Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.
about
ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stressThe E3 ligase Smurf1 regulates Wolfram syndrome protein stability at the endoplasmic reticulumCKIP-1 couples Smurf1 ubiquitin ligase with Rpt6 subunit of proteasome to promote substrate degradationATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundanceUSP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination.Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradationmicroRNA-365, down-regulated in colon cancer, inhibits cell cycle progression and promotes apoptosis of colon cancer cells by probably targeting Cyclin D1 and Bcl-2.The oncogenic role of microRNA-130a/301a/454 in human colorectal cancer via targeting Smad4 expressionStructural insights into the functional versatility of WW domain-containing oxidoreductase tumor suppressor.Atypical ubiquitin ligase RNF31: the nuclear factor modulator in breast cancer progression.RING finger protein 31 promotes p53 degradation in breast cancer cells.Transcription factor Six2 mediates the protection of GDNF on 6-OHDA lesioned dopaminergic neurons by regulating Smurf1 expression.Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: involvement of the RB-microRNA axis.KRAS protein stability is regulated through SMURF2: UBCH5 complex-mediated β-TrCP1 degradation.Inhibition of Smurf2 translation by miR-322/503 modulates TGF-β/Smad2 signaling and intestinal epithelial homeostasis.A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks.An unconventional role of BMP-Smad1 signaling in DNA damage response: a mechanism for tumor suppression.CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation.Genome profiling of pancreatic adenocarcinoma.Impaired phosphorylation and ubiquitination by p70 S6 kinase (p70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promote tribbles homolog 2 (TRIB2) stability and carcinogenic property in liver cancer.Regionally different immunoreactivity for Smurf2 and pSmad2/3 in TDP-43-positive inclusions of amyotrophic lateral sclerosis.The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis.E3 ubiquitin ligases in cancer and implications for therapies.Suppression of the Smurf1 Expression Inhibits Tumor Progression in Gliomas.MicroRNA-378 regulates cell proliferation and migration by repressing RNF31 in pituitary adenoma.SMURF1 facilitates estrogen receptor ɑ signaling in breast cancer cells.Delineating Crosstalk Mechanisms of the Ubiquitin Proteasome System That Regulate Apoptosis.Up-regulation of Smurf1 after spinal cord injury in adult rats.PKA/Smurf1 signaling-mediated stabilization of Nur77 is required for anticancer drug cisplatin-induced apoptosis.Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth.Crosstalk Between Mammalian Autophagy and the Ubiquitin-Proteasome System
P2860
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P2860
Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Smad ubiquitylation regulatory ...... tabilizing the E3 ligase MDM2.
@ast
Smad ubiquitylation regulatory ...... tabilizing the E3 ligase MDM2.
@en
Smad ubiquitylation regulatory factor 1/2
@nl
type
label
Smad ubiquitylation regulatory ...... tabilizing the E3 ligase MDM2.
@ast
Smad ubiquitylation regulatory ...... tabilizing the E3 ligase MDM2.
@en
Smad ubiquitylation regulatory factor 1/2
@nl
prefLabel
Smad ubiquitylation regulatory ...... tabilizing the E3 ligase MDM2.
@ast
Smad ubiquitylation regulatory ...... tabilizing the E3 ligase MDM2.
@en
Smad ubiquitylation regulatory factor 1/2
@nl
P2093
P2860
P356
P1476
Smad ubiquitylation regulatory ...... tabilizing the E3 ligase MDM2.
@en
P2093
Chunyan Tian
Guichun Xing
Lingqiang Zhang
Zhijie Chang
P2860
P304
22818-22830
P356
10.1074/JBC.M110.126920
P407
P577
2010-05-18T00:00:00Z