Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1.
about
The dynamic cilium in human diseasesNephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammalsExperimental therapies and ongoing clinical trials to slow down progression of ADPKDThe role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologiesThe exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypesA genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formationPPAR-gamma agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney diseaseLoss of oriented cell division does not initiate cyst formationRSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells.Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models.Advances in the pathogenesis and treatment of polycystic kidney diseaseMolecular advances in autosomal dominant polycystic kidney disease.Abnormalities in focal adhesion complex formation, regulation, and function in human autosomal recessive polycystic kidney disease epithelial cellsNovel targets for the treatment of autosomal dominant polycystic kidney disease.Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease.Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney diseaseIntratubular hydrodynamic forces influence tubulointerstitial fibrosis in the kidney.Kidney-specific inactivation of Ofd1 leads to renal cystic disease associated with upregulation of the mTOR pathwayThe cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation.Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKDRosiglitazone inhibits transforming growth factor-β1 mediated fibrogenesis in ADPKD cyst-lining epithelial cells.Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease.ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice.Mechanotransduction in the renal tubuleHDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells.Exploring the genetic basis of early-onset chronic kidney disease.Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis.Cyclic AMP-mediated cyst expansionEctopic expression of Cux1 is associated with reduced p27 expression and increased apoptosis during late stage cyst progression upon inactivation of Pkd1 in collecting ducts.Cilia movement regulates expression of the Raf-1 kinase inhibitor proteinThe small GTPase Cdc42 is necessary for primary ciliogenesis in renal tubular epithelial cells.Altered trafficking and stability of polycystins underlie polycystic kidney disease.c-Src inactivation reduces renal epithelial cell-matrix adhesion, proliferation, and cyst formationInactivation of integrin-β1 prevents the development of polycystic kidney disease after the loss of polycystin-1.Aquaporin-1 retards renal cyst development in polycystic kidney disease by inhibition of Wnt signaling.Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease.Scattered Deletion of PKD1 in Kidneys Causes a Cystic Snowball Effect and Recapitulates Polycystic Kidney DiseaseGlycogen synthase kinase-3β promotes cyst expansion in polycystic kidney diseasePolycystin-1 Is a Cardiomyocyte Mechanosensor That Governs L-Type Ca2+ Channel Protein Stability
P2860
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P2860
Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1.
description
2008 nî lūn-bûn
@nan
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Cyst formation and activation ...... specific inactivation of Pkd1.
@ast
Cyst formation and activation ...... specific inactivation of Pkd1.
@en
type
label
Cyst formation and activation ...... specific inactivation of Pkd1.
@ast
Cyst formation and activation ...... specific inactivation of Pkd1.
@en
prefLabel
Cyst formation and activation ...... specific inactivation of Pkd1.
@ast
Cyst formation and activation ...... specific inactivation of Pkd1.
@en
P2093
P2860
P356
P1476
Cyst formation and activation ...... specific inactivation of Pkd1
@en
P2093
Angeliki Louvi
Heino Velazquez
Lloyd G Cantley
Michihiro Mitobe
R Brent Thomson
Saori Nishio
Sekiya Shibazaki
Shuta Ishibe
Stefan Somlo
P2860
P304
P356
10.1093/HMG/DDN039
P577
2008-02-07T00:00:00Z