The multisubstrate adapter Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signaling for cell survival and DNA repair
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GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2Hepatocyte growth factor and c-Met promote dendritic maturation during hippocampal neuron differentiation via the Akt pathwayPHA665752, a small-molecule inhibitor of c-Met, inhibits hepatocyte growth factor-stimulated migration and proliferation of c-Met-positive neuroblastoma cellsmiR-130a targets MET and induces TRAIL-sensitivity in NSCLC by downregulating miR-221 and 222Crosstalk between nuclear MET and SOX9/β-catenin correlates with castration-resistant prostate cancerThe Molecular Crosstalk between the MET Receptor Tyrosine Kinase and the DNA Damage Response-Biological and Clinical AspectsPossible association between stem-like hallmark and radioresistance in human cervical carcinoma cells.C-Met inhibitor MK-8003 radiosensitizes c-Met-expressing non-small-cell lung cancer cells with radiation-induced c-Met-expressionMolecular and genetic properties of tumors associated with local immune cytolytic activity.The shadow of death on the MET tyrosine kinase receptor.Role of Src signal transduction pathways in scatter factor-mediated cellular protection.Effect of PF-02341066 and radiation on non-small cell lung cancer cells.Hepatocyte growth factor in lung repair and pulmonary fibrosis.Novel therapeutic strategies for acute lung injury induced by lung damaging agents: the potential role of growth factors as treatment options.MET receptor tyrosine kinase as an autism genetic risk factor.The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cellsOncogenic pathways impinging on the G2-restriction point.Inhibition of c-Met as a therapeutic strategy for esophageal adenocarcinoma.Role of Gab1 in UV-induced c-Jun NH2-terminal kinase activation and cell apoptosis.Suppression of adriamycin-induced apoptosis by sustained activation of the phosphatidylinositol-3'-OH kinase-Akt pathway.ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase.Combined EGFR/MET or EGFR/HSP90 inhibition is effective in the treatment of lung cancers codriven by mutant EGFR containing T790M and MET.Anti-apoptotic role of caspase-cleaved GAB1 adaptor protein in hepatocyte growth factor/scatter factor-MET receptor protein signaling.Hepatocyte growth factor/scatter factor blocks the mitochondrial pathway of apoptosis signaling in breast cancer cells.The PI3K-Akt mediates oncogenic Met-induced centrosome amplification and chromosome instability.Inhibition of hypoxia/reoxygenation-induced oxidative stress in HGF-stimulated antiapoptotic signaling: role of PI3-K and Akt kinase upon rac1.Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor.Dihydroartemisinin is an inhibitor of ovarian cancer cell growth.The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma.c-Met and Other Cell Surface Molecules: Interaction, Activation and Functional Consequences.Scatter factor mitigates HIV-1 gp120-induced human mesangial cell injury.Monoclonal Antibodies against the MET/HGF Receptor and Its Ligand: Multitask Tools with Applications from Basic Research to Therapy.Effect of Akt inhibition on scatter factor-regulated gene expression in DU-145 human prostate cancer cells.Protein-protein interactions reveal key canonical pathways, upstream regulators, interactome domains, and novel targets in ALSThe Role of PI3K in Met Driven Cancer: A RecapEnhancing the Radiation Response in KRAS Mutant Colorectal Cancers Using the c-Met Inhibitor Crizotinib
P2860
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P2860
The multisubstrate adapter Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signaling for cell survival and DNA repair
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
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2001年学术文章
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2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
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2001年学术文章
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2001年學術文章
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name
The multisubstrate adapter Gab ...... r cell survival and DNA repair
@ast
The multisubstrate adapter Gab ...... r cell survival and DNA repair
@en
type
label
The multisubstrate adapter Gab ...... r cell survival and DNA repair
@ast
The multisubstrate adapter Gab ...... r cell survival and DNA repair
@en
prefLabel
The multisubstrate adapter Gab ...... r cell survival and DNA repair
@ast
The multisubstrate adapter Gab ...... r cell survival and DNA repair
@en
P2093
P2860
P1476
The multisubstrate adapter Gab ...... r cell survival and DNA repair
@en
P2093
I D Goldberg
P2860
P304
P356
10.1128/MCB.21.15.4968-4984.2001
P407
P577
2001-08-01T00:00:00Z