Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists.
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The CB2-preferring agonist JWH015 also potently and efficaciously activates CB1 in autaptic hippocampal neuronsBeyond THC: The New Generation of Cannabinoid Designer DrugsIn vitro and in vivo characterization of A-796260: a selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain modelsTargeting the cannabinoid CB2 receptor: modelling and structural determinants of CB2 selective ligandsEmerging drugs of abuse: current perspectives on synthetic cannabinoidsTargeting cannabinoid agonists for inflammatory and neuropathic painDesign, synthesis, and biological evaluation of aminoalkylindole derivatives as cannabinoid receptor ligands with potential for treatment of alcohol abuse.Adverse effects after the use of JWH-210 - a case series from the EU Spice II plus project.Synthetic Cannabinoid-Induced Immunosuppression Augments Cerebellar Dysfunction in Tetanus-Toxin Treated Mice.Evaluation of a homogenous enzyme immunoassay for the detection of synthetic cannabinoids in urineIdentification of ten new designer drugs by GC-MS, UPLC-QTOF-MS, and NMR as part of a police investigation of a Danish internet company.JWH-018 in rhesus monkeys: differential antagonism of discriminative stimulus, rate-decreasing, and hypothermic effects.Cross-substitution of Δ9-tetrahydrocannabinol and JWH-018 in drug discrimination in rats.8-Chloro- and 5,8-Dichloro1-naphthoic Acids.1-Pentyl-3-phenylacetylindoles and JWH-018 share in vivo cannabinoid profiles in mice1-Bromo-3-(1',1'-dimethylalkyl)-1-deoxy-Δ(8)-tetrahydrocannabinols: New selective ligands for the cannabinoid CB(2) receptor.A high-sensitivity ultra-high performance liquid chromatography/high-resolution time-of-flight mass spectrometry (UHPLC-HR-TOFMS) method for screening synthetic cannabinoids and other drugs of abuse in urine.Moving around the molecule: relationship between chemical structure and in vivo activity of synthetic cannabinoids.Baths salts, spice, and related designer drugs: the science behind the headlines.High-resolution mass spectrometric determination of the synthetic cannabinoids MAM-2201, AM-2201, AM-2232, and their metabolites in postmortem plasma and urine by LC/Q-TOFMS.Detection and Characterization of the Effect of AB-FUBINACA and Its Metabolites in a Rat ModelCB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides.Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice.Cannabinoids inhibit cholinergic contraction in human airways through prejunctional CB1 receptors.Synthetic cannabinoids: epidemiology, pharmacodynamics, and clinical implications.Δ(9)-Tetrahydrocannabinol-like effects of novel synthetic cannabinoids in mice and ratsJWH-018 and JWH-073: Δ⁹-tetrahydrocannabinol-like discriminative stimulus effects in monkeysMonohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity.Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: steric and electronic effects of 4- and 8-halogenated naphthoyl substituentsPurity of synthetic cannabinoids sold online for recreational useThe antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors.Cannabinoid 2 receptor- and beta Arrestin 2-dependent upregulation of serotonin 2A receptors.New anti-inflammatory agents to reduce atherosclerosis.Cannabinoid agonists increase the interaction between β-Arrestin 2 and ERK1/2 and upregulate β-Arrestin 2 and 5-HT(2A) receptors.Acylation of N-p-Toluenesulfonylpyrrole Under Friedel-Crafts Conditions. Evidence for Organoaluminum IntermediatesGas chromatography-mass spectrometry of JWH-018 metabolites in urine samples with direct comparison to analytical standardsThe Directive 2010/63/EU on animal experimentation may skew the conclusions of pharmacological and behavioural studies.Spicing things up: synthetic cannabinoids.Cannabinoids inhibit T-cells via cannabinoid receptor 2 in an in vitro assay for graft rejection, the mixed lymphocyte reaction.Cannabinoids in disguise: Δ9-tetrahydrocannabinol-like effects of tetramethylcyclopropyl ketone indoles.
P2860
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P2860
Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Structure-activity relationshi ...... ctive CB(2) receptor agonists.
@ast
Structure-activity relationshi ...... ctive CB(2) receptor agonists.
@en
type
label
Structure-activity relationshi ...... ctive CB(2) receptor agonists.
@ast
Structure-activity relationshi ...... ctive CB(2) receptor agonists.
@en
prefLabel
Structure-activity relationshi ...... ctive CB(2) receptor agonists.
@ast
Structure-activity relationshi ...... ctive CB(2) receptor agonists.
@en
P2093
P921
P1476
Structure-activity relationshi ...... ctive CB(2) receptor agonists.
@en
P2093
Alicia L S Thompson
Cindy Tartal
Dana E Selley
Dow P Hurst
George Hynd
Gulay Zengin
Jenny L Wiley
Jianzhong Lu
Kristen Bushell
Michael P Cassidy
P304
P356
10.1016/J.BMC.2004.09.050
P407
P577
2005-01-01T00:00:00Z