about
Nutlin-3a, an MDM2 antagonist and p53 activator, helps to preserve the replicative potential of cancer cells treated with a genotoxic dose of resveratrolRegulation of glucose metabolism by p53: emerging new roles for the tumor suppressorSestrins at the crossroad between stress and agingRibosomal proteins as unrevealed caretakers for cellular stress and genomic instabilityRapalogs in cancer prevention: anti-aging or anticancer?Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiencyNADPH oxidases: key modulators in aging and age-related cardiovascular diseases?Redox control of senescence and age-related diseaseP53-MDM2 Pathway: Evidences for A New Targeted Therapeutic Approach in B-Acute Lymphoblastic LeukemiaSenescence from G2 arrest, revisitedREDD1 protects osteoblast cells from gamma radiation-induced premature senescenceActivation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiformeSuppression of replicative senescence by rapamycin in rodent embryonic cellsRapamycin induces pluripotent genes associated with avoidance of replicative senescenceBig mice die young but large animals live longerElimination of proliferating cells unmasks the shift from senescence to quiescence caused by rapamycinDNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescenceContact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence programHyper-mitogenic drive coexists with mitotic incompetence in senescent cells.DNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cellsNew biomarkers probing depth of cell senescence assessed by laser scanning cytometry.Sustained activation of DNA damage response in irradiated apoptosis-resistant cells induces reversible senescence associated with mTOR downregulation and expression of stem cell markersp53 upregulation is a frequent response to deficiency of cell-essential genesFrom rapalogs to anti-aging formula.Avian reovirus p17 and σA act cooperatively to downregulate Akt by suppressing mTORC2 and CDK2/cyclin A2 and upregulating proteasome PSMB6.Age-related susceptibility to apoptosis in human retinal pigment epithelial cells is triggered by disruption of p53-Mdm2 association.Targeting Phosphatidylinositide3-Kinase/Akt pathway by BKM120 for radiosensitization in hepatocellular carcinomamTOR favors senescence over quiescence in p53-arrested cells.Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3.Attenuation of replication stress-induced premature cellular senescence to assess anti-aging modalities.Androgen receptor drives cellular senescence.Immortalization of MEF is characterized by the deregulation of specific miRNAs with potential tumor suppressor activityHormesis, cell death and aging.Interaction between the Cockayne syndrome B and p53 proteins: implications for agingHypoxia suppresses conversion from proliferative arrest to cellular senescence.Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?Berberine suppresses gero-conversion from cell cycle arrest to senescence.TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists.Selective anti-cancer agents as anti-aging drugsResistance to discodermolide, a microtubule-stabilizing agent and senescence inducer, is 4E-BP1-dependent.
P2860
Q24595171-ADF8B31C-8382-4440-9F5B-FF48C3474DB7Q24631421-EACBCFF3-56AF-47BB-ADF5-46E3C30B1E30Q24633564-93F0BC7C-7D55-4E4B-A952-393CEE85DBB9Q26829490-5B714D40-144E-4BCC-A5ED-398567ED418EQ26866151-AEEC73DF-6AD5-417B-AC2E-9FCBC555D0CEQ27315143-89631A1A-468A-47F8-B237-0B5360EF4195Q28072348-6D896851-D104-4680-9848-23D9EB881A68Q28074230-4473815D-01EA-443E-AF4A-542976952AF8Q28078609-A9C668F5-AF06-43DC-BC7A-CBFA9D58838FQ28088672-0758CAD9-6425-4DEC-8E42-6BF5B90B3D36Q28384621-86725BFB-6BF1-4A33-9EB9-7975A0FD74E1Q28477660-9EF14A6B-61E6-4E0D-8C94-49933AAD80C0Q28571864-480D3A6C-DE27-4CDC-9E3E-7C1FEEE1D3C2Q28572137-A9021942-B702-4913-BD56-2DB271090961Q28704146-3DEFDBF8-5A35-416B-9314-E2C0DFE7D90AQ28744036-8744CA00-8844-4567-A574-CF6981BCCBDDQ28972513-CD6EEE6B-CCE1-4C55-ACAA-4EA6259B7E12Q28972583-A5B4A801-191B-4C52-A0A4-D314087003B4Q30533934-37887424-DE02-45B2-9F77-40390A40AA62Q30537160-A10AB471-ACEC-40B7-A5AD-87796D78F4D9Q33715537-99F1C4ED-5012-4E76-A80C-FA92F904BAC5Q33728894-8F3F8C0C-0EC0-4AC8-BD54-99D46E67C56FQ33786749-53AA1F00-6631-4113-A24A-ECB7E46ED6A1Q33829205-3C5FCA39-CC04-44AF-9D5D-E8EE92CD1FE2Q33899583-99F2FD46-E988-45F4-843A-33A7F67B983DQ33961165-731AE50C-6924-416C-ACEC-4720E1BD8DF8Q33977001-6662345B-C661-4F58-AF50-E16BB6CEBCACQ34056457-06A6BFB7-8954-428C-BECB-878BA28FD773Q34100963-7937D67F-65D8-451C-8989-9B60F1638108Q34145091-C667510A-6E5F-4599-85F8-2F9FF5C2EFCBQ34189267-E5982E6F-A812-4795-B0E2-5E649DC8B436Q34201222-F77BDBCE-72E2-46A5-9EA1-FA266E5FE0A9Q34217654-FF8950E3-2BBE-405B-8D1C-D135EB0F800AQ34258129-CED9495E-2FDD-4D6B-8810-E5C63A58B8D2Q34291377-BC781910-5A59-47FC-B0B3-92AD34484EAAQ34322386-187CBE0E-15EB-4014-8856-B9CCCF537A07Q34366519-8DE4336E-4B80-42D8-9649-01DB6E24A73EQ34391710-6E817F6F-EA54-4E9D-A186-24F2E0540EF8Q34392470-DAE17B41-D97B-4FF4-8D52-6FE11073AB8FQ34471836-0B158D35-07D7-4767-A6F5-65A952F96B87
P2860
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Paradoxical suppression of cellular senescence by p53
@ast
Paradoxical suppression of cellular senescence by p53
@en
Paradoxical suppression of cellular senescence by p53
@nl
type
label
Paradoxical suppression of cellular senescence by p53
@ast
Paradoxical suppression of cellular senescence by p53
@en
Paradoxical suppression of cellular senescence by p53
@nl
prefLabel
Paradoxical suppression of cellular senescence by p53
@ast
Paradoxical suppression of cellular senescence by p53
@en
Paradoxical suppression of cellular senescence by p53
@nl
P2093
P2860
P356
P1476
Paradoxical suppression of cellular senescence by p53
@en
P2093
Andrei V Gudkov
Lioubov G Korotchkina
Zoya N Demidenko
P2860
P304
P356
10.1073/PNAS.1002298107
P407
P577
2010-05-10T00:00:00Z