Approaches to discovery and characterization of inhibitors of amyloid beta-peptide polymerization.
about
Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases?Neuropharmacological Potential of Gastrodia elata Blume and Its ComponentsFeatures of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinityMolecular Mechanism of Thioflavin-T Binding to the Surface of β-Rich Peptide Self-AssembliesCompounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeuticsA safe, blood-brain barrier permeable triphenylmethane dye inhibits amyloid-β neurotoxicity by generating nontoxic aggregatesDesign and characterization of a membrane permeable N-methyl amino acid-containing peptide that inhibits Abeta1-40 fibrillogenesis.Structural properties of Abeta protofibrils stabilized by a small molecule.Hydrogen exchange studies on Alzheimer's amyloid-beta peptides by mass spectrometry using matrix-assisted laser desorption/ionization and electrospray ionization.Coherent multidimensional vibrational spectroscopy of biomolecules: concepts, simulations, and challenges.Phenolic oxime oligomers inhibit Alzheimer's amyloid fibril formation and disaggregate fibrils in vitro.Quantifying prefibrillar amyloids in vitro by using a "thioflavin-like" spectroscopic method.Quantitative structure-activity relationship analysis of β-amyloid aggregation inhibitors.Substoichiometric inhibition of Abeta(1-40) aggregation by a tandem Abeta(40-1-Gly8-1-40) peptide.A multimeric quinacrine conjugate as a potential inhibitor of Alzheimer's beta-amyloid fibril formation.Monomeric α-synuclein binds Congo Red micelles in a disordered mannerEffects of Various Flavonoids on the α-Synuclein Fibrillation Process.Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins.Amyloid-fibril formation. Proposed mechanisms and relevance to conformational disease.Protein-protein interactions: mechanisms and modification by drugs.A multi-pathway perspective on protein aggregation: implications for control of the rate and extent of amyloid formation.Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic miceSimulation of two-dimensional infrared spectroscopy of amyloid fibrils.L17A/F19A Substitutions Augment the α-Helicity of β-Amyloid Peptide Discordant Segment.Inhibition of amyloid peptide fibrillation by inorganic nanoparticles: functional similarities with proteinsPlasticity of amyloid fibrils.Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils.Tanshinones inhibit amyloid aggregation by amyloid-β peptide, disaggregate amyloid fibrils, and protect cultured cellsEffect of four medicinal plants on amyloid-β induced neurotoxicity in SH-SY5Y cells.Inhibition of Alzheimer's amyloid toxicity with a tricyclic pyrone molecule in vitro and in vivo.1950 MHz radiofrequency electromagnetic fields do not aggravate memory deficits in 5xFAD mice.Pharmacotherapy of agitation and psychotic symptoms in Alzheimer's disease.Inhibition of aggregate formation as therapeutic target in protein misfolding diseases: effect of tetracycline and trehalose.Computational insights into the development of novel therapeutic strategies for Alzheimer's disease.A survey of peptides with effective therapeutic potential in Alzheimer's disease rodent models or in human clinical studies.Protein fibrillation and nanoparticle interactions: opportunities and challenges.Effects of Congo red on aβ(1-40) fibril formation process and morphology.Assembly of synthetic Aβ miniamyloids on polyol templates.Structure-activity relationships in peptide modulators of β-amyloid protein aggregation: variation in α,α-disubstitution results in altered aggregate size and morphologyKinetics and energetics of assembly, nucleation, and growth of aggregates and fibrils for an amyloidogenic protein. Insights into transition states from pressure, temperature, and co-solute studies.
P2860
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P2860
Approaches to discovery and characterization of inhibitors of amyloid beta-peptide polymerization.
description
2000 nî lūn-bûn
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2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Approaches to discovery and ch ...... d beta-peptide polymerization.
@ast
Approaches to discovery and ch ...... d beta-peptide polymerization.
@en
type
label
Approaches to discovery and ch ...... d beta-peptide polymerization.
@ast
Approaches to discovery and ch ...... d beta-peptide polymerization.
@en
prefLabel
Approaches to discovery and ch ...... d beta-peptide polymerization.
@ast
Approaches to discovery and ch ...... d beta-peptide polymerization.
@en
P1476
Approaches to discovery and ch ...... d beta-peptide polymerization.
@en
P2093
M A Findeis
P356
10.1016/S0925-4439(00)00034-X
P407
P577
2000-07-01T00:00:00Z