The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.
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The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective mannerDiscovery of Potent and Selective Covalent Inhibitors of JNKNovel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973)A single-cell and feeder-free culture system for monkey embryonic stem cellsTAMH: A Useful In Vitro Model for Assessing Hepatotoxic MechanismsA novel loss-of-function mutation in Npr2 clarifies primary role in female reproduction and reveals a potential therapy for acromesomelic dysplasia, Maroteaux typeA metabolic perturbation by U0126 identifies a role for glutamine in resveratrol-induced cell death.Identification of protein kinase inhibitors with a selective negative effect on the viability of Epstein-Barr virus infected B cell linesMAPK pathway inhibition induces MET and GAB1 levels, priming BRAF mutant melanoma for rescue by hepatocyte growth factor.Chemical reprogramming of Caenorhabditis elegans germ cell fateFrom basic research to clinical development of MEK1/2 inhibitors for cancer therapy.Small-molecule inhibitors of the ERK signaling pathway: Towards novel anticancer therapeutics.MEK and the inhibitors: from bench to bedside.MEK inhibitor PD0325901 significantly reduces the growth of papillary thyroid carcinoma cells in vitro and in vivoSmall molecule screening identifies targetable zebrafish pigmentation pathways.Use of kinase inhibitors to correct ΔF508-CFTR function.Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape.MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutationCell plasticity in Caenorhabditis elegans: from induced to natural cell reprogramming.SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1.The enhanced in vivo activity of the combination of a MEK and a PI3K inhibitor correlates with [18F]-FLT PET in human colorectal cancer xenograft tumour-bearing mice.Inhibition of transforming growth factor β (TGF-β) signaling can substitute for Oct4 protein in reprogramming and maintain pluripotencyThe BRAF kinase domain promotes the development of gliomas in vivo.Dual-specificity phosphatase 6 regulates CD4+ T-cell functions and restrains spontaneous colitis in IL-10-deficient mice.Effect of the transient pharmacological inhibition of Mapk3/1 pathway on ovulation in mice.PIK3CA mutation uncouples tumor growth and cyclin D1 regulation from MEK/ERK and mutant KRAS signalingFibroblast growth factor 23 regulates renal 1,25-dihydroxyvitamin D and phosphate metabolism via the MAP kinase signaling pathway in Hyp miceSynergy between inhibitors of androgen receptor and MEK has therapeutic implications in estrogen receptor-negative breast cancer.Mixed-effects model of epithelial-mesenchymal transition reveals rewiring of signaling networksA MEK inhibitor abrogates myeloproliferative disease in Kras mutant mice.Genomic complexity and AKT dependence in serous ovarian cancer.4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors.Epidermal growth factor receptor inhibition in lung cancer: the evolving role of individualized therapyDevelopment of a High-Throughput Gene Expression Screen for Modulators of RAS-MAPK Signaling in a Mutant RAS Cellular Context.The use of novel selectivity metrics in kinase research.Activating BRAF and PIK3CA mutations cooperate to promote anaplastic thyroid carcinogenesis.MEK1/2 Inhibitors: Molecular Activity and Resistance Mechanisms.p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model.Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice.BRAFV600E induces ABCB1/P-glycoprotein expression and drug resistance in B-cells via AP-1 activation.
P2860
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P2860
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.
@ast
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.
@en
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.
@nl
type
label
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.
@ast
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.
@en
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.
@nl
prefLabel
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.
@ast
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.
@en
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.
@nl
P2093
P1476
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.
@en
P2093
Alan R Saltiel
Alexander J Bridges
Amy M Delaney
Annette M Doherty
Cathlin M Flamme
Dan Marston
David T Dudley
Haile Tecle
James H Fergus
Joseph S Warmus
P304
P356
10.1016/J.BMCL.2008.10.054
P407
P577
2008-10-15T00:00:00Z