Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists. - Wikidata - awgldk - TriplyDB

Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists.

Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists.

http://www.wikidata.org/entity/Q33983584

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The CB2-preferring agonist JWH015 also potently and efficaciously activates CB1 in autaptic hippocampal neurons Beyond THC: The New Generation of Cannabinoid Designer Drugs In vitro and in vivo characterization of A-796260: a selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models Targeting the cannabinoid CB2 receptor: modelling and structural determinants of CB2 selective ligands Emerging drugs of abuse: current perspectives on synthetic cannabinoids Targeting cannabinoid agonists for inflammatory and neuropathic pain Design, synthesis, and biological evaluation of aminoalkylindole derivatives as cannabinoid receptor ligands with potential for treatment of alcohol abuse.Adverse effects after the use of JWH-210 - a case series from the EU Spice II plus project.Synthetic Cannabinoid-Induced Immunosuppression Augments Cerebellar Dysfunction in Tetanus-Toxin Treated Mice.Evaluation of a homogenous enzyme immunoassay for the detection of synthetic cannabinoids in urine Identification of ten new designer drugs by GC-MS, UPLC-QTOF-MS, and NMR as part of a police investigation of a Danish internet company.JWH-018 in rhesus monkeys: differential antagonism of discriminative stimulus, rate-decreasing, and hypothermic effects.Cross-substitution of Δ9-tetrahydrocannabinol and JWH-018 in drug discrimination in rats.8-Chloro- and 5,8-Dichloro1-naphthoic Acids.1-Pentyl-3-phenylacetylindoles and JWH-018 share in vivo cannabinoid profiles in mice 1-Bromo-3-(1',1'-dimethylalkyl)-1-deoxy-Δ(8)-tetrahydrocannabinols: New selective ligands for the cannabinoid CB(2) receptor.A high-sensitivity ultra-high performance liquid chromatography/high-resolution time-of-flight mass spectrometry (UHPLC-HR-TOFMS) method for screening synthetic cannabinoids and other drugs of abuse in urine.Moving around the molecule: relationship between chemical structure and in vivo activity of synthetic cannabinoids.Baths salts, spice, and related designer drugs: the science behind the headlines.High-resolution mass spectrometric determination of the synthetic cannabinoids MAM-2201, AM-2201, AM-2232, and their metabolites in postmortem plasma and urine by LC/Q-TOFMS.Detection and Characterization of the Effect of AB-FUBINACA and Its Metabolites in a Rat Model CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides.Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice.Cannabinoids inhibit cholinergic contraction in human airways through prejunctional CB1 receptors.Synthetic cannabinoids: epidemiology, pharmacodynamics, and clinical implications.Δ(9)-Tetrahydrocannabinol-like effects of novel synthetic cannabinoids in mice and rats JWH-018 and JWH-073: Δ⁹-tetrahydrocannabinol-like discriminative stimulus effects in monkeys Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity.Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: steric and electronic effects of 4- and 8-halogenated naphthoyl substituents Purity of synthetic cannabinoids sold online for recreational use The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors.Cannabinoid 2 receptor- and beta Arrestin 2-dependent upregulation of serotonin 2A receptors.New anti-inflammatory agents to reduce atherosclerosis.Cannabinoid agonists increase the interaction between β-Arrestin 2 and ERK1/2 and upregulate β-Arrestin 2 and 5-HT(2A) receptors.Acylation of N-p-Toluenesulfonylpyrrole Under Friedel-Crafts Conditions. Evidence for Organoaluminum Intermediates Gas chromatography-mass spectrometry of JWH-018 metabolites in urine samples with direct comparison to analytical standards The Directive 2010/63/EU on animal experimentation may skew the conclusions of pharmacological and behavioural studies.Spicing things up: synthetic cannabinoids.Cannabinoids inhibit T-cells via cannabinoid receptor 2 in an in vitro assay for graft rejection, the mixed lymphocyte reaction.Cannabinoids in disguise: Δ9-tetrahydrocannabinol-like effects of tetramethylcyclopropyl ketone indoles.

P2860

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P2860

Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists.

http://www.wikidata.org/entity/Q33983584

description

2005 nî lūn-bûn

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2005 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2005 թվականի հունվարին հրատարակված գիտական հոդված

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2005年の論文

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Structure-activity relationshi ...... ctive CB(2) receptor agonists.

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Structure-activity relationshi ...... ctive CB(2) receptor agonists.

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J.BMC.2004.09.050

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Bioorganic & Medicinal Chemistry

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Alicia L S Thompson

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Cindy Tartal

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Dana E Selley

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Dow P Hurst

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Michael P Cassidy

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89-112

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10.1016/J.BMC.2004.09.050

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1

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13

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John W. Huffman

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2005-01-01T00:00:00Z

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8146351

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