Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2 - Wikidata - awgldk - TriplyDB

Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

http://www.wikidata.org/entity/Q33996300

about

Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR Detection of a novel unglycosylated form of hepatitis C virus E2 envelope protein that is located in the cytosol and interacts with PKR Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress Interaction of human tRNA-dihydrouridine synthase-2 with interferon-induced protein kinase PKR Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control A new double-stranded RNA-binding protein that interacts with PKR The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR Inhibition of PACT-mediated activation of PKR by the herpes simplex virus type 1 Us11 protein.A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha Molecular basis for PKR activation by PACT or dsRNA Modular structure of PACT: distinct domains for binding and activating PKR Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation West Nile Virus-Induced Interferon Production Is Mediated by the Double-Stranded RNA-Dependent Protein Kinase PKR Interferon-inducible antiviral effectors YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed.Dimerization by translation initiation factor 2 kinase GCN2 is mediated by interactions in the C-terminal ribosome-binding region and the protein kinase domain.Phosphorylation of initiation factor eIF2 in response to stress conditions is mediated by acidic ribosomal P1/P2 proteins in Saccharomyces cerevisiae.Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells.Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC Phosphorylation of specific serine residues in the PKR activation domain of PACT is essential for its ability to mediate apoptosis RNA-binding proteins: modular design for efficient function Two heme-binding domains of heme-regulated eukaryotic initiation factor-2alpha kinase. N terminus and kinase insertion Activation of double-stranded RNA-activated protein kinase by mild impairment of oxidative metabolism in neurons Autophosphorylation of heme-regulated eukaryotic initiation factor 2α kinase and the role of the modification in catalysis IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth PfeIK1, a eukaryotic initiation factor 2alpha kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation Characterization of phosphopeptides from protein digests using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and nanoelectrospray quadrupole time-of-flight mass spectrometry.Functional characterization of and cooperation between the double-stranded RNA-binding motifs of the protein kinase PKR.Characterization of the hemin-sensitive eukaryotic initiation factor 2alpha kinase from mouse nonerythroid cells.Interaction of double-stranded RNA-dependent protein kinase (PKR) with the death receptor signaling pathway in amyloid beta (Abeta)-treated cells and in APPSLPS1 knock-in mice Enhanced interaction between pseudokinase and kinase domains in Gcn2 stimulates eIF2α phosphorylation in starved cells The 3'-untranslated regions of cytoskeletal muscle mRNAs inhibit translation by activating the double-stranded RNA-dependent protein kinase PKR.Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy Decreased ATF4 expression as a mechanism of acquired resistance to long-term amino acid limitation in cancer cells Mechanism of interferon action: identification of essential positions within the novel 15-base-pair KCS element required for transcriptional activation of the RNA-dependent protein kinase pkr gene Diversity in viral anti-PKR mechanisms: a remarkable case of evolutionary convergence Hepatitis C virus envelope protein E2 does not inhibit PKR by simple competition with autophosphorylation sites in the RNA-binding domain.

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P2860

Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

http://www.wikidata.org/entity/Q33996300

description

1998 nî lūn-bûn

@nan

1998 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

1998年の論文

@ja

1998年論文

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1998年論文

@zh-hant

1998年論文

@zh-hk

1998年論文

@zh-mo

1998年論文

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1998年论文

@wuu

name

Autophosphorylation in the act ...... or 2alpha kinases PKR and GCN2

@ast

Autophosphorylation in the act ...... or 2alpha kinases PKR and GCN2

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type

label

Autophosphorylation in the act ...... or 2alpha kinases PKR and GCN2

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Autophosphorylation in the act ...... or 2alpha kinases PKR and GCN2

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Autophosphorylation in the act ...... or 2alpha kinases PKR and GCN2

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Autophosphorylation in the act ...... or 2alpha kinases PKR and GCN2

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Molecular and Cellular Biology

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Autophosphorylation in the act ...... or 2alpha kinases PKR and GCN2

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P2093

A G Hinnebusch

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C Herring

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D R Taylor

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F Zhang

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J Qin

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M B Mathews

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M T Garcia-Barrio

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P R Romano

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Q Wang

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X Zhang

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P2860

Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase

Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast

Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo

Autophosphorylation sites participate in the activation of the double-stranded-RNA-activated protein kinase PKR

The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

Atomic structure of the MAP kinase ERK2 at 2.3 A resolution

Activation mechanism of the MAP kinase ERK2 by dual phosphorylation

Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

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2282-2297

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scholarly article

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10.1128/MCB.18.4.2282

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P433

4

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18

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1998-04-01T00:00:00Z

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9528799

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121479

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