Impaired vascular contractility and aortic wall degeneration in fibulin-4 deficient mice: effect of angiotensin II type 1 (AT1) receptor blockade. - Wikidata - awgldk - TriplyDB

Impaired vascular contractility and aortic wall degeneration in fibulin-4 deficient mice: effect of angiotensin II type 1 (AT1) receptor blockade.

Impaired vascular contractility and aortic wall degeneration in fibulin-4 deficient mice: effect of angiotensin II type 1 (AT1) receptor blockade.

http://www.wikidata.org/entity/Q33999588

about

Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries.Fibulin-4 and fibulin-5 in elastogenesis and beyond: Insights from mouse and human studies.Smooth muscle LDL receptor-related protein-1 deletion induces aortic insufficiency and promotes vascular cardiomyopathy in mice Matrix metalloproteinases promote arterial remodeling in aging, hypertension, and atherosclerosis Role of mechanotransduction in vascular biology: focus on thoracic aortic aneurysms and dissections.Differences in genetic signaling, and not mechanical properties of the wall, are linked to ascending aortic aneurysms in fibulin-4 knockout mice Matrix-dependent perturbation of TGFβ signaling and disease Fibulin-4 deficiency increases TGF-β signalling in aortic smooth muscle cells due to elevated TGF-β2 levels.The Beneficial Effect of Renin-Angiotensin-Aldosterone System Blockade in Marfan Syndrome Patients after Aortic Root Replacement.Conundrum of angiotensin II and TGF-β interactions in aortic aneurysms Defective Connective Tissue Remodeling in Smad3 Mice Leads to Accelerated Aneurysmal Growth Through Disturbed Downstream TGF-β Signaling Angiotensin-converting enzyme-induced activation of local angiotensin signaling is required for ascending aortic aneurysms in fibulin-4-deficient mice.Involvement of the renin-angiotensin system in abdominal and thoracic aortic aneurysms.Myofibroblast-mediated mechanisms of pathological remodelling of the heart.Function of Ltbp-4L and fibulin-4 in survival and elastogenesis in mice.Therapeutics Targeting Drivers of Thoracic Aortic Aneurysms and Acute Aortic Dissections: Insights from Predisposing Genes and Mouse Models.Angiotensin II induces region-specific medial disruption during evolution of ascending aortic aneurysms Molecular mechanisms of inherited thoracic aortic disease - from gene variant to surgical aneurysm.MMP17/MT4-MMP and thoracic aortic aneurysms: OPNing new potential for effective treatment.Extracellular Interactions between Fibulins and Transforming Growth Factor (TGF)-β in Physiological and Pathological Conditions

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Impaired vascular contractility and aortic wall degeneration in fibulin-4 deficient mice: effect of angiotensin II type 1 (AT1) receptor blockade.

http://www.wikidata.org/entity/Q33999588

description

2011 nî lūn-bûn

@nan

2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի օգոստոսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Impaired vascular contractilit ...... ype 1 (AT1) receptor blockade.

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Impaired vascular contractilit ...... ype 1 (AT1) receptor blockade.

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Impaired vascular contractilit ...... ype 1 (AT1) receptor blockade.

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Impaired vascular contractilit ...... ype 1 (AT1) receptor blockade.

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Impaired vascular contractilit ...... ype 1 (AT1) receptor blockade.

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JOURNAL.PONE.0023411

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Impaired vascular contractilit ...... ype 1 (AT1) receptor blockade.

@en

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A H Jan Danser

http://www.w3.org/2001/XMLSchema#string

Angelique M Bouhuizen

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Dirk J Duncker

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Ellen V Rouwet

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Els Moltzer

http://www.w3.org/2001/XMLSchema#string

Jeroen Essers

http://www.w3.org/2001/XMLSchema#string

Joep H M van Esch

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Luuk te Riet

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Marcel Vermeij

http://www.w3.org/2001/XMLSchema#string

Monique C de Waard

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P2860

Sequence, recombinant expression and tissue localization of two novel extracellular matrix proteins, fibulin-3 and fibulin-4

Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome

Fibulin-4: a novel gene for an autosomal recessive cutis laxa syndrome

Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Angiotensin II blockade and aortic-root dilation in Marfan's syndrome

Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome

Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression

Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice.

The role of the renin-angiotensin system in aortic aneurysmal diseases.

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e23411

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10.1371/JOURNAL.PONE.0023411

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