The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity - Wikidata - awgldk - TriplyDB

The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity

The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity

http://www.wikidata.org/entity/Q33986439

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Mitochondrial Stat3, the Need for Design Thinking Phytochemicals for the Management of Melanoma Perspectives on new synthetic curcumin analogs and their potential anticancer properties Tagging of genomic STAT3 and STAT1 with fluorescent proteins and insertion of a luciferase reporter in the cyclin D1 gene provides a modified A549 cell line to screen for selective STAT3 inhibitors Signal transducer and activator of transcription 3 in myeloid-derived suppressor cells: an opportunity for cancer therapy Myeloid derived suppressor cells-An overview of combat strategies to increase immunotherapy efficacy Identification of STAT1 and STAT3 specific inhibitors using comparative virtual screening and docking validation PIAS3 expression in squamous cell lung cancer is low and predicts overall survival.Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines.Role of STAT3 in cancer metastasis and translational advances.STAT3 Inhibition as a Therapeutic Strategy for Chordoma.Discovery of monocarbonyl curcumin-BTP hybrids as STAT3 inhibitors for drug-sensitive and drug-resistant breast cancer therapy.Myeloid derived suppressor cells - a new therapeutic target in the treatment of cancer.Tumor-induced STAT3 signaling in myeloid cells impairs dendritic cell generation by decreasing PKCβII abundance Curcumin activates the p38MPAK-HSP25 pathway in vitro but fails to attenuate diabetic nephropathy in DBA2J mice despite urinary clearance documented by HPLC The curcumin analog DM-1 induces apoptotic cell death in melanoma.Targeting constitutively-activated STAT3 in hypoxic ovarian cancer, using a novel STAT3 inhibitor The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines Characterization of the host-guest complex of a curcumin analog with β-cyclodextrin and β-cyclodextrin-gemini surfactant and evaluation of its anticancer activity.PRMT5 is upregulated in malignant and metastatic melanoma and regulates expression of MITF and p27(Kip1.).Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy.Curcumin: a novel Stat3 pathway inhibitor for chemoprevention of lung cancer Erdr1 Suppresses Murine Melanoma Growth via Regulation of Apoptosis.First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy.New perspectives of curcumin in cancer prevention.Overcoming chemo/radio-resistance of pancreatic cancer by inhibiting STAT3 signaling.Human cytomegalovirus IE1 protein disrupts interleukin-6 signaling by sequestering STAT3 in the nucleus.The impact of curcumin on breast cancer.Targeting Tregs in Malignant Brain Cancer: Overcoming IDO.Curcuma Contra Cancer? Curcumin and Hodgkin's Lymphoma.Curcumin and omega-3 fatty acids enhance NK cell-induced apoptosis of pancreatic cancer cells but curcumin inhibits interferon-γ production: benefits of omega-3 with curcumin against cancer.Curcumin: A new candidate for melanoma therapy?Myeloid-derived suppressor cells as effectors of immune suppression in cancer.Modulation of apoptosis-related cell signalling pathways by curcumin as a strategy to inhibit tumor progression.STAT3 targeting by polyphenols: Novel therapeutic strategy for melanoma.Hypoxia and STAT3 signalling interactions regulate pro-inflammatory pathways in rheumatoid arthritis.Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor.Unleashing the immune response against childhood solid cancers.Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells.The potential for targeting the STAT3 pathway as a novel therapy for melanoma.

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P2860

The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity

http://www.wikidata.org/entity/Q33986439

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2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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Molecular Cancer

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Chenglong Li

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Courtney Bakan

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Dale G Hoyt

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Gregory B Lesinski

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James R Fuchs

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Jennifer Yui

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Jiayuh Lin

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P2860

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

Evaluating the cytotoxicity of innate immune effector cells using the GrB ELISPOT assay

Interferons, immunity and cancer immunoediting

Stat3 as an oncogene

A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.

Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells

Roles of STAT3 defined by tissue-specific gene targeting.

Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.

Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.

Inhibition of p-STAT3 enhances IFN-alpha efficacy against metastatic melanoma in a murine model.

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Dalia S Abdelhamid

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