
P577
2000-08-01T00:00:00Z