Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta.
about
Managing DNA polymerases: coordinating DNA replication, DNA repair, and DNA recombinationMolecular Dynamics Simulations and Structural Analysis to Decipher Functional Impact of a Twenty Residue Insert in the Ternary Complex of Mus musculus TdT IsoformThe Family X DNA Polymerase from Deinococcus radiodurans Adopts a Non-standard Extended ConformationOxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repairCharacterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJOver-expression of human DNA polymerase lambda in E. coli and characterization of the recombinant enzymeIdentification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repairStructure and mechanism of DNA polymerase βA quantitative model of human DNA base excision repair. I. Mechanistic insights.Enzymatic properties of rat DNA polymerase beta mutants obtained by randomized mutagenesisDNA structure and aspartate 276 influence nucleotide binding to human DNA polymerase beta. Implication for the identity of the rate-limiting conformational change.Structural comparison of DNA polymerase architecture suggests a nucleotide gateway to the polymerase active site.Base excision repair: a critical player in many gamesProbing the active site tightness of DNA polymerase in subangstrom increments.Highly organized but pliant active site of DNA polymerase beta: compensatory mechanisms in mutant enzymes revealed by dynamics simulations and energy analyses.Base excision repair is limited by different proteins in male germ cell nuclear extracts prepared from young and old mice.In silico studies of the African swine fever virus DNA polymerase X support an induced-fit mechanismReal-time surface plasmon resonance study of biomolecular interactions between polymerase and bulky mutagenic DNA lesions.Magnesium-induced assembly of a complete DNA polymerase catalytic complex.Loop II of DNA polymerase beta is important for polymerization activity and fidelity.Base excision repair and design of small molecule inhibitors of human DNA polymerase β.The DNA-polymerase-X family: controllers of DNA quality?Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairmentUnique 5'-P recognition and basis for dG:dGTP misincorporation of ASFV DNA polymerase X.Nucleotide binding interactions modulate dNTP selectivity and facilitate 8-oxo-dGTP incorporation by DNA polymerase lambda.Rules of engagement for base excision repair in chromatinReprint of "Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair".DNA polymerase β gap-filling translesion DNA synthesisDNA polymerase β variant Ile260Met generates global gene expression changes related to cellular transformation.Characterization of Mg2+ binding to the DNA repair protein apurinic/apyrimidic endonuclease 1 via solid-state 25Mg NMR spectroscopy.Production, Purification, and Characterization of ¹⁵N-Labeled DNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements.Identifying the features of purine dNTPs that allow accurate and efficient DNA replication by herpes simplex virus I DNA polymerase.How DNA polymerase X preferentially accommodates incoming dATP opposite 8-oxoguanine on the template.Targeting DNA polymerase ß for therapeutic intervention.Oxidized nucleotide insertion by pol β confounds ligation during base excision repair.Insights into the conformation of aminofluorene-deoxyguanine adduct in a DNA polymerase active site.Mouse models of DNA polymerases.Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repairKinetic effect of a downstream strand and its 5'-terminal moieties on single nucleotide gap-filling synthesis catalyzed by human DNA polymerase lambda.Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site.
P2860
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P2860
Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta.
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2000 nî lūn-bûn
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2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
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2000 թվականի օգոստոսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta.
@ast
Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta.
@en
Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta.
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type
label
Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta.
@ast
Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta.
@en
Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta.
@nl
prefLabel
Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta.
@ast
Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta.
@en
Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta.
@nl
P1433
P1476
Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta
@en
P2093
P304
P356
10.1016/S0921-8777(00)00029-X
P407
P577
2000-08-01T00:00:00Z