Biosynthetic engineering of polyene macrolides towards generation of improved antifungal and antiparasitic agents.
about
Structure of Cytochrome P450 PimD Suggests Epoxidation of the Polyene Macrolide Pimaricin Occurs via a Hydroperoxoferric IntermediateA labile point in mutant amphotericin polyketide synthasesLAL regulators SCO0877 and SCO7173 as pleiotropic modulators of phosphate starvation response and actinorhodin biosynthesis in Streptomyces coelicolorAntifungal activity of rimocidin and a new rimocidin derivative BU16 produced by Streptomyces mauvecolor BU16 and their effects on pepper anthracnose.Genomic basis for natural product biosynthetic diversity in the actinomycetesStructure-antifungal activity relationships of polyene antibiotics of the amphotericin B group.Novel Nystatin A₁ derivatives exhibiting low host cell toxicity and antifungal activity in an in vitro model of oral candidosis.New Rimocidin/CE-108 Derivatives Obtained by a Crotonyl-CoA Carboxylase/Reductase Gene Disruption in Streptomyces diastaticus var. 108: Substrates for the Polyene Carboxamide Synthase PcsA.Tailoring the P450 monooxygenase gene for FR-008/candicidin biosynthesis.The regulation of the secondary metabolism of Streptomyces: new links and experimental advances.Biosynthesis and pathway engineering of antifungal polyene macrolides in actinomycetes.Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation.New nystatin-related antifungal polyene macrolides with altered polyol region generated via biosynthetic engineering of Streptomyces noursei.Polyene macrolide biosynthesis in streptomycetes and related bacteria: recent advances from genome sequencing and experimental studies.Betamethasone augments the antifungal effect of menadione--towards a novel anti-Candida albicans combination therapy.New polyene macrolide family produced by submerged culture of Streptomyces durmitorensis.Two Master Switch Regulators Trigger A40926 Biosynthesis in Nonomuraea sp. Strain ATCC 39727.PimT, an amino acid exporter controls polyene production via secretion of the quorum sensing pimaricin-inducer PI-factor in Streptomyces natalensis.Control of human and plant fungal pathogens using pentaene macrolide 32, 33-didehydroroflamycoin.Hierarchical control on polyene macrolide biosynthesis: PimR modulates pimaricin production via the PAS-LuxR transcriptional activator PimM.Molecular control of polyene macrolide biosynthesis: direct binding of the regulator PimM to eight promoters of pimaricin genes and identification of binding boxes.A comparison of key aspects of gene regulation in Streptomyces coelicolor and Escherichia coli using nucleotide-resolution transcription maps produced in parallel by global and differential RNA sequencing.Versatility of enzymes catalyzing late steps in polyene 67-121C biosynthesis.Biosynthesis regulation of natamycin production from Streptomyces natalensis HDMNTE-01 enhanced by response surface methodology.New insights into polyene macrolide biosynthesis in Couchioplanes caeruleus.
P2860
Q27664192-733A5481-883F-4C88-B9F2-465BF2D63DB7Q28304029-195FE531-C10E-4220-87AD-E139E7B4602DQ34170994-9058B419-7599-4392-96EF-18425F8FD02AQ34510722-24E37D07-C7E2-4C8F-807C-B6D54983A241Q34711979-EFA35F96-010B-4226-BC9F-B3B3113AFA48Q34743567-66397B43-85C6-446D-9FEC-E3925592F835Q35187151-F3E49436-AFC6-421F-9E98-C45F6292118AQ35748870-38B76148-9BFC-4CFD-B1FA-C9DF54DCC040Q37127720-C51C14D5-5649-4BBE-88F3-1C77A2EECB53Q37879562-ACF31BA4-8D1C-40BF-A29F-B37CF681C9ABQ38091646-C834A389-D0D6-4E04-93F2-F39C95E90B56Q38618926-06FCCE6F-6508-4790-96F9-DDDB327C0C3EQ38628520-8C10E3F4-2013-4AC0-8F38-7BD219D7624BQ38792678-51A3B720-C731-40C0-B310-B57BA0CA128CQ39036231-98FACD02-E687-4CFC-B9DD-D1A508D4056EQ39474309-591E348D-AEA2-47C4-8E29-B0EDFC80DB9AQ41221156-97BE56B6-339D-4C89-ADBE-5E35FA57D51EQ41346634-4214569F-A80A-41C2-8D4D-02D48ECC97DEQ41382937-43804A19-1F33-4FCF-95ED-E8E48712ACFEQ41973362-5CCA9C71-6307-4F4C-A055-D914B5DF8AF6Q42042567-BE6A7E17-FFD5-4840-8B4F-966A9D4086DFQ42652554-DB8F24F4-A700-45DC-B8A4-7379E91A79E4Q45065940-C2FA20D9-D6D9-44EB-B65C-6764638ED3D6Q47785258-DAB28670-EBCA-4F28-82D1-9B906F626A82Q51069123-457A4C8F-7668-47AE-9B03-60B9544D4FC9
P2860
Biosynthetic engineering of polyene macrolides towards generation of improved antifungal and antiparasitic agents.
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Biosynthetic engineering of po ...... ngal and antiparasitic agents.
@ast
Biosynthetic engineering of po ...... ngal and antiparasitic agents.
@en
Biosynthetic engineering of po ...... ngal and antiparasitic agents.
@nl
type
label
Biosynthetic engineering of po ...... ngal and antiparasitic agents.
@ast
Biosynthetic engineering of po ...... ngal and antiparasitic agents.
@en
Biosynthetic engineering of po ...... ngal and antiparasitic agents.
@nl
prefLabel
Biosynthetic engineering of po ...... ngal and antiparasitic agents.
@ast
Biosynthetic engineering of po ...... ngal and antiparasitic agents.
@en
Biosynthetic engineering of po ...... ngal and antiparasitic agents.
@nl
P1476
Biosynthetic engineering of po ...... ungal and antiparasitic agents
@en
P2093
Francisco Malpartida
Patrick Caffrey
P304
P356
10.2174/156802608784221479
P577
2008-01-01T00:00:00Z