Inhibition of Alzheimer's amyloid toxicity with a tricyclic pyrone molecule in vitro and in vivo.
about
Dye-binding assays for evaluation of the effects of small molecule inhibitors on amyloid (aβ) self-assemblySelective and Irreversible Inhibitors of Mosquito Acetylcholinesterases for Controlling Malaria and Other Mosquito-Borne DiseasesModulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanismsAlzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficitsModification of a small β-barrel protein, to give pseudo-amyloid structures, inhibits amyloid β-peptide aggregation.Tricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons.Syntheses, neural protective activities, and inhibition of glycogen synthase kinase-3β of substituted quinolines.The influence of spin-labeled fluorene compounds on the assembly and toxicity of the aβ peptide.Effect of Alpinia zerumbet components on antioxidant and skin diseases-related enzymesInhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloid β (Aβ) oligomers-induced neuronal cell death by tricyclic pyrone moleculesDesign, synthesis, and evaluation of bioactive small molecules.Protective effects of curcumin in APPswe transfected SH-SY5Y cellsModulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's DiseaseInhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex ProbesProtective spin-labeled fluorenes maintain amyloid beta peptide in small oligomers and limit transitions in secondary structure.Vitamin D-binding protein interacts with Aβ and suppresses Aβ-mediated pathology.Methods for structural characterization of prefibrillar intermediates and amyloid fibrils.Treatment strategies targeting amyloid β-protein.Rationally designed peptidomimetic modulators of aβ toxicity in Alzheimer's disease.Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein.The Anti-Amyloid-β and Neuroprotective Properties of a Novel Tricyclic Pyrone Molecule.Polyphenolic glycosides and aglycones utilize opposing pathways to selectively remodel and inactivate toxic oligomers of amyloid β.Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept.Ayurvedic Medicine for the Treatment of Dementia: Mechanistic Aspects.
P2860
Q26852205-7627ED40-F156-4CF5-BC98-ACA51487945FQ27657210-AD647133-CFC1-4BBF-A490-6035751CC251Q28259424-3E9EA56B-6A6A-4F4A-B235-0884CFE31965Q28544876-D60D9F39-161C-44B0-8CDE-248BFA0BBD43Q30155139-64BEE0E9-5419-4F9E-81BD-3F513FBE400CQ33479778-4E443801-E469-42F2-9AB5-5DBAFD4467A4Q33949740-1294A2CD-3925-4762-8FE9-B0AEAABB38EAQ34256411-088E6B8F-64B3-46A0-BF32-F4CE87FEF06EQ34350094-AB7FC104-177D-4C64-BCC6-A302907D645AQ34425690-A05FC7E4-1930-4195-AC4E-78D028A2B174Q34529255-285ED9C8-5948-447F-842C-D4FB00EE5E0AQ35148858-C4FC6D47-B4A6-4FCB-A9B4-458BE4F83E4BQ35733751-553C6498-0A91-41C7-B4E2-2D0BE48D1CF1Q36106553-F7390290-B4DB-4D3F-AAC1-E232EA1FF310Q36244824-D9F86A1F-752A-4122-A9DC-8AAB164DDACEQ36678341-D060E88D-072E-48FC-A1B0-7A02979A9C07Q37501266-473DD6B7-B98E-40C2-9F29-4DA4E649E2B5Q38040990-6FDBAD19-1B30-47F3-86E8-B9E203697F96Q42040453-0D72AAFF-4C8D-4B4F-A38E-87ED17BB474DQ42214633-C444B6FD-33F1-4EA3-A98E-25CCFC45B974Q42254678-183184FC-A71A-4B68-9607-B1EEDAFB7538Q42843362-4C31052C-77B1-4311-86EA-43DC9E2EDAEFQ47258976-173981A4-6F37-4A5A-8A36-5CD700D6E255Q55281800-6F78E3B8-46E9-47D1-BAEB-CF8F709CD0F5
P2860
Inhibition of Alzheimer's amyloid toxicity with a tricyclic pyrone molecule in vitro and in vivo.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Inhibition of Alzheimer's amyl ...... molecule in vitro and in vivo.
@en
Inhibition of Alzheimer's amyl ...... molecule in vitro and in vivo.
@nl
type
label
Inhibition of Alzheimer's amyl ...... molecule in vitro and in vivo.
@en
Inhibition of Alzheimer's amyl ...... molecule in vitro and in vivo.
@nl
prefLabel
Inhibition of Alzheimer's amyl ...... molecule in vitro and in vivo.
@en
Inhibition of Alzheimer's amyl ...... molecule in vitro and in vivo.
@nl
P2093
P2860
P1476
Inhibition of Alzheimer's amyl ...... molecule in vitro and in vivo.
@en
P2093
Feimeng Zhou
Hyun-Seok Hong
Lee-Way Jin
Lydia Barrigan
Sandeep Rana
P2860
P304
P356
10.1111/J.1471-4159.2008.05866.X
P407
P577
2009-02-01T00:00:00Z