Telomerase reverse transcriptase delays aging in cancer-resistant mice.
about
The secreted protein S100A7 (psoriasin) is induced by telomere dysfunction in human keratinocytes independently of a DNA damage response and cell cycle regulatorsFeedback between p21 and reactive oxygen production is necessary for cell senescenceTelomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancerSingle-gene mutations and healthy ageing in mammalsManipulation of DNA Repair Proficiency in Mouse Models of Colorectal CancerTherapeutic Targeting of TelomeraseTelomeres and telomerase as therapeutic targets to prevent and treat age-related diseasesWhen stem cells grow old: phenotypes and mechanisms of stem cell agingTelomeres-structure, function, and regulationMolecular regulation of telomerase activity in agingAxis of ageing: telomeres, p53 and mitochondriaProgramming and Reprogramming Cellular Age in the Era of Induced PluripotencyThe germline/soma dichotomy: implications for aging and degenerative diseaseDifferential Protein Distribution between the Nucleus and Mitochondria: Implications in AgingThe hallmarks of agingLinking functional decline of telomeres, mitochondria and stem cells during ageingThe role of telomeres and telomerase in stem cell agingImpact of genomic damage and ageing on stem cell functionGrowth conditions that increase or decrease lifespan in Saccharomyces cerevisiae lead to corresponding decreases or increases in rates of interstitial deletions and non-reciprocal translocationsSingle-cell telomere-length quantification couples telomere length to meristem activity and stem cell development in ArabidopsisA p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres.Comparative proteomics analysis of cardiac muscle samples from pufferfish Takifugu rubripes exposed to excessive fluoride: initial molecular response to fluorosis.The protein subunit of telomerase displays patterns of dynamic evolution and conservation across different metazoan taxa.It's all about balance: p53 and agingTelomeres: protecting chromosomes against genome instabilityChronic inflammation induces telomere dysfunction and accelerates ageing in mice.Epigenetics: Linking Nutrition to Molecular Mechanisms in Aging.Pif1 regulates telomere length by preferentially removing telomerase from long telomere endsZinc finger protein 637 protects cells against oxidative stress-induced premature senescence by mTERT-mediated telomerase activity and telomere maintenance.Four faces of cellular senescence.Stem cell aging: mechanisms, regulators and therapeutic opportunities.The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidenceProgeroid syndromes: models for stem cell aging?Dynamic energy budget approaches for modelling organismal ageing.TRF1 is a stem cell marker and is essential for the generation of induced pluripotent stem cells.Mammalian models of extended healthy lifespan.Telomeres in cancer and ageing.SIRT1 contributes to telomere maintenance and augments global homologous recombination.Haematopoietic stem and progenitor cells in rheumatoid arthritis
P2860
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P2860
Telomerase reverse transcriptase delays aging in cancer-resistant mice.
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Telomerase reverse transcriptase delays aging in cancer-resistant mice.
@ast
Telomerase reverse transcriptase delays aging in cancer-resistant mice.
@en
Telomerase reverse transcriptase delays aging in cancer-resistant mice.
@nl
type
label
Telomerase reverse transcriptase delays aging in cancer-resistant mice.
@ast
Telomerase reverse transcriptase delays aging in cancer-resistant mice.
@en
Telomerase reverse transcriptase delays aging in cancer-resistant mice.
@nl
prefLabel
Telomerase reverse transcriptase delays aging in cancer-resistant mice.
@ast
Telomerase reverse transcriptase delays aging in cancer-resistant mice.
@en
Telomerase reverse transcriptase delays aging in cancer-resistant mice.
@nl
P2093
P50
P1433
P1476
Telomerase reverse transcriptase delays aging in cancer-resistant mice.
@en
P2093
Ander Matheu
Antonia Tomás-Loba
Consuelo Borrás
Juana M Flores
María L Cayuela
Pablo J Fernández-Marcos
Peter Klatt
P304
P356
10.1016/J.CELL.2008.09.034
P407
P577
2008-11-01T00:00:00Z