Antagonistic VEGF variants engineered to simultaneously bind to and inhibit VEGFR2 and alphavbeta3 integrin
about
Development of a highly-potent anti-angiogenic VEGF8-109 heterodimer by directed blocking of its VEGFR-2 binding siteEndorepellin laminin-like globular 1/2 domains bind Ig3-5 of vascular endothelial growth factor (VEGF) receptor 2 and block pro-angiogenic signaling by VEGFA in endothelial cellsAn engineered transforming growth factor β (TGF-β) monomer that functions as a dominant negative to block TGF-β signalingDesign and applications of bispecific heterodimers: molecular imaging and beyondUtilizing combinatorial engineering to develop Tie2 targeting antagonistic angiopoetin-2 ligands as candidates for anti-angiogenesis therapyEpitope-guided engineering of monobody binders for in vivo inhibition of Erk-2 signaling.Simultaneous targeting of two ligand-binding sites on VEGFR2 using biparatopic Affibody molecules results in dramatically improved affinity.Induction of Angiogenesis by Matrigel Coating of VEGF-Loaded PEG/PCL-Based Hydrogel Scaffolds for hBMSC Transplantation.Synthesis, Characterization, and Biological Evaluation of a Dual-Action Ligand Targeting αvβ3 Integrin and VEGF ReceptorsEndorepellin affects angiogenesis by antagonizing diverse vascular endothelial growth factor receptor 2 (VEGFR2)-evoked signaling pathways: transcriptional repression of hypoxia-inducible factor 1α and VEGFA and concurrent inhibition of nuclear factCell Adhesion on RGD-Displaying Knottins with Varying Numbers of Tryptophan Amino Acids to Tune the Affinity for Assembly on Cucurbit[8]uril Surfaces.Specific VEGF sequestering to biomaterials: influence of serum stability.Effects of a novel cyclic RGD peptidomimetic on cell proliferation, migration and angiogenic activity in human endothelial cellsA computational combinatorial approach identifies a protein inhibitor of superoxide dismutase 1 misfolding, aggregation, and cytotoxicity.Enhanced VEGF signalling mediates cerebral neovascularisation via downregulation of guidance protein ROBO4 in a rat model of diabetes.Astrocytes spatially restrict VEGF signaling by polarized secretion and incorporation of VEGF into the actively assembling extracellular matrix.Engineered ligand-based VEGFR antagonists with increased receptor binding affinity more effectively inhibit angiogenesis.Targeting the vasculature of colorectal carcinoma with a fused protein of (RGD)₃-tTF.A bi-specific inhibitor targeting IL-17A and MMP-9 reduces invasion and motility in MDA-MB-231 cells.Targeting the MMP-14/MMP-2/integrin αβ axis with multispecific N-TIMP2-based antagonists for cancer therapyTargeting the Tie2-αβ integrin axis with bi-specific reagents for the inhibition of angiogenesis
P2860
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P2860
Antagonistic VEGF variants engineered to simultaneously bind to and inhibit VEGFR2 and alphavbeta3 integrin
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Antagonistic VEGF variants eng ...... EGFR2 and alphavbeta3 integrin
@ast
Antagonistic VEGF variants eng ...... EGFR2 and alphavbeta3 integrin
@en
type
label
Antagonistic VEGF variants eng ...... EGFR2 and alphavbeta3 integrin
@ast
Antagonistic VEGF variants eng ...... EGFR2 and alphavbeta3 integrin
@en
prefLabel
Antagonistic VEGF variants eng ...... EGFR2 and alphavbeta3 integrin
@ast
Antagonistic VEGF variants eng ...... EGFR2 and alphavbeta3 integrin
@en
P2093
P2860
P356
P1476
Antagonistic VEGF variants eng ...... EGFR2 and alphavbeta3 integrin
@en
P2093
Adam P Silverman
Jennifer L Lahti
Jennifer R Cochran
P2860
P304
14067-14072
P356
10.1073/PNAS.1016635108
P407
P577
2011-08-08T00:00:00Z