about
The biosynthetic gene cluster for the polyketide immunosuppressant rapamycinBiosynthetic engineering of polyene macrolides towards generation of improved antifungal and antiparasitic agents.LAL regulators SCO0877 and SCO7173 as pleiotropic modulators of phosphate starvation response and actinorhodin biosynthesis in Streptomyces coelicolorDraft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the clinically important immunosuppressant tacrolimus (FK506).Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivativesPolyene antibiotic biosynthesis gene clusters.Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation.Evidence for a double-helical structure for modular polyketide synthases.Hierarchical control on polyene macrolide biosynthesis: PimR modulates pimaricin production via the PAS-LuxR transcriptional activator PimM.Molecular control of polyene macrolide biosynthesis: direct binding of the regulator PimM to eight promoters of pimaricin genes and identification of binding boxes.Characterization of the ask-asd operon in aminoethoxyvinylglycine-producing Streptomyces sp. NRRL 5331.Engineered biosynthesis of novel polyenes: a pimaricin derivative produced by targeted gene disruption in Streptomyces natalensis.Functional conservation of PAS-LuxR transcriptional regulators in polyene macrolide biosynthesis.Domain structure characterization of the multifunctional alpha-aminoadipate reductase from Penicillium chrysogenum by limited proteolysis. Activation of alpha-aminoadipate does not require the peptidyl carrier protein box or the reduction domain.Genome-wide analysis of the regulation of pimaricin production in Streptomyces natalensis by reactive oxygen species.Role of homoserine and threonine pathway intermediates as precursors for the biosynthesis of aminoethoxyvinylglycine in Streptomyces sp. NRRL 5331.PI factor, a novel type quorum-sensing inducer elicits pimaricin production in Streptomyces natalensis.Enzymology of the polyenes pimaricin and candicidin biosynthesis.The biosynthetic gene cluster for the 26-membered ring polyene macrolide pimaricin. A new polyketide synthase organization encoded by two subclusters separated by functionalization genes.PimM, a PAS domain positive regulator of pimaricin biosynthesis in Streptomyces natalensis.The two-component phoR-phoP system of Streptomyces natalensis: Inactivation or deletion of phoP reduces the negative phosphate regulation of pimaricin biosynthesis.Promoter Engineering Reveals the Importance of Heptameric Direct Repeats for DNA Binding by Streptomyces Antibiotic Regulatory Protein-Large ATP-Binding Regulator of the LuxR Family (SARP-LAL) Regulators in Streptomyces natalensis.Generating novel polyene antifungal drugs.PAS-LuxR transcriptional control of filipin biosynthesis in S. avermitilis.An efficient gene transfer system for the pimaricin producer Streptomyces natalensis.Cholesterol Oxidases Act as Signaling Proteins for the Biosynthesis of the Polyene Macrolide PimaricinPhosphate effect on filipin production and morphological differentiation in Streptomyces filipinensis and the role of the PhoP transcription factorDivergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthasesActivation of Secondary Metabolite Gene Clusters in by the PimM Regulator ofStereospecific acyl transfers on the erythromycin-producing polyketide synthaseGlycerol, ethylene glycol and propanediol elicit pimaricin biosynthesis in the PI-factor-defective strain Streptomyces natalensis npi287 and increase polyene production in several wild-type actinomycetesPathway-specific regulation revisited: cross-regulation of multiple disparate gene clusters by PAS-LuxR transcriptional regulators
P50
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P50
description
researcher
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wetenschapper
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հետազոտող
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Jesús F Aparicio
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Jesús F Aparicio
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Jesús F Aparicio
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Jesús F Aparicio
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Jesús F Aparicio
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Jesús F Aparicio
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Jesús F Aparicio
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Jesús F Aparicio
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Jesús F Aparicio
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Jesús F Aparicio
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Jesús F Aparicio
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Jesús F Aparicio
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P106
P31
P496
0000-0003-4242-4701